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BR112022003282A2 - Glicovariantes de igm - Google Patents

Glicovariantes de igm

Info

Publication number
BR112022003282A2
BR112022003282A2 BR112022003282A BR112022003282A BR112022003282A2 BR 112022003282 A2 BR112022003282 A2 BR 112022003282A2 BR 112022003282 A BR112022003282 A BR 112022003282A BR 112022003282 A BR112022003282 A BR 112022003282A BR 112022003282 A2 BR112022003282 A2 BR 112022003282A2
Authority
BR
Brazil
Prior art keywords
igm
heavy chain
variant
derived
glycovariants
Prior art date
Application number
BR112022003282A
Other languages
English (en)
Inventor
Bruce Keyt
Dean Ng
Ramesh Baliga
Original Assignee
Igm Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igm Biosciences Inc filed Critical Igm Biosciences Inc
Publication of BR112022003282A2 publication Critical patent/BR112022003282A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

glicovariantes de igm referência cruzada a pedidos relacionados. esta divulgação fornece uma molécula de ligação derivada de igm isolada, por exemplo, um anticorpo igm, anticorpo semelhante a igm ou outra molécula de ligação derivada de igm, incluindo pelo menos uma cadeia pesada derivada da igm variante, onde a pelo menos uma cadeia pesada derivada da igm variante inclui uma região constante de cadeia pesada da igm variante associada a um domínio de ligação que se liga especificamente a um alvo, onde pelo menos um motivo de gli-cosilação (n)-ligado de asparagina da região constante de cadeia pesada da igm variante é mutado para evitar a glicosilação nesse motivo, e/ou pelo menos um mo-tivo de glicosilação n-ligado é introduzido na cadeia pesada da igm variante.
BR112022003282A 2019-08-23 2020-08-21 Glicovariantes de igm BR112022003282A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962891263P 2019-08-23 2019-08-23
PCT/US2020/047495 WO2021041250A1 (en) 2019-08-23 2020-08-21 Igm glycovariants

Publications (1)

Publication Number Publication Date
BR112022003282A2 true BR112022003282A2 (pt) 2022-05-24

Family

ID=74684266

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022003282A BR112022003282A2 (pt) 2019-08-23 2020-08-21 Glicovariantes de igm

Country Status (11)

Country Link
US (1) US20220306760A1 (pt)
EP (1) EP4017533A4 (pt)
JP (1) JP2022545682A (pt)
KR (1) KR20220050166A (pt)
CN (1) CN114269380A (pt)
AU (1) AU2020337333A1 (pt)
BR (1) BR112022003282A2 (pt)
CA (1) CA3149350A1 (pt)
IL (1) IL290253A (pt)
MX (1) MX2022002239A (pt)
WO (1) WO2021041250A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015240595B2 (en) 2014-04-03 2020-02-27 Igm Biosciences, Inc. Modified J-chain
US10689449B2 (en) 2015-01-20 2020-06-23 Igm Biosciences, Inc. Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof
AU2016238246B2 (en) 2015-03-25 2021-05-13 Igm Biosciences, Inc. Multi-valent hepatitis B virus antigen binding molecules and uses thereof
WO2017059387A1 (en) 2015-09-30 2017-04-06 Igm Biosciences, Inc. Binding molecules with modified j-chain
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
IL311039A (en) * 2021-09-17 2024-04-01 Adimab Llc Anti-cd3 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2125894T (lt) * 2007-03-22 2019-03-25 Biogen Ma Inc. Prisijungiantys baltymai, įskaitant antikūnus, antikūno dariniai ir antikūno fragmentai, kurie specifiškai suriša cd154, ir jų panaudojimas
WO2011056997A1 (en) * 2009-11-04 2011-05-12 Fabrus Llc Methods for affinity maturation-based antibody optimization
AU2015240595B2 (en) * 2014-04-03 2020-02-27 Igm Biosciences, Inc. Modified J-chain
AU2016329197B2 (en) * 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
JP7138046B2 (ja) * 2015-12-18 2022-09-15 バイオジェン・エムエイ・インコーポレイテッド 二特異性抗体基幹
EP3571222A4 (en) * 2017-01-19 2021-06-16 Cedars-Sinai Medical Center METHOD BASED ON HIGHLY MULTIPLEX AND MASS SPECTROMETRY FOR MEASURING HUMAN 72 PROTEINS
KR20190138636A (ko) * 2017-03-22 2019-12-13 제넨테크, 인크. 안구 장애의 치료를 위한 최적화된 항체 조성물
WO2019106578A2 (en) * 2017-12-01 2019-06-06 Novartis Ag Polyomavirus neutralizing antibodies

Also Published As

Publication number Publication date
WO2021041250A1 (en) 2021-03-04
CN114269380A (zh) 2022-04-01
JP2022545682A (ja) 2022-10-28
MX2022002239A (es) 2022-03-22
CA3149350A1 (en) 2021-03-04
EP4017533A4 (en) 2024-03-27
AU2020337333A1 (en) 2022-03-03
EP4017533A1 (en) 2022-06-29
US20220306760A1 (en) 2022-09-29
IL290253A (en) 2022-04-01
KR20220050166A (ko) 2022-04-22

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