Chan et al., 2011 - Google Patents
Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritisChan et al., 2011
View HTML- Document ID
- 16602302381584826803
- Author
- Chan B
- Fuller E
- Russell A
- Smith S
- Smith M
- Jackson M
- Cake M
- Read R
- Bateman J
- Sambrook P
- Little C
- Publication year
- Publication venue
- Osteoarthritis and Cartilage
External Links
Snippet
Objectives To investigate the regulation of sclerostin (SOST) in osteoarthritis (OA) and its potential effects on articular cartilage degradation. Methods SOST and other Wnt-β-catenin components were immuno-localised in osteochondral sections of surgically-induced OA in …
- 108050006698 Sclerostin 0 title abstract description 152
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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