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MX2007009664A - Inhibidores de proteasoma y metodos para usar los mismos. - Google Patents

Inhibidores de proteasoma y metodos para usar los mismos.

Info

Publication number
MX2007009664A
MX2007009664A MX2007009664A MX2007009664A MX2007009664A MX 2007009664 A MX2007009664 A MX 2007009664A MX 2007009664 A MX2007009664 A MX 2007009664A MX 2007009664 A MX2007009664 A MX 2007009664A MX 2007009664 A MX2007009664 A MX 2007009664A
Authority
MX
Mexico
Prior art keywords
methods
same
proteasome inhibitors
compositions
proteasome activity
Prior art date
Application number
MX2007009664A
Other languages
English (en)
Inventor
Ambrogio Oliva
Raffaella Bernardnini
Germano D Arasmo
Paolo G Cassara
Alberto Bernareggi
Ernesto Menta
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of MX2007009664A publication Critical patent/MX2007009664A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invencion proporciona compuestos de acido boronico, esteres boronicos y composiciones de los mismos, que pueden modular la apoptosis, tal como mediante inhibicion de actividad de proteasoma. Los compuestos y composiciones pueden usarse en los metodos para inducir apoptosis y tratar enfermedades, tales como, cancer y otros desordenes asociados directa o indirectamente con la actividad de proteasoma.
MX2007009664A 2005-02-11 2006-02-10 Inhibidores de proteasoma y metodos para usar los mismos. MX2007009664A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65237005P 2005-02-11 2005-02-11
US11/351,193 US7468383B2 (en) 2005-02-11 2006-02-09 Proteasome inhibitors and methods of using the same
PCT/US2006/004664 WO2006086600A1 (en) 2005-02-11 2006-02-10 Proteasome inhibitors and methods of using the same

Publications (1)

Publication Number Publication Date
MX2007009664A true MX2007009664A (es) 2007-09-26

Family

ID=36579482

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007009664A MX2007009664A (es) 2005-02-11 2006-02-10 Inhibidores de proteasoma y metodos para usar los mismos.

Country Status (19)

Country Link
US (2) US7468383B2 (es)
EP (1) EP1846424B1 (es)
JP (1) JP2008530108A (es)
AT (1) ATE456571T1 (es)
AU (1) AU2006213814B2 (es)
CA (1) CA2597273C (es)
CY (1) CY1109985T1 (es)
DE (1) DE602006012013D1 (es)
DK (1) DK1846424T3 (es)
ES (1) ES2339698T3 (es)
IL (1) IL184678A (es)
MX (1) MX2007009664A (es)
MY (1) MY147921A (es)
NZ (1) NZ560607A (es)
PL (1) PL1846424T3 (es)
PT (1) PT1846424E (es)
SI (1) SI1846424T1 (es)
TW (1) TWI367886B (es)
WO (1) WO2006086600A1 (es)

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CN105837608B (zh) * 2007-08-06 2018-06-08 米伦纽姆医药公司 蛋白酶体抑制剂及其组合物和用途
US20110118274A1 (en) * 2007-08-23 2011-05-19 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
AU2008307510A1 (en) 2007-10-04 2009-04-09 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
JP5600595B2 (ja) * 2007-10-16 2014-10-01 ミレニアム ファーマシューティカルズ， インコーポレイテッド プロテアソーム阻害剤
EP2088205A1 (en) 2008-02-11 2009-08-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) PSMB10: A diagnosis marker and therapeutic target of chronic rejection.
MX340186B (es) 2008-06-17 2016-06-29 Millennium Pharm Inc Compuestos de ester boronato y composiciones farmaceuticas de los mismos.
AU2009279787B2 (en) * 2008-08-04 2014-05-29 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
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TR201810411T4 (tr) 2014-04-08 2018-08-27 Neurovive Pharmaceutical Ab Özgün hücre geçirgen süksinat bileşikleri.
CN106659761A (zh) 2014-05-20 2017-05-10 千年药物公司 初级癌症疗法后使用的含硼蛋白酶体抑制剂
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CN113061144A (zh) * 2017-02-28 2021-07-02 正大天晴药业集团股份有限公司 氮杂环丁烷衍生物
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Also Published As

Publication number Publication date
DK1846424T3 (da) 2010-05-17
DE602006012013D1 (de) 2010-03-18
CA2597273C (en) 2013-12-17
AU2006213814B2 (en) 2011-10-13
TW200640936A (en) 2006-12-01
CA2597273A1 (en) 2006-08-17
HK1106534A1 (en) 2008-03-14
JP2008530108A (ja) 2008-08-07
ATE456571T1 (de) 2010-02-15
US20090075936A1 (en) 2009-03-19
IL184678A (en) 2012-05-31
MY147921A (en) 2013-02-15
PL1846424T3 (pl) 2010-06-30
SI1846424T1 (sl) 2010-05-31
IL184678A0 (en) 2007-12-03
ES2339698T3 (es) 2010-05-24
US20060189806A1 (en) 2006-08-24
PT1846424E (pt) 2010-04-15
EP1846424B1 (en) 2010-01-27
EP1846424A1 (en) 2007-10-24
TWI367886B (en) 2012-07-11
US7468383B2 (en) 2008-12-23
WO2006086600A1 (en) 2006-08-17
US8283367B2 (en) 2012-10-09
AU2006213814A1 (en) 2006-08-17
CY1109985T1 (el) 2014-09-10
NZ560607A (en) 2009-11-27

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