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BRPI0516177A - oligorribonucleotìdios e métodos para uso dos mesmos para o tratamento da alopécia, insuficiência renal aguda e outras doenças - Google Patents

oligorribonucleotìdios e métodos para uso dos mesmos para o tratamento da alopécia, insuficiência renal aguda e outras doenças

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Publication number
BRPI0516177A
BRPI0516177A BRPI0516177-0A BRPI0516177A BRPI0516177A BR PI0516177 A BRPI0516177 A BR PI0516177A BR PI0516177 A BRPI0516177 A BR PI0516177A BR PI0516177 A BRPI0516177 A BR PI0516177A
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BR
Brazil
Prior art keywords
diseases
alopecia
patient
treatment
methods
Prior art date
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BRPI0516177-0A
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English (en)
Inventor
Elena Feinstein
Daniel Zurr
Shai Ehrlich
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Quark Biotech Inc
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Publication date
Application filed by Quark Biotech Inc filed Critical Quark Biotech Inc
Publication of BRPI0516177A publication Critical patent/BRPI0516177A/pt
Publication of BRPI0516177B1 publication Critical patent/BRPI0516177B1/pt
Publication of BRPI0516177B8 publication Critical patent/BRPI0516177B8/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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Abstract

OLIGORRIBONUCLEOTìDIOS E MéTODOS PARA USO DOS MESMOS PARA O TRATAMENTO DA ALOPéCIA, INSUFICIêNCIA RENAL AGUDA E OUTRAS DOENçAS. A presente invenção se relaciona a um composto de dupla fita, preferivelmente um oligorribonucleotídio, que infra-regula a expressão de um gene p53 humano. A presente invenção também se relaciona com uma composição farmacêutica compreendendo um composto, ou um vetor capaz de expressar o composto de oligorribonucleotídio, e um transportador farmacêuticamente aceitável. A presente invenção também contempla um método para tratar um paciente que esteja sofrendo de alopécia ou insuficiência renal aguda ou de outras doenças compreendendo a administração ao paciente de uma composição farmacêutica em uma dose terapeuticamente eficaz para tratar desse modo o paciente. A alopécia pode ser induzida por quimioterapia ou radioterapia, e o paciente pode estar sofrendo de câncer, e particularmente de câncer de mama.
BRPI0516177A 2004-09-28 2005-09-27 oligorribonucleotídeos, uso dos mesmos, uso de um composto sirna eficaz para inibir 0 p53 humano e composição farmacêutica que os contém, bem como método para diminuição da expressão do gene p53 BRPI0516177B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61399104P 2004-09-28 2004-09-28
US65819605P 2005-03-02 2005-03-02
US70302005P 2005-07-26 2005-07-26
PCT/IL2005/001035 WO2006035434A2 (en) 2004-09-28 2005-09-27 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases

Publications (3)

Publication Number Publication Date
BRPI0516177A true BRPI0516177A (pt) 2008-08-26
BRPI0516177B1 BRPI0516177B1 (pt) 2019-01-08
BRPI0516177B8 BRPI0516177B8 (pt) 2021-05-25

Family

ID=36119277

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516177A BRPI0516177B8 (pt) 2004-09-28 2005-09-27 oligorribonucleotídeos, uso dos mesmos, uso de um composto sirna eficaz para inibir 0 p53 humano e composição farmacêutica que os contém, bem como método para diminuição da expressão do gene p53

Country Status (19)

Country Link
US (5) US8765699B2 (pt)
EP (1) EP1799269B1 (pt)
JP (3) JP4991547B2 (pt)
KR (2) KR101409241B1 (pt)
CN (1) CN102643818B (pt)
AU (1) AU2005288522B2 (pt)
BR (1) BRPI0516177B8 (pt)
CA (1) CA2580126C (pt)
DK (1) DK1799269T3 (pt)
ES (1) ES2594083T3 (pt)
HU (1) HUE030844T2 (pt)
LT (1) LT1799269T (pt)
MX (2) MX2007003795A (pt)
NZ (1) NZ553987A (pt)
PL (1) PL1799269T3 (pt)
PT (1) PT1799269T (pt)
RU (1) RU2584609C2 (pt)
SG (1) SG161307A1 (pt)
WO (1) WO2006035434A2 (pt)

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