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AR056087A1 - DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS - Google Patents

DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS

Info

Publication number
AR056087A1
AR056087A1 ARP060104173A ARP060104173A AR056087A1 AR 056087 A1 AR056087 A1 AR 056087A1 AR P060104173 A ARP060104173 A AR P060104173A AR P060104173 A ARP060104173 A AR P060104173A AR 056087 A1 AR056087 A1 AR 056087A1
Authority
AR
Argentina
Prior art keywords
neuroquine
azetidine
derivatives
compound
formula
Prior art date
Application number
ARP060104173A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR056087A1 publication Critical patent/AR056087A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas que los contienen, usos en el tratamiento de desordenes gastrointestinales y métodos de preparacion. Reivindicacion 1: Un compuesto de formula (1) donde Het es como se muestra en el compuesto de formula (2) donde X es C u O; Y es C u O; con la condicion de que o X o Y sea O; R1 y R2 son, de manera independiente, H o alquilo C1-3; y además sus sales aceptables para uso farmacéutico y farmacologico, y enantiomeros del compuesto de formula (1) y sus sales.Pharmaceutical compositions containing them, uses in the treatment of gastrointestinal disorders and methods of preparation. Claim 1: A compound of formula (1) wherein Het is as shown in the compound of formula (2) wherein X is C or O; Y is C or O; with the proviso that either X or Y is O; R1 and R2 are independently H or C1-3 alkyl; and also its acceptable salts for pharmaceutical and pharmacological use, and enantiomers of the compound of formula (1) and its salts.

ARP060104173A 2005-09-29 2006-09-25 DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS AR056087A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0502151 2005-09-29

Publications (1)

Publication Number Publication Date
AR056087A1 true AR056087A1 (en) 2007-09-19

Family

ID=37900051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104173A AR056087A1 (en) 2005-09-29 2006-09-25 DERIVATIVES OF AZETIDINE AS NK NEUROQUINE RECEIVER ANTAGONISTS

Country Status (4)

Country Link
AR (1) AR056087A1 (en)
TW (1) TW200745133A (en)
UY (1) UY29817A1 (en)
WO (1) WO2007037742A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136325A1 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 2
US8106208B2 (en) * 2006-05-18 2012-01-31 Albireo Ab Benzamide compounds that act as NK receptor antagonists
WO2007136326A2 (en) * 2006-05-18 2007-11-29 Astrazeneca Ab ) t e text as een esta s e y t s ut o ty to rea as o ows: 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 3
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080056A1 (en) 2010-02-01 2012-03-07 Novartis Ag CICLOHEXIL-AMIDA DERIVATIVES AS ANTAGONISTS OF CRF RECEIVERS
AR080055A1 (en) 2010-02-01 2012-03-07 Novartis Ag DERIVATIVES OF PIRAZOLO- [5,1-B] -OXAZOL AS ANTAGONISTS OF THE RECEIVERS OF CRF -1
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
GB9601202D0 (en) * 1996-01-22 1996-03-20 Pfizer Ltd Piperidones
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
IL140770A0 (en) * 1998-07-10 2002-02-10 Astrazeneca Ab N-substituted naphthalene carboxamides as neurokinin-receptor antagonists
GB9922519D0 (en) * 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9826941D0 (en) * 1998-12-09 1999-02-03 Zeneca Pharmaceuticals Compounds
JP2006511500A (en) * 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ-Aminoamide-based chemokine receptor activity modulator
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds

Also Published As

Publication number Publication date
UY29817A1 (en) 2007-04-30
WO2007037742A1 (en) 2007-04-05
TW200745133A (en) 2007-12-16

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