+

AR069896A1 - Plantas morfologicamente normales compuestas y fertiles que comprenden un gen epsp modificado - Google Patents

Plantas morfologicamente normales compuestas y fertiles que comprenden un gen epsp modificado

Info

Publication number
AR069896A1
AR069896A1 ARP070105643A ARP070105643A AR069896A1 AR 069896 A1 AR069896 A1 AR 069896A1 AR P070105643 A ARP070105643 A AR P070105643A AR P070105643 A ARP070105643 A AR P070105643A AR 069896 A1 AR069896 A1 AR 069896A1
Authority
AR
Argentina
Prior art keywords
gen
fertile plants
morphologically normal
normal composite
zinc
Prior art date
Application number
ARP070105643A
Other languages
English (en)
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR069896A1 publication Critical patent/AR069896A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se describen en la presente dedos de zinc que comprenden residuos coordinados de CCHC zinc. También se describen proteínas de dedo de zinc y proteínas de fusion que comprenden dichos dedos de CCHC zinc, así como los polinucleotidos que codifican dichas proteínas. También se describen métodos para usar dichas proteínas para la edicion de genes y la regulacion de genes.
ARP070105643A 2006-12-14 2007-12-14 Plantas morfologicamente normales compuestas y fertiles que comprenden un gen epsp modificado AR069896A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87491106P 2006-12-14 2006-12-14
US93249707P 2007-05-30 2007-05-30

Publications (1)

Publication Number Publication Date
AR069896A1 true AR069896A1 (es) 2010-03-03

Family

ID=39472493

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105643A AR069896A1 (es) 2006-12-14 2007-12-14 Plantas morfologicamente normales compuestas y fertiles que comprenden un gen epsp modificado

Country Status (21)

Country Link
US (3) US9187758B2 (es)
EP (5) EP2092068B1 (es)
JP (1) JP5632610B2 (es)
KR (4) KR101574529B1 (es)
CN (1) CN103613646B (es)
AR (1) AR069896A1 (es)
AU (1) AU2007334468B2 (es)
BR (1) BRPI0720048A8 (es)
CA (2) CA2669746C (es)
CO (1) CO6220864A2 (es)
CR (1) CR10775A (es)
DK (3) DK2092068T3 (es)
EG (1) EG26980A (es)
ES (1) ES2586210T3 (es)
HU (1) HUE029238T2 (es)
MX (1) MX2009006303A (es)
NZ (2) NZ597995A (es)
PT (4) PT2415873E (es)
SI (2) SI2415872T1 (es)
TW (1) TWI470079B (es)
WO (1) WO2008076290A2 (es)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP2092068B1 (en) * 2006-12-14 2014-10-08 Dow AgroSciences LLC Optimized non-canonical zinc finger proteins
SI2205749T1 (sl) 2007-09-27 2016-09-30 Dow Agrosciences, Llc Konstruirani proteini s cinkovim prstom, usmerjeni v 5-enolpiruvil-šikimat-3-fosfat-sintazne gene
WO2009120396A2 (en) * 2008-01-08 2009-10-01 The University Of California Compositions and methods for regulating erythropoientin expression and ameliorating anemia and stimulating erythropoiesis
CA2893175C (en) * 2008-06-10 2016-09-06 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
DK2370575T3 (en) * 2008-12-17 2018-02-05 Dow Agrosciences Llc TARGETED INTEGRATION IN THE ZP15 LOCUS
KR20100080068A (ko) * 2008-12-31 2010-07-08 주식회사 툴젠 신규한 징크 핑거 뉴클레아제 및 이의 용도
EP3156504B1 (en) 2009-08-11 2018-10-31 Sangamo Therapeutics, Inc. Organisms homozygous for targeted modification
US10172669B2 (en) 2009-10-09 2019-01-08 Ethicon Llc Surgical instrument comprising an energy trigger lockout
WO2011048600A1 (en) * 2009-10-21 2011-04-28 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
BR122019025207B1 (pt) 2009-10-22 2022-10-04 Sangamo Biosciences, Inc. Proteína de dedo de zinco de ocorrência não natural e proteína de fusão
CN102639695B (zh) * 2009-10-26 2015-01-21 独立行政法人农业生物资源研究所 转基因植物细胞的制造方法
CN104928256A (zh) 2009-11-24 2015-09-23 陶氏益农公司 Aad-12事件416、相关的转基因大豆系及其事件特异性鉴定
CN102725412B (zh) 2009-11-27 2017-09-22 巴斯夫植物科学有限公司 优化的内切核酸酶及其用途
CA2781835A1 (en) 2009-11-27 2011-06-03 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
JP5922029B2 (ja) 2009-11-27 2016-05-24 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー キメラエンドヌクレアーゼおよびその使用
US20110203012A1 (en) * 2010-01-21 2011-08-18 Dotson Stanton B Methods and compositions for use of directed recombination in plant breeding
CN106086047B (zh) * 2010-01-22 2021-07-06 陶氏益农公司 靶向基因组改造
EP2571512B1 (en) 2010-05-17 2017-08-23 Sangamo BioSciences, Inc. Novel dna-binding proteins and uses thereof
GB2480498A (en) 2010-05-21 2011-11-23 Ethicon Endo Surgery Inc Medical device comprising RF circuitry
EP2601297B1 (en) * 2010-08-02 2020-09-16 Cellectis Method for targeted genomic events in algae
MX348731B (es) 2010-12-03 2017-06-27 Ms Tech Llc Caso de tolerancia a herbicida 8264.44.06.1 agrupado, líneas de frijol de soya transgénicas relacionadas y detección de las mismas.
CA2820706C (en) 2010-12-03 2018-05-22 Ms Technologies, Llc Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells
CA2822958A1 (en) 2010-12-30 2012-07-05 Dow Agrosciences Llc Nucleic acid molecules that confer resistance to coleopteran pests
RU2644669C2 (ru) 2010-12-30 2018-02-13 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Молекулы нуклеиновой кислоты, которые воздействуют на субъединицу с вакуолярной атфазы и придают устойчивость к жесткокрылым насекомым-вредителям
EP3375878A1 (en) 2010-12-30 2018-09-19 Dow AgroSciences LLC Nucleic acid molecules that target the vacuolar atphase h subunit and confer resistance to coleopteran pests
UY34014A (es) 2011-04-15 2012-11-30 Dow Agrosciences Llc Genes sintéticos para expresar proteínas en células de maíz, construcciones, plantas transgénicas, métodos para controlar pestes y composiciones
BR102012019434B1 (pt) 2011-07-26 2021-11-09 Dow Agrosciences Llc Métodos de controle de pestes, de insetos, molécula e sequência de dna diagnóstica para o evento de soja 9582.814.19.1
BR122014004140B8 (pt) * 2011-08-22 2023-03-28 Bayer Cropscience Ag Vetor recombinante ou construção recombinante, bem como métodos para obter e produzir uma planta de algodão ou célula vegetal tolerante a um inibidor de hppd, e para cultivar um campo de plantas de algodão
