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NO20030844L - Fremgangsmåte for fremstilling av N-aryl-antranilinsyrer og derivater derav - Google Patents

Fremgangsmåte for fremstilling av N-aryl-antranilinsyrer og derivater derav

Info

Publication number
NO20030844L
NO20030844L NO20030844A NO20030844A NO20030844L NO 20030844 L NO20030844 L NO 20030844L NO 20030844 A NO20030844 A NO 20030844A NO 20030844 A NO20030844 A NO 20030844A NO 20030844 L NO20030844 L NO 20030844L
Authority
NO
Norway
Prior art keywords
aryl
derivatives
preparation
anthranilic acids
anthranilic
Prior art date
Application number
NO20030844A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030844D0 (no
Inventor
Michael Huai Gu Chen
Javier Magano
Edward Mark Davis
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20030844D0 publication Critical patent/NO20030844D0/no
Publication of NO20030844L publication Critical patent/NO20030844L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
NO20030844A 2000-08-25 2003-02-24 Fremgangsmåte for fremstilling av N-aryl-antranilinsyrer og derivater derav NO20030844L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (fr) 2000-08-25 2001-07-20 Procede de fabrication d'acides n-aryle-anthraniliques et de leurs derives

Publications (2)

Publication Number Publication Date
NO20030844D0 NO20030844D0 (no) 2003-02-24
NO20030844L true NO20030844L (no) 2003-02-25

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030844A NO20030844L (no) 2000-08-25 2003-02-24 Fremgangsmåte for fremstilling av N-aryl-antranilinsyrer og derivater derav

Country Status (31)

Country Link
EP (1) EP1313694A1 (fr)
JP (1) JP2004507518A (fr)
KR (1) KR20030059115A (fr)
CN (1) CN1458921A (fr)
AP (1) AP2001002249A0 (fr)
AR (1) AR032175A1 (fr)
AU (1) AU2001277044A1 (fr)
BG (1) BG107635A (fr)
BR (1) BR0113520A (fr)
CA (1) CA2420003A1 (fr)
CZ (1) CZ2003477A3 (fr)
DO (1) DOP2001000238A (fr)
EA (1) EA200300187A1 (fr)
GT (1) GT200100174A (fr)
HN (1) HN2001000216A (fr)
HU (1) HUP0300828A2 (fr)
IL (1) IL154507A0 (fr)
IS (1) IS6724A (fr)
MA (1) MA26949A1 (fr)
MX (1) MXPA03001654A (fr)
NO (1) NO20030844L (fr)
PA (1) PA8526501A1 (fr)
PE (1) PE20020393A1 (fr)
PL (1) PL360699A1 (fr)
SK (1) SK2072003A3 (fr)
SV (1) SV2002000601A (fr)
TN (1) TNSN01127A1 (fr)
UY (1) UY26908A1 (fr)
WO (1) WO2002018319A1 (fr)
YU (1) YU14303A (fr)
ZA (1) ZA200301182B (fr)

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US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PT2130537E (pt) 2002-03-13 2012-12-20 Array Biopharma Inc Derivados de benzimidazole n3 alquilado como inibidores de mek
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
CA2542210A1 (fr) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Forme polymorphe du n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-fluoro-4-iodophenylamino)-benzamide
PL1689233T3 (pl) 2003-11-19 2012-11-30 Array Biopharma Inc Bicykliczne inhibitory MEK
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
CN102786482A (zh) 2003-11-21 2012-11-21 阿雷生物药品公司 Akt蛋白激酶抑制剂
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
DK2332909T3 (da) 2005-04-13 2014-11-10 Astex Therapeutics Ltd Hydroxybenzamidderivater og deres anvendelse som inhibitorer af hsp90
ES2405785T3 (es) 2005-05-18 2013-06-03 Array Biopharma Inc. Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101631778B (zh) 2006-07-06 2013-05-08 阵列生物制药公司 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶
US9303040B2 (en) 2006-07-06 2016-04-05 Array Biopharma Inc. Substituted piperazines as AKT inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
EP2073802A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
JP5410285B2 (ja) 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド 医薬化合物
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
KR101650956B1 (ko) 2007-07-05 2016-08-24 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
KR101624361B1 (ko) 2007-07-05 2016-05-25 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
AU2009204019B2 (en) 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
ES2422733T3 (es) 2008-01-09 2013-09-13 Array Biopharma Inc Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
US20120316337A1 (en) * 2010-02-19 2012-12-13 Universite Du Maine Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group
CA2789373A1 (fr) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Processus de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques soutenant au moins un groupe attirant les electrons
CA2844699C (fr) 2011-04-01 2019-05-07 Genentech, Inc. Combinaisons de composes inhibiteurs d'akt et d'abiraterone et procedes d'utilisation
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
WO2014059422A1 (fr) * 2012-10-12 2014-04-17 Exelixis, Inc. Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (fr) * 1997-02-28 1998-09-03 Warner Lambert Company Methode de traitement ou de prevention du choc septique par administration d'un inhibiteur mek
ES2274572T3 (es) * 1997-07-01 2007-05-16 Warner-Lambert Company Llc Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek.
CA2290506C (fr) * 1997-07-01 2005-12-27 Warner-Lambert Company Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek
CA2348236A1 (fr) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, et 4-arylthio diarylamines et leurs derives comme inhibiteurs selectifs de mek
EP1171418B1 (fr) * 1999-04-21 2004-12-29 Warner-Lambert Company LLC Procede de preparation d'acides 2-(n-phenylalmino)benzoiques

Also Published As

Publication number Publication date
PA8526501A1 (es) 2002-07-30
IS6724A (is) 2003-02-20
KR20030059115A (ko) 2003-07-07
YU14303A (sh) 2006-08-17
IL154507A0 (en) 2003-09-17
PE20020393A1 (es) 2002-05-09
EP1313694A1 (fr) 2003-05-28
BG107635A (bg) 2004-09-30
NO20030844D0 (no) 2003-02-24
UY26908A1 (es) 2001-11-30
GT200100174A (es) 2002-07-18
CA2420003A1 (fr) 2002-03-07
MA26949A1 (fr) 2004-12-20
AP2001002249A0 (en) 2001-09-30
ZA200301182B (en) 2004-05-12
AU2001277044A1 (en) 2002-03-13
CZ2003477A3 (cs) 2003-10-15
PL360699A1 (en) 2004-09-20
SV2002000601A (es) 2002-04-03
AR032175A1 (es) 2003-10-29
TNSN01127A1 (en) 2005-11-10
DOP2001000238A (es) 2003-01-31
JP2004507518A (ja) 2004-03-11
HN2001000216A (es) 2002-05-22
HUP0300828A2 (hu) 2003-09-29
CN1458921A (zh) 2003-11-26
EA200300187A1 (ru) 2003-08-28
BR0113520A (pt) 2003-06-24
MXPA03001654A (es) 2004-09-10
SK2072003A3 (en) 2004-01-08
WO2002018319A1 (fr) 2002-03-07

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