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BR112022005826A2 - Compostos de pirido[3,2-d]pirimidina como imunomoduladores - Google Patents

Compostos de pirido[3,2-d]pirimidina como imunomoduladores

Info

Publication number
BR112022005826A2
BR112022005826A2 BR112022005826A BR112022005826A BR112022005826A2 BR 112022005826 A2 BR112022005826 A2 BR 112022005826A2 BR 112022005826 A BR112022005826 A BR 112022005826A BR 112022005826 A BR112022005826 A BR 112022005826A BR 112022005826 A2 BR112022005826 A2 BR 112022005826A2
Authority
BR
Brazil
Prior art keywords
immunomodulators
pyrido
pyrimidine compounds
compounds
protein
Prior art date
Application number
BR112022005826A
Other languages
English (en)
Inventor
Jingwei Li
Liangxing Wu
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BR112022005826A2 publication Critical patent/BR112022005826A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

compostos de pirido[3,2-d]pirimidina como imunomoduladores. a presente divulgação refere-se a compostos de fórmula (i) que modulam a interação proteína/proteína de pd-1/pd-l1, composições e métodos de tratamento de várias doenças, incluindo doenças infecciosas e câncer.
BR112022005826A 2019-09-30 2020-09-29 Compostos de pirido[3,2-d]pirimidina como imunomoduladores BR112022005826A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (1)

Publication Number Publication Date
BR112022005826A2 true BR112022005826A2 (pt) 2022-06-21

Family

ID=72886166

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005826A BR112022005826A2 (pt) 2019-09-30 2020-09-29 Compostos de pirido[3,2-d]pirimidina como imunomoduladores

Country Status (19)

Country Link
US (2) US11401279B2 (pt)
EP (1) EP4037773A1 (pt)
JP (1) JP7559059B2 (pt)
KR (1) KR20220075382A (pt)
CN (1) CN115175734B (pt)
AR (1) AR120109A1 (pt)
AU (1) AU2020357514A1 (pt)
BR (1) BR112022005826A2 (pt)
CA (1) CA3155852A1 (pt)
CL (1) CL2022000787A1 (pt)
CO (1) CO2022005378A2 (pt)
CR (1) CR20220190A (pt)
EC (1) ECSP22034236A (pt)
IL (1) IL291471B2 (pt)
MX (1) MX2022003578A (pt)
PE (1) PE20221038A1 (pt)
PH (1) PH12022550754A1 (pt)
TW (1) TWI879811B (pt)
WO (1) WO2021067217A1 (pt)

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US20170342060A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
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US20180057486A1 (en) 2016-08-29 2018-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
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BR112022005826A2 (pt) * 2019-09-30 2022-06-21 Incyte Corp Compostos de pirido[3,2-d]pirimidina como imunomoduladores
US11866451B2 (en) 2019-11-11 2024-01-09 Incyte Corporation Salts and crystalline forms of a PD-1/PD-L1 inhibitor
US20230234970A1 (en) * 2020-06-17 2023-07-27 Abbisko Therapeutics Co., Ltd. Immunosuppressant, and preparation method therefor and use thereof
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