BR112018068676A2 - derivados de indol substituídos como inibidores da replicação viral do dengue - Google Patents
derivados de indol substituídos como inibidores da replicação viral do dengueInfo
- Publication number
- BR112018068676A2 BR112018068676A2 BR112018068676A BR112018068676A BR112018068676A2 BR 112018068676 A2 BR112018068676 A2 BR 112018068676A2 BR 112018068676 A BR112018068676 A BR 112018068676A BR 112018068676 A BR112018068676 A BR 112018068676A BR 112018068676 A2 BR112018068676 A2 BR 112018068676A2
- Authority
- BR
- Brazil
- Prior art keywords
- indole derivatives
- substituted indole
- compounds
- viral replication
- dengue viral
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 4
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 229940123627 Viral replication inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
a presente invenção refere-se a derivados de indol substituídos, métodos para prevenir ou tratar infecções virais do dengue por uso dos referidos compostos e se refere também aos referidos compostos para uso como um medicamento, mais preferencialmente, para uso como um medicamento para tratar ou prevenir infecções virais do dengue. a presente invenção refere-se, além disso, a composições farmacêuticas ou preparações de combinação dos compostos, às composições ou preparações para uso como um medicamento, mais preferencialmente, para a prevenção ou tratamento de infecções virais do dengue. a invenção se refere também a processos para preparação dos compostos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163312 | 2016-03-31 | ||
| PCT/EP2017/057660 WO2017167950A1 (en) | 2016-03-31 | 2017-03-31 | Substituted indole derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018068676A2 true BR112018068676A2 (pt) | 2019-01-15 |
Family
ID=55650292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018068676A BR112018068676A2 (pt) | 2016-03-31 | 2017-03-31 | derivados de indol substituídos como inibidores da replicação viral do dengue |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10646469B2 (pt) |
| EP (1) | EP3436435B1 (pt) |
| JP (1) | JP6888021B2 (pt) |
| KR (1) | KR102359743B1 (pt) |
| CN (1) | CN108884033B (pt) |
| AU (1) | AU2017242893A1 (pt) |
| BR (1) | BR112018068676A2 (pt) |
| CA (1) | CA3013405A1 (pt) |
| CL (1) | CL2018002729A1 (pt) |
| CO (1) | CO2018009559A2 (pt) |
| CR (1) | CR20180495A (pt) |
| DK (1) | DK3436435T3 (pt) |
| EA (1) | EA201892214A1 (pt) |
| EC (1) | ECSP18073245A (pt) |
| ES (1) | ES2882488T3 (pt) |
| HK (1) | HK1258142A1 (pt) |
| HR (1) | HRP20210847T1 (pt) |
| HU (1) | HUE054936T2 (pt) |
| IL (1) | IL261944A (pt) |
| LT (1) | LT3436435T (pt) |
| MX (1) | MX2018011784A (pt) |
| PH (1) | PH12018502015A1 (pt) |
| SG (1) | SG11201808138YA (pt) |
| SI (1) | SI3436435T1 (pt) |
| WO (1) | WO2017167950A1 (pt) |
| ZA (1) | ZA201806473B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG11201808270PA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112018068676A2 (pt) | 2016-03-31 | 2019-01-15 | Janssen Pharmaceuticals Inc | derivados de indol substituídos como inibidores da replicação viral do dengue |
| MA44502A (fr) * | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| TWI771420B (zh) | 2017-05-22 | 2022-07-21 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之經取代之吲哚啉衍生物（一） |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| WO2024178504A1 (en) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| AU2006204917A1 (en) | 2005-01-14 | 2006-07-20 | Smithkline Beecham Corporation | Indole derivatives for treating viral infections |
| JP2008530124A (ja) | 2005-02-09 | 2008-08-07 | ミジェニックス インコーポレイテッド | フラビウイルス感染症を処置または予防するための組成物および方法 |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| ES2543105T3 (es) | 2010-01-15 | 2015-08-14 | Gilead Sciences, Inc. | Inhibidores de virus flaviviridae |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| AU2014338947B2 (en) | 2013-10-23 | 2018-02-22 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2015116885A1 (en) | 2014-01-31 | 2015-08-06 | Bristol-Myers Squibb Company | Macrocycles with aromatic p2' groups as factor xia inhibitors |
