NO20081684L - En forbedret fremgangsmate for fremstilling av okazolidin-beskyttende aminodiolforbindelser anvendbare som mellomprodukter for Florfenicol - Google Patents

En forbedret fremgangsmate for fremstilling av okazolidin-beskyttende aminodiolforbindelser anvendbare som mellomprodukter for Florfenicol

Info

Publication number: NO20081684L
Authority: NO; Norway
Prior art keywords: florfenicol; preparation; intermediates; okazolidine; improved process
Prior art date: 2005-09-07

Application number

NO20081684A

Other languages

English (en)

Norwegian (no)

Inventor

James C Towson

Original Assignee

Schering Plough Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-07

Filing date

2008-04-04

Publication date

2008-06-05

2008-04-04 Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd

2008-06-05 Publication of NO20081684L publication Critical patent/NO20081684L/no

Links

238000000034 method Methods 0.000 title abstract 3
AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 title abstract 2
229960003760 florfenicol Drugs 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO20081684A 2005-09-07 2008-04-04 En forbedret fremgangsmate for fremstilling av okazolidin-beskyttende aminodiolforbindelser anvendbare som mellomprodukter for Florfenicol NO20081684L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71468505P	2005-09-07	2005-09-07
PCT/US2006/034219 WO2007030386A2 (fr)	2005-09-07	2006-08-31	Procede ameliorer de preparation de composes aminodiols a protection oxazolidine utiles comme intermediaires pour florfenicole

Publications (1)

Publication Number	Publication Date
NO20081684L true NO20081684L (no)	2008-06-05

Family

ID=37684114

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO20081684A NO20081684L (no)	2005-09-07	2008-04-04	En forbedret fremgangsmate for fremstilling av okazolidin-beskyttende aminodiolforbindelser anvendbare som mellomprodukter for Florfenicol
NO20081685A NO20081685L (no)	2005-09-07	2008-04-04	Fremgangsmate for fremstilling oksazolidin-beskyttelse aminodolforbindelser anvendbare som mellomprodukter for Florfenicol
NO20081686A NO20081686L (no)	2005-09-07	2008-04-04	Fremgangsmate for fremstilling av esteroksazolidinforbindelser, og deres omdannelse til Florfnicol

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO20081685A NO20081685L (no)	2005-09-07	2008-04-04	Fremgangsmate for fremstilling oksazolidin-beskyttelse aminodolforbindelser anvendbare som mellomprodukter for Florfenicol
NO20081686A NO20081686L (no)	2005-09-07	2008-04-04	Fremgangsmate for fremstilling av esteroksazolidinforbindelser, og deres omdannelse til Florfnicol

Country Status (19)

Country	Link
US (3)	US20070055066A1 (fr)
EP (3)	EP1928820B1 (fr)
JP (3)	JP2009507842A (fr)
KR (3)	KR101408596B1 (fr)
CN (3)	CN101300238A (fr)
AU (3)	AU2006287716A1 (fr)
BR (3)	BRPI0615764A2 (fr)
CA (3)	CA2621961A1 (fr)
EC (3)	ECSP088266A (fr)
ES (1)	ES2459205T3 (fr)
IL (3)	IL189829A0 (fr)
MX (3)	MX2008003188A (fr)
NO (3)	NO20081684L (fr)
RU (3)	RU2008112950A (fr)
SI (1)	SI1928820T1 (fr)
TW (3)	TW200800924A (fr)
UA (1)	UA93212C2 (fr)
WO (3)	WO2007030385A2 (fr)
ZA (3)	ZA200802047B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20050386A1 (es)	2003-05-29	2005-06-23	Schering Plough Ltd	Composiciones farmaceuticas de florfenicol
EP1785414A1 (fr) *	2005-11-09	2007-05-16	KRKA, tovarna zdravil, d.d., Novo mesto	Procédé pour la synthèse des intermédiaires du chloramphenicol ou de ses analogues
EP2102154A1 (fr) *	2006-12-13	2009-09-23	Schering-Plough Ltd.	Promédicaments solubles dans l'eau de chloramphénicol, thiamphénicol et analogues de ceux-ci
AU2008279308A1 (en) *	2007-07-25	2009-01-29	Intervet International B.V.	Process for preparing oxazolidine-and oxazolidinone-aminodiols and related intermediates
PE20091171A1 (es) *	2007-12-14	2009-08-03	Schering Plough Ltd	Proceso para recuperar florfenicol y analogos de florfenicol
EP2321269B1 (fr) *	2008-07-30	2018-09-19	Intervet International B.V.	Procede de preparation de composes aminodiol d'oxazoline proteges utiles comme produits intermediaires dans la production de florfenicol
CN101941927B (zh) *	2010-09-28	2012-10-03	湖北美天生物科技有限公司	氟苯尼考中间体(1r,2r)-2-氨基-1–(4-(甲砜基)苯基)-1,3-丙二醇的合成方法
CN103649097A (zh)	2011-05-02	2014-03-19	佐蒂斯有限责任公司	用作抗菌剂的新型头孢菌素类
CN103254103A (zh) *	2013-06-05	2013-08-21	南通金利油脂工业有限公司	氟化剂在制备氟苯尼考工艺中的应用
CN103965085B (zh) *	2014-04-17	2016-02-24	上海恒晟药业有限公司	一种取代1,2-氨基醇药物的制备方法
CN106278964B (zh) *	2016-07-31	2018-01-16	浙江润康药业有限公司	氟苯尼考的制备方法
CN111500652B (zh) *	2019-01-30	2024-03-26	苏州引航生物科技有限公司	一种制备氟苯尼考的方法
CN110302163A (zh) *	2019-07-23	2019-10-08	东莞正大康地饲料有限公司	一种氟苯尼考可溶性粉及其制备方法
CN110773207A (zh) *	2019-09-25	2020-02-11	陈红菊	一种在室温且无光条件下可完全分解甲醛的冷触媒材料及其制备方法
CN111423391A (zh) *	2020-03-18	2020-07-17	浙江康牧药业有限公司	一种氟苯尼考中间体的制备方法
CN113402475A (zh) *	2021-06-07	2021-09-17	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4002637A (en) *	1973-07-09	1977-01-11	Rohm And Haas Company	Oxazolidine, oxazolidine-containing condensation and addition polymers and methods of producing them
EP0677511A3 (fr) *	1983-06-02	1996-07-24	Zambon Spa	Intermédiaires pour la préparation des dérivés de 1-phényl-1-hydroxy-2-amino-3-fluoropropane.
IT1237798B (it) *	1989-10-20	1993-06-17	Zambon Spa	Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
WO1994004523A1 (fr) *	1992-08-21	1994-03-03	Japan Tobacco Inc.	Compose dioxacycloalcane a activite inhibitrice de la renine
US5663361A (en) *	1996-08-19	1997-09-02	Schering Corporation	Process for preparing intermediates to florfenicol
JP2001240571A (ja) *	2000-03-01	2001-09-04	Udagawa Reiko	フッ素アルコールの製造方法
KR20040091698A (ko) *	2002-03-08	2004-10-28	쉐링-플라우 리미티드.	신규한 플로르페니콜형 항생제
US7126005B2 (en) *	2003-10-06	2006-10-24	Aurobindo Pharma Limited	Process for preparing florfenicol

2006
- 2006-08-31 BR BRPI0615764-5A patent/BRPI0615764A2/pt not_active IP Right Cessation
- 2006-08-31 CN CNA2006800412359A patent/CN101300238A/zh active Pending
- 2006-08-31 RU RU2008112950/04A patent/RU2008112950A/ru not_active Application Discontinuation
- 2006-08-31 BR BRPI0615767-0A patent/BRPI0615767A2/pt not_active IP Right Cessation
- 2006-08-31 WO PCT/US2006/034217 patent/WO2007030385A2/fr active Application Filing
- 2006-08-31 CA CA002621961A patent/CA2621961A1/fr not_active Abandoned
- 2006-08-31 KR KR1020087005920A patent/KR101408596B1/ko not_active Expired - Fee Related
- 2006-08-31 EP EP06824884.8A patent/EP1928820B1/fr active Active
- 2006-08-31 SI SI200631769T patent/SI1928820T1/sl unknown
- 2006-08-31 WO PCT/US2006/034370 patent/WO2007030405A2/fr active Application Filing
- 2006-08-31 US US11/514,741 patent/US20070055066A1/en not_active Abandoned
- 2006-08-31 JP JP2008530111A patent/JP2009507842A/ja active Pending
- 2006-08-31 EP EP06802794A patent/EP1934189A2/fr not_active Withdrawn
- 2006-08-31 US US11/515,278 patent/US20070055067A1/en not_active Abandoned
- 2006-08-31 CN CNA2006800410847A patent/CN101300237A/zh active Pending
- 2006-08-31 JP JP2008530125A patent/JP5113754B2/ja not_active Expired - Fee Related
- 2006-08-31 UA UAA200804362A patent/UA93212C2/ru unknown
- 2006-08-31 EP EP06802796A patent/EP1934190A2/fr not_active Withdrawn
- 2006-08-31 JP JP2008530112A patent/JP2009507074A/ja not_active Withdrawn
- 2006-08-31 CN CN2006800411958A patent/CN101300227B/zh active Active
- 2006-08-31 RU RU2008112952/04A patent/RU2008112952A/ru unknown
- 2006-08-31 MX MX2008003188A patent/MX2008003188A/es unknown
- 2006-08-31 TW TW095132200A patent/TW200800924A/zh unknown
- 2006-08-31 CA CA002621987A patent/CA2621987A1/fr not_active Abandoned
- 2006-08-31 RU RU2008112946/04A patent/RU2008112946A/ru not_active Application Discontinuation
- 2006-08-31 BR BRPI0615565-0A patent/BRPI0615565A2/pt not_active IP Right Cessation
- 2006-08-31 ES ES06824884.8T patent/ES2459205T3/es active Active
- 2006-08-31 TW TW095132185A patent/TW200804253A/zh unknown
- 2006-08-31 WO PCT/US2006/034219 patent/WO2007030386A2/fr active Application Filing
- 2006-08-31 MX MX2008003186A patent/MX2008003186A/es unknown
- 2006-08-31 KR KR1020087005952A patent/KR20080049039A/ko not_active Withdrawn
- 2006-08-31 TW TW095132192A patent/TWI331139B/zh not_active IP Right Cessation
- 2006-08-31 AU AU2006287716A patent/AU2006287716A1/en not_active Abandoned
- 2006-08-31 US US11/515,135 patent/US7786329B2/en active Active
- 2006-08-31 MX MX2008003187A patent/MX2008003187A/es unknown
- 2006-08-31 AU AU2006287697A patent/AU2006287697A1/en not_active Abandoned
- 2006-08-31 AU AU2006287696A patent/AU2006287696A1/en not_active Abandoned
- 2006-08-31 CA CA002621971A patent/CA2621971A1/fr not_active Abandoned
- 2006-08-31 KR KR1020087005954A patent/KR20080049040A/ko not_active Withdrawn
2008
- 2008-02-28 IL IL189829A patent/IL189829A0/en unknown
- 2008-02-28 IL IL189830A patent/IL189830A0/en unknown
- 2008-02-28 IL IL189828A patent/IL189828A0/en unknown
- 2008-03-04 ZA ZA200802047A patent/ZA200802047B/xx unknown
- 2008-03-04 ZA ZA200802046A patent/ZA200802046B/xx unknown
- 2008-03-04 ZA ZA200802048A patent/ZA200802048B/xx unknown
- 2008-03-13 EC EC2008008266A patent/ECSP088266A/es unknown
- 2008-03-13 EC EC2008008268A patent/ECSP088268A/es unknown
- 2008-03-13 EC EC2008008267A patent/ECSP088267A/es unknown
- 2008-04-04 NO NO20081684A patent/NO20081684L/no not_active Application Discontinuation
- 2008-04-04 NO NO20081685A patent/NO20081685L/no not_active Application Discontinuation
- 2008-04-04 NO NO20081686A patent/NO20081686L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
UA93212C2 (ru)	2011-01-25
KR20080041699A (ko)	2008-05-13
ECSP088266A (es)	2008-04-28
EP1934190A2 (fr)	2008-06-25
JP2009507842A (ja)	2009-02-26
ECSP088268A (es)	2008-04-28
WO2007030405A3 (fr)	2007-05-18
ES2459205T3 (es)	2014-05-08
TW200804253A (en)	2008-01-16
KR20080049039A (ko)	2008-06-03
NO20081685L (no)	2008-06-05
AU2006287697A1 (en)	2007-03-15
JP2009507075A (ja)	2009-02-19
CN101300237A (zh)	2008-11-05
BRPI0615764A2 (pt)	2011-05-24
US20070055066A1 (en)	2007-03-08
TWI331139B (en)	2010-10-01
ECSP088267A (es)	2008-04-28
EP1928820B1 (fr)	2014-01-29
TW200800924A (en)	2008-01-01
US20070055080A1 (en)	2007-03-08
AU2006287716A1 (en)	2007-03-15
RU2008112952A (ru)	2009-10-20
WO2007030386A3 (fr)	2007-05-24
SI1928820T1 (sl)	2014-08-29
WO2007030405A2 (fr)	2007-03-15
BRPI0615767A2 (pt)	2011-05-24
CA2621961A1 (fr)	2007-03-15
MX2008003187A (es)	2008-03-18
WO2007030386A2 (fr)	2007-03-15
WO2007030385A3 (fr)	2007-05-24
CN101300227B (zh)	2013-07-03
KR101408596B1 (ko)	2014-06-17
JP5113754B2 (ja)	2013-01-09
MX2008003188A (es)	2008-03-18
IL189830A0 (en)	2008-11-03
RU2008112950A (ru)	2009-10-20
EP1928820A2 (fr)	2008-06-11
US20070055067A1 (en)	2007-03-08
ZA200802046B (en)	2008-12-31
IL189828A0 (en)	2008-11-03
WO2007030385A2 (fr)	2007-03-15
EP1934189A2 (fr)	2008-06-25
KR20080049040A (ko)	2008-06-03
CA2621987A1 (fr)	2007-03-15
AU2006287696A1 (en)	2007-03-15
ZA200802047B (en)	2008-12-31
JP2009507074A (ja)	2009-02-19
CN101300227A (zh)	2008-11-05
TW200804254A (en)	2008-01-16
BRPI0615565A2 (pt)	2011-05-24
NO20081686L (no)	2008-06-05
CA2621971A1 (fr)	2007-03-15
US7786329B2 (en)	2010-08-31
RU2008112946A (ru)	2009-10-20
MX2008003186A (es)	2008-03-18
IL189829A0 (en)	2008-11-03
CN101300238A (zh)	2008-11-05
ZA200802048B (en)	2008-11-26

Legal Events

Date	Code	Title	Description
2012-03-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20081684L (no)	2008-06-05	En forbedret fremgangsmate for fremstilling av okazolidin-beskyttende aminodiolforbindelser anvendbare som mellomprodukter for Florfenicol
EA200970605A1 (ru)	2009-12-30	Ингибиторы mapk/erk-киназ
UY33981A (es)	2013-10-31	?método para preparar compuestos macrocíclicos inhibidores de serina proteasas de hepatitis c?.
NO20074093L (no)	2008-02-07	Fremgangsmater for fremstilling av glukopyranosyl-substituerte benzyl-benzenderivater og mellomprodukter derav
UY32049A (es)	2010-03-26	Inhibidores de cmet
MX337588B (es)	2016-03-11	Metodo para preparar derivados de 5-haloalquil-4,5-dihidroisoxasol .
CL2008001562A1 (es)	2008-12-05	Proceso para la preparacion de compuestos de aminodiol protegidos con oxazolina; los compuestos intermediarios considerados; utiles como intermediarios en la preparacion de florfenicol.
BRPI0615705A2 (pt)	2016-08-23	processo para preparar um composto, e, composto
EA200800321A1 (ru)	2008-06-30	Ингибиторы гистондеацетилазы
WO2010014566A3 (fr)	2010-05-20	Procédé de préparation de composés aminodiol d'oxazoline protégés utiles comme produits intermédiaires dans la production de florfénicol
NO20082263L (no)	2008-07-07	Organiske forbindelser
CL2008003095A1 (es)	2010-01-22	Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.
BRPI0713314A2 (pt)	2012-03-06	Processo para a preparação de 3-(2-hidróxi-5-fenil substituído)-n-alquil-3-fenilpropilaminas
PA8804601A1 (es)	2009-06-23	5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas, un proceso para su producción y su uso como agentes antiinflamatorios.
NO20081621L (no)	2008-05-06	Tetrahydrokinoliner, syntese og intermediater
CR11824A (es)	2011-01-12	Derivados heterocíclicos de la urea y sus métodos de empleo
EA200870038A1 (ru)	2008-10-30	Способ получения аминов
EA200801893A1 (ru)	2009-04-28	Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления
TNSN06260A1 (en)	2007-12-03	Process for the preparation of tryptase inhibitors
EA200701852A1 (ru)	2008-04-28	Производные аминокислот
CL2008002174A1 (es)	2008-11-21	Proceso para preparar aminodioles de oxazolidina y oxazolidina; uno de los aminodioles protegidos que se obtiene; y uno de los compuestos intermediarios que se forma en los procesos descritos
CL2008002058A1 (es)	2008-11-14	Metodo para la preparacion de trifluoralquil-fenil-sulfonamidas y de sulfonamidas heterociclicas usando n-trifluoroacteilmorfolina; su metodo de preparacion y su uso.
EA200800200A1 (ru)	2008-06-30	Способ получения кристаллического периндоприла
UY28754A1 (es)	2005-09-30	Proceso quimico
EA200700550A1 (ru)	2007-10-26	Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств