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BR0110927A - Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer - Google Patents

Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer

Info

Publication number
BR0110927A
BR0110927A BR0110927-8A BR0110927A BR0110927A BR 0110927 A BR0110927 A BR 0110927A BR 0110927 A BR0110927 A BR 0110927A BR 0110927 A BR0110927 A BR 0110927A
Authority
BR
Brazil
Prior art keywords
antibody
nucleic acid
cancer
prophylaxis
vector
Prior art date
Application number
BR0110927-8A
Other languages
English (en)
Inventor
John Robert Maxwell Ellis
Linda Gillian Durrant
Original Assignee
Scancell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0011981A external-priority patent/GB0011981D0/en
Priority claimed from GB0020794A external-priority patent/GB0020794D0/en
Application filed by Scancell Ltd filed Critical Scancell Ltd
Publication of BR0110927A publication Critical patent/BR0110927A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467—Igs with modifications in the FR-residues only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"ANTICORPO, ACIDO NUCLEICO, VETOR, CéLULA, MéTODO DE FABRICAR UM ANTICORPO, COMPOSIçãO FARMACêUTICA, USO DE UM ANTICORPO OU DE UM áCIDO NUCLEICO, E, MéTODO PARA O TRATAMENTO OU PROFILAXIA DO CâNCER". A presente invenção fornece uma forma humanizada do anticorpo 340 obtenível da linhagem de célula depositada com a ECACC sob o número de acesso 97021428. Tais anticorpos verificou-se ter uma capacidade aumentada para matar células comparados com o anticorpo de murino 340. Também são fornecidos os ácidos nucleicos que codificam tais anticorpos, bem como o uso dos anticorpos na medicina, em particular no tratamento de câncer.
BR0110927-8A 2000-05-19 2001-05-21 Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer BR0110927A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0011981A GB0011981D0 (en) 2000-05-19 2000-05-19 Complementary determining regions of antibodies that show amino acid homology with peptide ligand
GB0020794A GB0020794D0 (en) 2000-08-24 2000-08-24 Humanised antibodies
PCT/GB2001/002226 WO2001088138A1 (en) 2000-05-19 2001-05-21 Humanised antibodies to the epidermal growth factor receptor

Publications (1)

Publication Number Publication Date
BR0110927A true BR0110927A (pt) 2003-03-11

Family

ID=26244299

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110927-8A BR0110927A (pt) 2000-05-19 2001-05-21 Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer

Country Status (12)

Country Link
US (3) US20040091485A1 (pt)
EP (1) EP1278851B1 (pt)
JP (1) JP2003533987A (pt)
KR (1) KR100480985B1 (pt)
CN (1) CN1239701C (pt)
AT (1) ATE316137T1 (pt)
AU (1) AU2001258567A1 (pt)
BR (1) BR0110927A (pt)
CA (1) CA2409361A1 (pt)
DE (1) DE60116753T2 (pt)
ES (1) ES2259030T3 (pt)
WO (1) WO2001088138A1 (pt)

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WO2001088138A1 (en) 2001-11-22
US20060240003A1 (en) 2006-10-26
CA2409361A1 (en) 2001-11-22
DE60116753T2 (de) 2006-09-14
US20080260735A1 (en) 2008-10-23
DE60116753D1 (de) 2006-04-06
ES2259030T3 (es) 2006-09-16
JP2003533987A (ja) 2003-11-18
CN1239701C (zh) 2006-02-01
ATE316137T1 (de) 2006-02-15
CN1432063A (zh) 2003-07-23

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