| NO2721243T3 (pt) | 2014-10-01 | 2018-10-20 | ||
| EP3201176B1 (en) | 2014-10-01 | 2018-12-12 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| RS58394B1 (sr) | 2014-10-01 | 2019-04-30 | Janssen Pharmaceuticals Inc | Mono- ili di-supstituisani indoli kao inhibitori replikacije denga virusa |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| BR112018009010B1 (pt) | 2015-11-03 | 2023-09-26 | Zoetis Services Llc | Uso de um compósito polimérico de sol-gel para prevenir ou tratar mastite em um mamífero não humano fêmea que tem um período de lactação e sistema para formar uma barreira física no canal ou cisterna da teta do dito mamífero |
| BR112018068676A2 (pt) | 2016-03-31 | 2019-01-15 | Janssen Pharmaceuticals Inc | derivados de indol substituídos como inibidores da replicação viral do dengue |
| SG11201808270PA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| TN2018000299A1 (en) | 2016-03-31 | 2020-01-16 | Takeda Pharmaceuticals Co | Heterocyclic compound. |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20190201A1 (es) | 2016-04-01 | 2019-02-05 | Amgen Inc | Receptores quimericos de flt3 y metodos de uso de los mismos |
| UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
| DK3436030T3 (da) | 2016-04-01 | 2022-11-21 | Kite Pharma Inc | Kimæriske receptorer og fremgangsmåder til anvendelse deraf |
| CN109069512B (zh) | 2016-04-01 | 2022-06-14 | 西格诺药品有限公司 | 取代的氨基嘌呤化合物、其组合物以及相关治疗方法 |
| AU2017240667C1 (en) | 2016-04-01 | 2022-11-24 | Kite Pharma, Inc. | Chimeric antigen and T cell receptors and methods of use |
| MA44502A (fr) | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| TWI771420B (zh) | 2017-05-22 | 2022-07-21 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之經取代之吲哚啉衍生物（一） |
-
2017
- 2017-03-31 BR BR112018068676A patent/BR112018068676A2/pt not_active Application Discontinuation
- 2017-03-31 HK HK19100496.8A patent/HK1258142A1/zh unknown
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/ko active Active
- 2017-03-31 HR HRP20210847TT patent/HRP20210847T1/hr unknown
- 2017-03-31 EA EA201892214A patent/EA201892214A1/ru unknown
- 2017-03-31 CR CR20180495A patent/CR20180495A/es unknown
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/hu unknown
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 SI SI201730800T patent/SI3436435T1/sl unknown
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/lt unknown
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/es unknown
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/es unknown
- 2017-03-31 ES ES17714750T patent/ES2882488T3/es active Active
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/da active
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/ja active Active
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/zh active Active
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en not_active Ceased
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/es unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/es unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017167950A1 (en) | 2017-10-05 |
| HK1258142A1 (zh) | 2019-11-08 |
| CA3013405A1 (en) | 2017-10-05 |
| JP6888021B2 (ja) | 2021-06-16 |
| HUE054936T2 (hu) | 2021-10-28 |
| LT3436435T (lt) | 2021-08-25 |
| KR20180130498A (ko) | 2018-12-07 |
| EA201892214A1 (ru) | 2019-03-29 |
| ES2882488T3 (es) | 2021-12-02 |
| ECSP18073245A (es) | 2018-10-31 |
| JP2019510024A (ja) | 2019-04-11 |
| ZA201806473B (en) | 2020-05-27 |
| SG11201808138YA (en) | 2018-10-30 |
| EP3436435B1 (en) | 2021-05-12 |
| HRP20210847T1 (hr) | 2021-07-23 |
| KR102359743B1 (ko) | 2022-02-07 |
| CO2018009559A2 (es) | 2018-09-20 |
| CN108884033B (zh) | 2021-03-09 |
| DK3436435T3 (da) | 2021-08-09 |
| IL261944A (en) | 2018-10-31 |
| PH12018502015A1 (en) | 2019-07-15 |
| US20190274999A1 (en) | 2019-09-12 |
| CR20180495A (es) | 2018-12-06 |
| MX2018011784A (es) | 2019-02-13 |
| CL2018002729A1 (es) | 2018-11-23 |
| CN108884033A (zh) | 2018-11-23 |
| SI3436435T1 (sl) | 2021-08-31 |
| US10646469B2 (en) | 2020-05-12 |
| AU2017242893A1 (en) | 2018-08-09 |
| EP3436435A1 (en) | 2019-02-06 |
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