US9333025B2 (en) 2011-10-24 2016-05-10 Ethicon Endo-Surgery, Llc Battery initialization clip
US9458205B2 (en) 2011-11-16 2016-10-04 Sangamo Biosciences, Inc. Modified DNA-binding proteins and uses thereof
EP2612918A1 (en) 2012-01-06 2013-07-10 BASF Plant Science Company GmbH In planta recombination
CN107043816A (zh) 2012-01-23 2017-08-15 陶氏益农公司 除草剂耐受性棉花事件pDAB4468.19.10.3
UY34606A (es) 2012-02-01 2013-09-02 Dow Agrosciences Llc Péptidos sintéticos de tránsito al cloroplastos derivados de brassica.
RU2662672C2 (ru) 2012-02-02 2018-07-26 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и относящиеся к ним способы
CN108285491B (zh) 2012-02-29 2021-08-10 桑格摩生物科学股份有限公司 治疗亨廷顿氏病的方法和组合物
BR112014026203A2 (pt) 2012-04-23 2017-07-18 Bayer Cropscience Nv engenharia do genoma direcionado nas plantas
MX344903B (es) * 2012-05-02 2017-01-11 Dow Agrosciences Llc Modificación dirigida de deshidrogenasa de malato.
EP2847338B1 (en) * 2012-05-07 2018-09-19 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration of transgenes
CA2881783A1 (en) * 2012-08-13 2014-02-20 The Regents Of The University Of California Methods and systems for detecting biological components
AR092482A1 (es) 2012-09-07 2015-04-22 Dow Agrosciences Llc Enriquecimiento de la clasificacion de las celulas activadas por fluorescencia (facs) para generar plantas
UA118090C2 (uk) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
UA119135C2 (uk) * 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб отримання трансгенної рослини
RU2665811C2 (ru) 2012-09-07 2018-09-04 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Локусы fad3 для выполнения операций и соответствующие связывающиеся со специфическими сайтами-мишенями белки, способные к вызову направленных разрывов
JP6473419B2 (ja) 2012-12-13 2019-02-20 ダウ アグロサイエンシィズ エルエルシー 部位特異的ヌクレアーゼ活性のｄｎａ検出方法
CA2895117A1 (en) 2012-12-13 2014-06-19 James W. Bing Precision gene targeting to a particular locus in maize
CN105121631B (zh) 2013-02-20 2019-04-19 瑞泽恩制药公司 大鼠的遗传修饰
AU2014248208C1 (en) 2013-04-05 2023-04-27 Corteva Agriscience Llc Methods and compositions for integration of an exogenous sequence within the genome of plants
KR102186281B1 (ko) 2013-04-16 2020-12-03 리제너론 파마슈티칼스 인코포레이티드 랫트 게놈의 표적화된 변형
WO2015031619A1 (en) 2013-08-28 2015-03-05 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
AU2014315335B2 (en) 2013-09-04 2017-08-24 Corteva Agriscience Llc Rapid targeting analysis in crops for determining donor insertion
CA2926536C (en) 2013-11-04 2024-01-30 Dow Agrosciences Llc Optimal soybean loci for targeted transgene integration
JP6634022B2 (ja) 2013-11-04 2020-01-22 ダウ アグロサイエンシィズ エルエルシー 最適なダイズ遺伝子座
MX360318B (es) 2013-11-04 2018-10-29 Dow Agrosciences Llc Óptimos loci de maíz.
AU2014341929B2 (en) 2013-11-04 2017-11-30 Corteva Agriscience Llc Optimal maize loci
DK3068881T3 (en) * 2013-11-13 2019-04-15 Childrens Medical Center NUCLEASE-MEDIATED REGULATION OF GENEPRESSION
PT3080279T (pt) 2013-12-11 2018-12-17 Regeneron Pharma Métodos e composições para a modificação direcionada de um genoma
JP6174811B2 (ja) 2013-12-11 2017-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ゲノムの標的改変のための方法及び組成物
US10683513B2 (en) 2013-12-31 2020-06-16 Dow Agrosciences Llc Tissue-specific expression and hybrid plant production
US10774338B2 (en) 2014-01-16 2020-09-15 The Regents Of The University Of California Generation of heritable chimeric plant traits
JP6688231B2 (ja) 2014-06-06 2020-04-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 標的遺伝子座を修飾するための方法及び組成物
ES2781323T3 (es) 2014-06-23 2020-09-01 Regeneron Pharma Montaje de ADN mediado por nucleasas
SG10201911411YA (en) 2014-06-26 2020-02-27 Regeneron Pharma Methods and compositions for targeted genetic modifications and methods of use
EP3166964A1 (en) 2014-07-08 2017-05-17 Vib Vzw Means and methods to increase plant yield
US20170142942A1 (en) 2014-07-14 2017-05-25 Washington State University Nanos knock-out that ablates germline cells
BR112017001601A2 (pt) 2014-09-07 2017-11-21 Selecta Biosciences Inc métodos e composições para atenuar as respostas imunes do vetor de transferência antiviral de modulação da expressão genética
