AR112473A1 - PROCESS TO PREPARE PURIFIED LEVODOPA AMIDE - Google Patents
PROCESS TO PREPARE PURIFIED LEVODOPA AMIDEInfo
- Publication number
- AR112473A1 AR112473A1 ARP180102330A AR112473A1 AR 112473 A1 AR112473 A1 AR 112473A1 AR P180102330 A ARP180102330 A AR P180102330A AR 112473 A1 AR112473 A1 AR 112473A1
- Authority
- AR
- Argentina
- Prior art keywords
- dopamide
- pharmaceutically acceptable
- prepare purified
- processes
- levodopa
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract 2
- -1 LEVODOPA AMIDE Chemical class 0.000 title 1
- 229960004502 levodopa Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procesos de purificación a gran escala de una sal de L-dopamida aceptable desde el punto de vista farmacéutico y procesos para elaborar una L-dopamida purificada aceptable desde el punto de vista farmacéutico, y sales de L-dopamida aceptables desde el punto de vista farmacéutico sustancialmente libres de L-dopa. Dichos procesos son útiles para proporcionar L-dopamida para el tratamiento de trastornos neurodegenerativos, tales como enfermedad de Parkinson.Large-scale purification processes of a pharmaceutically acceptable salt of L-dopamide and processes for making a purified pharmaceutically acceptable L-dopamide, and pharmaceutically acceptable salts of L-dopamide substantially free of L-dopa. Such processes are useful in providing L-dopamide for the treatment of neurodegenerative disorders, such as Parkinson's disease.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762548108P | 2017-08-21 | 2017-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112473A1 true AR112473A1 (en) | 2019-10-30 |
Family
ID=63683237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102330 AR112473A1 (en) | 2017-08-21 | 2018-08-15 | PROCESS TO PREPARE PURIFIED LEVODOPA AMIDE |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR112473A1 (en) |
| WO (1) | WO2019038638A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6591995B2 (en) | 2014-03-13 | 2019-10-16 | ニューロダーム リミテッドＮｅｕｒｏｄｅｒｍ Ｌｔｄ | Dopa decarboxylase inhibitor composition |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| WO2020035853A1 (en) * | 2018-08-15 | 2020-02-20 | Neuroderm, Ltd. | Process for preparing purified levodopamide free base |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069146A2 (en) * | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
| AU2016358511A1 (en) | 2015-11-24 | 2018-06-21 | Neuroderm Ltd. | Pharmaceutical compositions comprising levodopa amide and uses thereof |
-
2018
- 2018-08-15 AR ARP180102330 patent/AR112473A1/en unknown
- 2018-08-15 WO PCT/IB2018/056126 patent/WO2019038638A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019038638A1 (en) | 2019-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |