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Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein
Liquid-liquid phase transitions govern a wide range of protein-protein and protein-RNA interactions. Although the importance of multivalency and...
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A roadmap for equitable reuse of public microbiome data
Science benefits from rapid open data sharing, but current guidelines for data reuse were established two decades ago, when databases were several...
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Neutrino interaction vertex reconstruction in DUNE with Pandora deep learning
The Pandora Software Development Kit and algorithm libraries perform reconstruction of neutrino interactions in liquid argon time projection chamber...
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Annotation of protein-coding genes in 49 diatom genomes from the Bacillariophyta clade
Diatoms, a major group of microalgae, play a critical role in global carbon cycling and primary production. Despite their ecological significance,...
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Navigating Eukaryotic Genome Annotation Pipelines: A Route Map to Using BRAKER, Galba, and TSEBRA
Annotating the structure of protein-coding genes represents a major challenge in the analysis of eukaryotic genomes. This task sets the groundwork... -
Maximal oxygen uptake, pulmonary function and walking economy are not impaired in patients diagnosed with long COVID
IntroductionSARS-CoV-2 may result in the development of new symptoms, known as long COVID, a few months after the original infection.
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Two novel genomes of fireflies with different degrees of sexual dimorphism reveal insights into sex-biased gene expression and dosage compensation
Sexual dimorphism arises because of divergent fitness optima between the sexes. Phenotypic divergence between sexes can range from mild to extreme....
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Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
BackgroundStreptococcus pyogenes(group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat...
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Galba: genome annotation with miniprot and AUGUSTUS
BackgroundThe Earth Biogenome Project has rapidly increased the number of available eukaryotic genomes, but most released genomes continue to lack...
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Reconstruction of interactions in the ProtoDUNE-SP detector with Pandora
The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle...
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Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
BackgroundStreptococcus pyogenes(group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections...
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Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395
BackgroundKlebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant...
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A geometrical approach to nontrivial topology via exotic spinors
Exotic spinors arise in non-simply connected base manifolds due to the nonequivalent spinor structure. The dynamics of exotic spinors are endowed...
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Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing...
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Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase...
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TSEBRA: transcript selector for BRAKER
BackgroundBRAKER is a suite of automatic pipelines, BRAKER1 and BRAKER2, for the accurate annotation of protein-coding genes in eukaryotic genomes....
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The cumulation of ill health and low agency in socially excluded city dwellers in the Netherlands: how to better identify high-risk/high-need population segments with public health survey data
BackgroundPopulation segmentation and risk stratification are important strategies for allocating resources in public health, health care and social...