PT3207124T (pt) 2014-10-15 2019-08-27 Regeneron Pharma Métodos e composições para a produção ou conservação de células pluripotentes
US10883111B2 (en) 2014-11-27 2021-01-05 Danziger Innovations Ltd. Nucleic acid constructs for genome editing
BR112017013104A2 (pt) 2014-12-19 2018-05-15 Regeneron Pharma métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano.
US10159524B2 (en) 2014-12-22 2018-12-25 Ethicon Llc High power battery powered RF amplifier topology
CN107530654A (zh) 2015-02-04 2018-01-02 加利福尼亚大学董事会 通过在离散实体中条形码化对核酸进行测序
US20160281055A1 (en) 2015-03-20 2016-09-29 Dow Agrosciences Llc Incorporation of phosphatidylcholine in a media composition
JP2018513681A (ja) 2015-03-31 2018-05-31 エクセリゲン サイエンティフィック, インコーポレイテッドExeligen Scientific, Inc. 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
US10314638B2 (en) 2015-04-07 2019-06-11 Ethicon Llc Articulating radio frequency (RF) tissue seal with articulating state sensing
EP4361279A3 (en) 2015-08-06 2024-07-17 The Curators of the University of Missouri Pathogen-resistant animals having modified cd163 genes
EP3332014A4 (en) 2015-08-07 2019-01-23 Commonwealth Scientific and Industrial Research Organisation METHOD FOR PRODUCING ANIMAL WITH GENETIC GLAND CARBON MODIFICATION
US10959771B2 (en) 2015-10-16 2021-03-30 Ethicon Llc Suction and irrigation sealing grasper
BR112018010499A8 (pt) 2015-11-24 2019-02-26 Commw Scient Ind Res Org método para replicar um vírus, vírus, método para produzir uma composição de vacina, composição de vacina, população de células in vitro, método para produzir uma população de células, e população de células
WO2017088017A1 (en) 2015-11-24 2017-06-01 Commonwealth Scientific And Industrial Research Organisation Production of viruses in avian eggs
US10959806B2 (en) 2015-12-30 2021-03-30 Ethicon Llc Energized medical device with reusable handle
US10856934B2 (en) 2016-04-29 2020-12-08 Ethicon Llc Electrosurgical instrument with electrically conductive gap setting and tissue engaging members
US10987156B2 (en) 2016-04-29 2021-04-27 Ethicon Llc Electrosurgical instrument with electrically conductive gap setting member and electrically insulative tissue engaging members
US10548302B2 (en) 2016-07-29 2020-02-04 Regeneron Pharmaceuticals, Inc. Fibrillin-1 mutations for modeling neonatal progeroid syndrome with congenital lipodystrophy
US10751117B2 (en) 2016-09-23 2020-08-25 Ethicon Llc Electrosurgical instrument with fluid diverter
CN118325899A (zh) 2017-01-23 2024-07-12 瑞泽恩制药公司 Hsd17b13变体及其应用
US11033325B2 (en) 2017-02-16 2021-06-15 Cilag Gmbh International Electrosurgical instrument with telescoping suction port and debris cleaner
US10799284B2 (en) 2017-03-15 2020-10-13 Ethicon Llc Electrosurgical instrument with textured jaws
US11497546B2 (en) 2017-03-31 2022-11-15 Cilag Gmbh International Area ratios of patterned coatings on RF electrodes to reduce sticking
WO2018195129A1 (en) 2017-04-17 2018-10-25 University Of Maryland, College Park Embryonic cell cultures and methods of using the same
US10603117B2 (en) 2017-06-28 2020-03-31 Ethicon Llc Articulation state detection mechanisms
RS67096B1 (sr) 2017-08-29 2025-09-30 Kws Saat Se & Co Kgaa Unapređeni sistem plavog aleurona i drugi sistemi segregacije
US11484358B2 (en) 2017-09-29 2022-11-01 Cilag Gmbh International Flexible electrosurgical instrument
SG11202000771UA (en) 2017-09-29 2020-04-29 Regeneron Pharma Non-human animals comprising a humanized ttr locus and methods of use
US11490951B2 (en) 2017-09-29 2022-11-08 Cilag Gmbh International Saline contact with electrodes
US11033323B2 (en) 2017-09-29 2021-06-15 Cilag Gmbh International Systems and methods for managing fluid and suction in electrosurgical systems
GB201716254D0 (en) * 2017-10-05 2017-11-22 Univ Leuven Kath Live-attenuated flaviruses with heterologous antigens
WO2019075360A1 (en) 2017-10-13 2019-04-18 Selecta Biosciences, Inc. METHODS AND COMPOSITIONS FOR MITIGATING ANTI-VECTOR VIRAL TRANSFER IGM RESPONSES
IL276957B2 (en) 2018-02-26 2023-12-01 Antolrx Inc Tolerogenic liposomes and methods of using them
