MEP36508A - Triazolopyrazine derivatives useful as anti-cancer agents - Google Patents

Triazolopyrazine derivatives useful as anti-cancer agents

Info

Publication number: MEP36508A
Authority: ME; Montenegro
Prior art keywords: cancer agents; derivatives useful; triazolopyrazine derivatives; compounds; formula
Prior art date: 2006-05-11

Application number

MEP-365/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Hengmiao Cheng

Jingrong Jean Cui

Jacqui Elizabeth Hoffman

Lei Jia

Mary Catherine Johnson

Robert Steven Kania

Phuong Thi Quy Le

Mitchell David Nambu

Mason Alan Pairish

Hong Shen

Michelle Bich Tran-Dube

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-11

Filing date

2007-04-30

Publication date

2011-02-10

2007-04-30 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2011-02-10 Publication of MEP36508A publication Critical patent/MEP36508A/xx

Links

CJGGKSPGRJHZNP-UHFFFAOYSA-N 2h-triazolo[4,5-b]pyrazine Chemical class C1=CN=C2NN=NC2=N1 CJGGKSPGRJHZNP-UHFFFAOYSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 1
230000003463 hyperproliferative effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MEP-365/08A 2006-05-11 2007-04-30 Triazolopyrazine derivatives useful as anti-cancer agents MEP36508A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US79996606P	2006-05-11	2006-05-11
US89323107P	2007-03-06	2007-03-06
PCT/IB2007/001142 WO2007132308A1 (en)	2006-05-11	2007-04-30	Triazolopyrazine derivatives useful as anti-cancer agents

Publications (1)

Publication Number	Publication Date
MEP36508A true MEP36508A (en)	2011-02-10

Family

ID=38441445

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-365/08A MEP36508A (en)	2006-05-11	2007-04-30	Triazolopyrazine derivatives useful as anti-cancer agents

Country Status (32)

Country	Link
US (2)	US7732604B2 (xx)
EP (1)	EP2018383B1 (xx)
JP (1)	JP4377962B2 (xx)
KR (1)	KR101099161B1 (xx)
CN (1)	CN101443331A (xx)
AP (1)	AP2008004674A0 (xx)
AR (1)	AR060994A1 (xx)
AT (1)	ATE532785T1 (xx)
AU (1)	AU2007251283A1 (xx)
BR (1)	BRPI0711809A2 (xx)
CA (1)	CA2651363C (xx)
CR (1)	CR10383A (xx)
EA (1)	EA016204B1 (xx)
EC (1)	ECSP088871A (xx)
ES (1)	ES2376913T3 (xx)
GE (1)	GEP20115174B (xx)
GT (1)	GT200700039A (xx)
HN (1)	HN2007015177A (xx)
IL (1)	IL194813A0 (xx)
MA (1)	MA30411B1 (xx)
ME (1)	MEP36508A (xx)
MX (1)	MX2008014399A (xx)
NL (1)	NL2000613C2 (xx)
NO (1)	NO20085060L (xx)
NZ (1)	NZ572361A (xx)
PE (1)	PE20080067A1 (xx)
RS (1)	RS20080533A (xx)
TN (1)	TNSN08445A1 (xx)
TW (1)	TWI346115B (xx)
UY (1)	UY30334A1 (xx)
WO (1)	WO2007132308A1 (xx)
ZA (1)	ZA200809020B (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20121506A1 (es)	2006-07-14	2012-11-26	Amgen Inc	Compuestos triazolopiridinas como inhibidores de c-met
US8217177B2 (en)	2006-07-14	2012-07-10	Amgen Inc.	Fused heterocyclic derivatives and methods of use
US8198448B2 (en) *	2006-07-14	2012-06-12	Amgen Inc.	Fused heterocyclic derivatives and methods of use
DE102007026341A1 (de)	2007-06-06	2008-12-11	Merck Patent Gmbh	Benzoxazolonderivate
DE102007032507A1 (de)	2007-07-12	2009-04-02	Merck Patent Gmbh	Pyridazinonderivate
US20110039856A1 (en) *	2007-11-29	2011-02-17	Pfizer Inc.	Polymorphs of a c-met/hgfr inhibitor
DE102007061963A1 (de)	2007-12-21	2009-06-25	Merck Patent Gmbh	Pyridazinonderivate
US20110009421A1 (en) *	2008-02-27	2011-01-13	Takeda Pharmaceutical Company Limited	Compound having 6-membered aromatic ring
CA2717034A1 (en) *	2008-02-28	2009-09-03	Pascal Furet	Imidazo[1,2-b]pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
JP2011515343A (ja) *	2008-03-03	2011-05-19	タイガーファーマテック	チロシンキナーゼ阻害薬
DE102008019907A1 (de)	2008-04-21	2009-10-22	Merck Patent Gmbh	Pyridazinonderivate
DE102008028905A1 (de)	2008-06-18	2009-12-24	Merck Patent Gmbh	3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
EP2298731A4 (en) *	2008-06-25	2011-09-21	Takeda Pharmaceutical	AMIDE COMPOUND
DE102008037790A1 (de)	2008-08-14	2010-02-18	Merck Patent Gmbh	Bicyclische Triazolderivate
EP2356116A1 (en)	2008-11-20	2011-08-17	OSI Pharmaceuticals, Inc.	Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
EP2381777A4 (en) *	2008-12-12	2012-08-08	Ariad Pharma Inc	AZAINDOL DERIVATIVES AS KINASEHEMMER
EA019320B1 (ru)	2008-12-22	2014-02-28	Мерк Патент Гмбх	Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения
JOP20190230A1 (ar)	2009-01-15	2017-06-16	Incyte Corp	طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
WO2010138665A1 (en) *	2009-05-28	2010-12-02	Vertex Pharmaceuticals Incorporated	Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
KR20120089643A (ko) *	2009-08-12	2012-08-13	노파르티스 아게	헤테로시클릭 히드라존 화합물, 및 암 및 염증을 치료하기 위한 그의 용도
JP5775871B2 (ja) *	2009-08-20	2015-09-09	ノバルティスアーゲー	ヘテロ環式オキシム化合物
DE102009056886A1 (de)	2009-12-03	2011-06-09	Bayer Schering Pharma Aktiengesellschaft	cMet-Inhibitoren zur Behandlung der Endometriose
LT3795573T (lt) *	2009-12-31	2022-11-10	Hutchison Medipharma Limited	Tam tikri triazolopirazinai, jų sudėtis ir jų panaudojimo būdai
TWI423974B (zh) *	2010-02-11	2014-01-21	Hutchison Medipharma Ltd	三氮唑並吡啶和三氮唑並吡嗪化合物及其組合物和應用
US20130072495A1 (en)	2010-05-14	2013-03-21	OSI Pharmaceuticals, LLC	Fused bicyclic kinase inhibitors
AR081039A1 (es)	2010-05-14	2012-05-30	Osi Pharmaceuticals Llc	Inhibidores biciclicos fusionados de quinasa
EP2571878B1 (en) *	2010-05-17	2018-10-17	Incozen Therapeutics Pvt. Ltd.	Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases
JP2013532627A (ja)	2010-07-01	2013-08-19	武田薬品工業株式会社	ｃＭＥＴ阻害剤とＨＧＦおよび／またはｃＭＥＴに対する抗体との組み合わせ
WO2012042421A1 (en)	2010-09-29	2012-04-05	Pfizer Inc.	Method of treating abnormal cell growth
CN102532141A (zh)	2010-12-08	2012-07-04	中国科学院上海药物研究所	[1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
EP2710003A1 (en)	2011-05-16	2014-03-26	OSI Pharmaceuticals, LLC	Fused bicyclic kinase inhibitors
KR20140077916A (ko)	2011-09-15	2014-06-24	노파르티스 아게	티로신 키나제로서의 6-치환된 3-(퀴놀린-6-일티오)-[1,2,4]트리아졸로[4,3-a]피라딘
CN102516263B (zh) *	2011-10-25	2015-04-08	南方医科大学	一种螺三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
CN102503959B (zh) *	2011-10-25	2015-04-08	南方医科大学	一种稠三环类化合物及其制备方法、以及含该类化合物的药物组合物及其应用
CN103204844A (zh) *	2012-01-17	2013-07-17	上海艾力斯医药科技有限公司	氨基杂芳基化合物及其制备方法与应用
US9815831B2 (en)	2012-03-30	2017-11-14	Rhizen Pharmaceuticals Sa	3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of c-Met protein kinases
KR20140146086A (ko)	2012-04-03	2014-12-24	노파르티스 아게	티로신 키나제 억제제 조합물 및 그의 용도
KR102115047B1 (ko)	2012-04-03	2020-05-26	노파르티스 아게	티로신 키나제 억제제들을 갖는 조합 제품 및 그의 용도
CN105968115B (zh) *	2013-04-17	2018-11-09	上海医药集团股份有限公司	喹啉类化合物、其制备方法、中间体、药物组合物和应用
WO2014174478A1 (en)	2013-04-26	2014-10-30	Novartis Ag	Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
EP3053923B1 (en) *	2013-09-30	2018-04-11	Korea Research Institute of Chemical Technology	Triazolopyrazine derivatives as tyrosin kinase inhibitors
WO2016091891A1 (en)	2014-12-09	2016-06-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Human monoclonal antibodies against axl
WO2016135041A1 (en)	2015-02-26	2016-09-01	INSERM (Institut National de la Santé et de la Recherche Médicale)	Fusion proteins and antibodies comprising thereof for promoting apoptosis
JP2018123059A (ja) *	2015-06-10	2018-08-09	石原産業株式会社	１−シクロプロピルエチルアミン又はその塩の製造方法
KR102665765B1 (ko) *	2015-07-20	2024-05-10	젠자임 코포레이션	콜로니 자극 인자-1 수용체(csf-1r) 저해제
WO2017049711A1 (zh)	2015-09-24	2017-03-30	上海海聚生物科技有限公司	喹啉类衍生物、其药物组合物、制备方法及应用
CN109369656B (zh) *	2015-12-31	2021-05-07	上海医药集团股份有限公司	喹啉类化合物硫酸盐的晶型、制备方法、组合物与应用
KR102511024B1 (ko)	2016-03-15	2023-03-16	오리존 지노믹스 에스.에이.	고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물
IL263429B (en)	2016-06-20	2022-08-01	Novartis Ag	Crystalline forms of triazolopyrimidine compound
KR20180092096A (ko) *	2017-02-08	2018-08-17	에이비온 주식회사	트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법
CN108570053A (zh) *	2017-03-13	2018-09-25	中国科学院上海药物研究所	五元并六元杂环化合物、制备方法、中间体、组合和应用
CN108276418A (zh) *	2018-03-20	2018-07-13	北京凯恩梅格医药科技有限公司	化合物、含有该化合物的药用组合物及其用途
SG11202105872RA (en) *	2018-12-14	2021-07-29	Beta Pharma Inc	Organophosphorus-substituted compounds as c-met inhibitors and therapeutic uses thereof
JP2024500919A (ja)	2020-12-23	2024-01-10	ジェンザイム・コーポレーション	重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587458A (en)	1991-10-07	1996-12-24	Aronex Pharmaceuticals, Inc.	Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
EP1514934B1 (en)	1992-02-06	2008-12-31	Novartis Vaccines and Diagnostics, Inc.	Biosynthetic binding protein for cancer marker
IL112248A0 (en)	1994-01-25	1995-03-30	Warner Lambert Co	Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
GB9520822D0 (en)	1995-10-11	1995-12-13	Wellcome Found	Therapeutically active compounds
JP2000515136A (ja)	1996-07-13	2000-11-14	グラクソ、グループ、リミテッド	プロテインチロシンキナーゼ阻害剤としての二環式ヘテロ芳香族化合物
ES2186908T3 (es)	1996-07-13	2003-05-16	Glaxo Group Ltd	Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas.
RS49779B (sr)	1998-01-12	2008-06-05	Glaxo Group Limited,	Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
GB9800575D0 (en)	1998-01-12	1998-03-11	Glaxo Group Ltd	Heterocyclic compounds
SK3812002A3 (en) *	1999-09-17	2003-09-11	Abbott Gmbh & Co Kg	Pyrazolopyrimidines as therapeutic agents
EP1643836A4 (en) *	2003-07-02	2006-12-06	Sugen Inc	ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINE C-MET INHIBITORS
EP1675858A2 (en)	2003-09-03	2006-07-05	Neurogen Corporation	5-aryl-pyrazolo [4,3-d] pyrimidines, pyridines, and pyrazines and related compounds
US20130246300A1 (en)	2012-03-13	2013-09-19	American Express Travel Related Services Company, Inc.	Systems and Methods for Tailoring Marketing
US10884952B2 (en)	2016-09-30	2021-01-05	Intel Corporation	Enforcing memory operand types using protection keys

2007
- 2007-04-26 NL NL2000613A patent/NL2000613C2/nl not_active IP Right Cessation
- 2007-04-30 BR BRPI0711809-0A patent/BRPI0711809A2/pt not_active IP Right Cessation
- 2007-04-30 JP JP2009508530A patent/JP4377962B2/ja not_active Expired - Fee Related
- 2007-04-30 EP EP07734459A patent/EP2018383B1/en active Active
- 2007-04-30 WO PCT/IB2007/001142 patent/WO2007132308A1/en active Application Filing
- 2007-04-30 AP AP2008004674A patent/AP2008004674A0/xx unknown
- 2007-04-30 CN CNA2007800170852A patent/CN101443331A/zh active Pending
- 2007-04-30 ME MEP-365/08A patent/MEP36508A/xx unknown
- 2007-04-30 ES ES07734459T patent/ES2376913T3/es active Active
- 2007-04-30 RS RSP-2008/0533A patent/RS20080533A/sr unknown
- 2007-04-30 CA CA2651363A patent/CA2651363C/en not_active Expired - Fee Related
- 2007-04-30 AU AU2007251283A patent/AU2007251283A1/en not_active Abandoned
- 2007-04-30 MX MX2008014399A patent/MX2008014399A/es active IP Right Grant
- 2007-04-30 NZ NZ572361A patent/NZ572361A/en not_active IP Right Cessation
- 2007-04-30 GE GEAP200710971A patent/GEP20115174B/en unknown
- 2007-04-30 KR KR1020087027474A patent/KR101099161B1/ko not_active Expired - Fee Related
- 2007-04-30 EA EA200870423A patent/EA016204B1/ru not_active IP Right Cessation
- 2007-04-30 AT AT07734459T patent/ATE532785T1/de active
- 2007-05-08 US US11/745,921 patent/US7732604B2/en not_active Expired - Fee Related
- 2007-05-09 AR ARP070102012A patent/AR060994A1/es not_active Application Discontinuation
- 2007-05-09 PE PE2007000559A patent/PE20080067A1/es not_active Application Discontinuation
- 2007-05-09 UY UY30334A patent/UY30334A1/es unknown
- 2007-05-09 HN HN2007015177A patent/HN2007015177A/es unknown
- 2007-05-09 GT GT200700039A patent/GT200700039A/es unknown
- 2007-05-10 TW TW096116645A patent/TWI346115B/zh not_active IP Right Cessation
2008
- 2008-10-21 ZA ZA2008/09020A patent/ZA200809020B/en unknown
- 2008-10-21 CR CR10383A patent/CR10383A/es not_active Application Discontinuation
- 2008-10-22 IL IL194813A patent/IL194813A0/en unknown
- 2008-11-06 TN TNP2008000445A patent/TNSN08445A1/fr unknown
- 2008-11-07 EC EC2008008871A patent/ECSP088871A/es unknown
- 2008-11-11 MA MA31378A patent/MA30411B1/fr unknown
- 2008-12-03 NO NO20085060A patent/NO20085060L/no not_active Application Discontinuation
2010
- 2010-01-04 US US12/651,984 patent/US20100105656A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP4377962B2 (ja)	2009-12-02
TWI346115B (en)	2011-08-01
EP2018383A1 (en)	2009-01-28
CN101443331A (zh)	2009-05-27
US7732604B2 (en)	2010-06-08
KR101099161B1 (ko)	2011-12-27
MX2008014399A (es)	2008-11-27
NO20085060L (no)	2008-12-03
US20100105656A1 (en)	2010-04-29
WO2007132308A1 (en)	2007-11-22
HN2007015177A (es)	2010-06-09
JP2009536636A (ja)	2009-10-15
CR10383A (es)	2008-11-11
CA2651363C (en)	2011-07-12
ECSP088871A (es)	2008-12-30
GT200700039A (es)	2008-06-02
US20070265272A1 (en)	2007-11-15
TNSN08445A1 (fr)	2010-04-14
AR060994A1 (es)	2008-07-30
ES2376913T3 (es)	2012-03-20
CA2651363A1 (en)	2007-11-22
NZ572361A (en)	2012-02-24
GEP20115174B (en)	2011-03-10
AU2007251283A1 (en)	2007-11-22
UY30334A1 (es)	2008-01-02
PE20080067A1 (es)	2008-03-10
ATE532785T1 (de)	2011-11-15
AP2008004674A0 (en)	2008-12-31
RS20080533A (xx)	2009-09-08
NL2000613C2 (nl)	2007-11-20
TW200804384A (en)	2008-01-16
EA016204B1 (ru)	2012-03-30
MA30411B1 (fr)	2009-05-04
ZA200809020B (en)	2009-12-30
BRPI0711809A2 (pt)	2011-12-06
IL194813A0 (en)	2009-08-03
KR20090006187A (ko)	2009-01-14
EA200870423A1 (ru)	2009-04-28
EP2018383B1 (en)	2011-11-09

Publication	Publication Date	Title
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