US20210037798A1 (en) 2018-03-20 2021-02-11 Tsinghua University Alzheimers disease animal model and use thereof
EP3781677A4 (en) 2018-04-16 2022-01-19 University of Massachusetts COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING
WO2020036653A2 (en) * 2018-04-25 2020-02-20 The Regents Of The University Of California Improved method for homology directed repair in cells
GB201809273D0 (en) 2018-06-06 2018-07-25 Vib Vzw Novel mutant plant cinnamoyl-coa reductase proteins
GB201820109D0 (en) 2018-12-11 2019-01-23 Vib Vzw Plants with a lignin trait and udp-glycosyltransferase mutation
SG11202105189RA (en) 2018-12-20 2021-06-29 Regeneron Pharma Nuclease-mediated repeat expansion
IL286865B2 (en) 2019-04-03 2025-08-01 Regeneron Pharma Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
CN113795588B (zh) 2019-04-04 2025-02-25 瑞泽恩制药公司 用于在靶向性载体中无瘢痕引入靶向修饰的方法
JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子１２遺伝子座を含む非ヒト動物
CN114206396A (zh) 2019-05-28 2022-03-18 西莱克塔生物科技公司 用于减弱抗病毒转移载体免疫应答的方法和组合物
CA3137761A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
WO2020244759A1 (en) 2019-06-05 2020-12-10 Klemm & Sohn Gmbh & Co. Kg New plants having a white foliage phenotype
MX2021015122A (es) 2019-06-07 2022-04-06 Regeneron Pharma Animales no humanos que comprenden un locus de albumina humanizado.
CA3137765A1 (en) 2019-06-14 2020-12-17 Regeneron Pharmaceuticals, Inc. Models of tauopathy
WO2020257684A1 (en) 2019-06-20 2020-12-24 University Of Massachusetts Compositions and methods for improved gene editing
EP4002993A4 (en) 2019-07-30 2024-01-10 Pairwise Plants Services, Inc. MORPHOGENIC REGULATORS AND METHODS OF USE
WO2021028359A1 (en) 2019-08-09 2021-02-18 Sangamo Therapeutics France Controlled expression of chimeric antigen receptors in t cells
EP4054651A1 (en) 2019-11-08 2022-09-14 Regeneron Pharmaceuticals, Inc. Crispr and aav strategies for x-linked juvenile retinoschisis therapy
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
WO2021178556A1 (en) 2020-03-04 2021-09-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for sensitization of tumor cells to immune therapy
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CA3182607A1 (en) 2020-06-30 2022-01-06 Erik Hans MANTING Use of leukemia-derived cells in ovarian cancer vaccines
MX2023005665A (es) 2020-11-16 2023-08-01 Pig Improvement Co Uk Ltd Animales resistentes a la influenza a que tienen genes de anp32 editados.
WO2022157715A1 (en) 2021-01-22 2022-07-28 Dcprime B.V. Methods of tumor vaccination
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
WO2023064367A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
US11957342B2 (en) 2021-11-01 2024-04-16 Cilag Gmbh International Devices, systems, and methods for detecting tissue and foreign objects during a surgical operation
WO2023086847A1 (en) 2021-11-10 2023-05-19 Encodia, Inc. Methods for barcoding macromolecules in individual cells
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023129974A1 (en) 2021-12-29 2023-07-06 Bristol-Myers Squibb Company Generation of landing pad cell lines
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2023172624A1 (en) 2022-03-09 2023-09-14 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
EP4522726A1 (en) 2022-05-09 2025-03-19 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
EP4561636A1 (en) 2022-07-29 2025-06-04 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
IL318553A (en) 2022-08-05 2025-03-01 Regeneron Pharma Aggregation-resistant TDP-43 variants
KR20250116795A (ko) 2022-11-14 2025-08-01 리제너론 파마슈티칼스 인코포레이티드 별아교세포로의 섬유아세포 성장 인자 수용체 3-매개된 전달을 위한 조성물 및 방법
WO2024161358A1 (en) 2023-02-01 2024-08-08 Dlf Seeds A/S Beet yellows virus resistance
WO2024163615A1 (en) 2023-02-02 2024-08-08 University Of Florida Research Foundation, Incorporated Brain-derived neurotrophic factor-nano luciferase transgenic rodents and methods of use thereof
US12239091B2 (en) 2023-03-27 2025-03-04 Redsea Science And Technology Inc. Tomato plant designated ‘MX20-06’
CN116491599A (zh) * 2023-06-26 2023-07-28 云南大台农台标农业科技有限公司 一种复合菌剂及其在猪饲料中的应用
WO2025128981A1 (en) 2023-12-14 2025-06-19 Sohm, Inc. Compositions and methods for genome editing

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
EP0222493A1 (en) 1985-10-04 1987-05-20 Lubrizol Genetics Inc. TR-based sub-TI plasmids
US5422251A (en) 1986-11-26 1995-06-06 Princeton University Triple-stranded nucleic acids
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5550318A (en) * 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
EP0604662B1 (en) 1992-07-07 2008-06-18 Japan Tobacco Inc. Method of transforming monocotyledon
EP0770129B1 (en) 1994-01-18 2005-11-23 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6140466A (en) * 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6242568B1 (en) 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5585245A (en) 1994-04-22 1996-12-17 California Institute Of Technology Ubiquitin-based split protein sensor
EP2022856B1 (en) 1994-08-20 2011-09-14 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
US5789538A (en) 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US5925523A (en) 1996-08-23 1999-07-20 President & Fellows Of Harvard College Intraction trap assay, reagents and uses thereof
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
GB2338237B (en) 1997-02-18 2001-02-28 Actinova Ltd In vitro peptide or protein expression library
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AR014491A1 (es) 1998-01-29 2001-02-28 Dow Agrosciences Llc Metodo para obtener plantas transgenicas fertiles de gossypium hirsutum.
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
DE69942334D1 (de) * 1998-03-02 2010-06-17 Massachusetts Inst Technology Poly-zinkfinger-proteine mit verbesserten linkern
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US20030104526A1 (en) * 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
EP1276869A2 (en) 2000-01-21 2003-01-22 The Scripps Research Institute Methods and compositions to modulate expression in plants
CA2398155C (en) 2000-01-24 2011-07-19 Sangamo Biosciences, Inc. Methods and compositions for linking binding domains in nucleic acid binding proteins
US20020061512A1 (en) 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
AU5391401A (en) 2000-04-28 2001-11-12 Sangamo Biosciences Inc Targeted modification of chromatin structure
US20030044787A1 (en) 2000-05-16 2003-03-06 Joung J. Keith Methods and compositions for interaction trap assays
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
WO2002026960A2 (en) 2000-09-29 2002-04-04 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
US9234187B2 (en) 2001-01-22 2016-01-12 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
JP2005500061A (ja) 2001-08-20 2005-01-06 ザ スクリップス リサーチ インスティテュート Ｃｎｎについての亜鉛フィンガー結合ドメイン
AU2003251286B2 (en) 2002-01-23 2007-08-16 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
EP2368982A3 (en) 2002-03-21 2011-10-12 Sangamo BioSciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
WO2004037977A2 (en) 2002-09-05 2004-05-06 California Institute Of Thechnology Use of chimeric nucleases to stimulate gene targeting
WO2005014794A2 (en) * 2003-08-07 2005-02-17 Duke University Generation of low phytate plants by molecular disruption of inositol polyphosphate kinases
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
DK2927318T3 (da) * 2003-08-08 2020-08-03 Sangamo Therapeutics Inc Fremgangsmåde og sammensætninger til målrettet spaltning og rekombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7407776B2 (en) * 2003-09-19 2008-08-05 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
WO2005078079A1 (en) * 2004-02-09 2005-08-25 Pioneer Hi-Bred International, Inc. Phytate polynucleotides and methods of use
WO2005099771A2 (en) 2004-04-08 2005-10-27 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathic and neurodegenerative conditions
PT1740039E (pt) 2004-04-30 2012-08-27 Dow Agrosciences Llc Novos genes de resistência a herbicida
AR050866A1 (es) * 2004-09-09 2006-11-29 Dow Agrosciences Llc Genes de inositol polifosfato 2-quinasa y usos de los mismos
AU2006272634B2 (en) 2005-07-26 2013-01-24 Sangamo Therapeutics, Inc. Targeted integration and expression of exogenous nucleic acid sequences
DK2049663T3 (en) * 2006-08-11 2015-06-01 Dow Agrosciences Llc ZINC FINGER NUCLEASE-MEDIATED HOMOLOGOUS RECOMBINATION
EP2092068B1 (en) * 2006-12-14 2014-10-08 Dow AgroSciences LLC Optimized non-canonical zinc finger proteins

Also Published As

Publication number Publication date
KR20160044066A (ko) 2016-04-22
KR20150139631A (ko) 2015-12-11
MX2009006303A (es) 2009-10-21
PT2415873E (pt) 2015-03-31
CA2669746C (en) 2017-05-16
WO2008076290A3 (en) 2008-11-20
US20160130314A1 (en) 2016-05-12
EP2415873A1 (en) 2012-02-08
EP2092068A2 (en) 2009-08-26
EP2415872B1 (en) 2016-05-11
EP3070169B1 (en) 2018-05-09
US10662434B2 (en) 2020-05-26
DK2415872T3 (en) 2016-08-22
EP2415873B1 (en) 2015-01-21
EP2412812B1 (en) 2015-02-11
CR10775A (es) 2009-08-12
CN103613646A (zh) 2014-03-05
PT2092068E (pt) 2015-01-14
TW200844233A (en) 2008-11-16
JP5632610B2 (ja) 2014-11-26
DK2092068T3 (en) 2015-01-12
KR101613624B1 (ko) 2016-04-29
KR101574529B1 (ko) 2015-12-08
AU2007334468B2 (en) 2013-02-07
CA2962856A1 (en) 2008-06-26
BRPI0720048A8 (pt) 2023-02-07
HUE029238T2 (en) 2017-02-28
US9187758B2 (en) 2015-11-17
DK2412812T3 (en) 2015-05-26
EP3070169A1 (en) 2016-09-21
CN103613646B (zh) 2020-12-01
WO2008076290A2 (en) 2008-06-26
EG26980A (en) 2015-03-01
KR101520507B1 (ko) 2015-05-29
CA2669746A1 (en) 2008-06-26
TWI470079B (zh) 2015-01-21
EP2092068B1 (en) 2014-10-08
JP2010512745A (ja) 2010-04-30
NZ597995A (en) 2013-05-31
BRPI0720048A2 (pt) 2013-12-31
EP2415872A1 (en) 2012-02-08
US8921112B2 (en) 2014-12-30
US20080182332A1 (en) 2008-07-31
PT2415872T (pt) 2016-07-07
ES2586210T3 (es) 2016-10-13
AU2007334468A1 (en) 2008-06-26
KR20150016364A (ko) 2015-02-11
US20090111188A1 (en) 2009-04-30
SI2415872T1 (sl) 2016-09-30
SI2092068T1 (sl) 2015-06-30
EP2412812A1 (en) 2012-02-01
PT2412812E (pt) 2015-04-30
KR101723350B1 (ko) 2017-04-05
KR20090088904A (ko) 2009-08-20
CO6220864A2 (es) 2010-11-19
NZ576800A (en) 2013-02-22

Similar Documents

Publication Publication Date Title
AR069896A1 (es) Plantas morfologicamente normales compuestas y fertiles que comprenden un gen epsp modificado
CL2010001413A1 (es) Celula de planta transgenica que comprende un polinucleotido que codifica una proteina que posee actividad fosfinotricina acetiltransferasa; metodo para usar el gen dsm-2 como marcador seleccionable; y procedimiento para producir plantas tolerantes a herbicidas.
BR112018075099A2 (pt) novos loci genéticos associados a resistência a doença em soja
AR068559A1 (es) Proteinas de dedo de zinc obtenidas por ingenieria dirigidas a genes de 5-enolpiruvilshikimato-3-fosfatosintetasa
AR065244A1 (es) Genes de tipo alanina racemasa para el control de nematodos y metodos para su uso en plantas
MX2016006513A (es) Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion.
BRPI0720099A2 (pt) Pilha de células de combustível e vedação para uma pilha de células de combustível, bem como processo de produção para a mesma
UY35816A (es) ?locus óptimos de la soja?.
EP1998710A4 (en) EXPRESSION CODES FOR MICRO PARTICLE MARKINGS BASED ON SIGNATURES
MX341884B (es) Anticuerpos anti-antigeno de maduracion de celulas b (bcma).
BR112012022874A2 (pt) composições de lacas em pós curáveis por calor, seu processo de produção e uso das mesma
WO2008019364A3 (en) Method, system, and computer readable storage for affiliate group searching
MX2009007480A (es) Microcápsulas para regímenes alimenticios vegetarianos.
MX2015012875A (es) Composiciones de cultivo celular con antioxidantes y metodos para la produccion de polipeptidos.
BR112014029346A2 (pt) sistema e método implementado por computador para a montagem de um plano de tratamento médico
CR8914S (es) Base y cubierta para marmita al vapor
DK2076935T3 (da) Bærebeholder til en strømforsyningsenhed med brændselsceller
BRPI0702163A (pt) composições de toner e métodos
UY34653A (es) ?composiciones herbicidas que proporcionan control amplio de malezas con fitotoxicidad resultante reducida para cultivares?.
WO2011094079A3 (en) Improving pre-route and post-route net correlation with defined patterns
BR112019013005A2 (pt) espécie de metschnikowia isolada, método para produzir xilitol, xilitol bioderivado e composição
WO2009115826A3 (en) Apparatus and methods for game conversion
CR20140061A (es) Regulador de corriente
WO2008126078A3 (en) System and method for generating a finite elements model of a pcb
EA201071408A1 (ru) Способ получения однодольных растений с мужской стерильностью

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载