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Chronic Anatabine Administration Attenuates Cardiovascular Activity by Targeting NF-κB/NLRP3/Caspase-1-Dependent Pyroptosis and Oxidative Stress in Paraventricular Nucleus of Hypertensive Rat
Hypertension is characterized by chronic inflammation. Anatabine, a natural alkaloid with anti-inflammatory properties, has demonstrated potential in...
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ALKBH5-mediated NPC2 mRNA m6A demethylation promotes resistance to oxaliplatin in colorectal cancer
Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related death. Oxaliplatin, a key platinum-based...
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Independent risk factors and survival prediction in hip refractures patients: insights from a 10-year cohort
IntroductionHip fracture (HF) is one of the leading causes of mortality and disability in older populations. Hip refracture (HRF) is more serious...
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Development and implementation of an etiology-based diagnostic framework for acute abdominal pain in emergency settings
BackgroundDiagnostic checklists have been demonstrated to reduce errors in clinical reasoning. Building on previous validation studies, this research...
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Climatic characteristics and interannual influencing factors of extreme cyclones in the arctic cold season
Extreme cyclones have a significant impact on the weather and climate of the Arctic; however, their trends and influencing factors remain unclear. In...
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A network of velocity-coherent filaments formed by supersonic turbulence in a very-high-velocity H i cloud
The warm neutral medium (WNM) was thought to be subsonically/transonically turbulent, and it lacks a network of intertwined filaments that are...
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The antibody–drug conjugate SHR-A1904 for targeting CLDN18.2 in advanced gastric or gastroesophageal junction cancer: a phase 1 trial
Claudin-18 isoform 2 (CLDN18.2), a tight junction protein expressed in non-malignant gastric epithelium and exposed on tumor cell surface during...
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Differential diagnosis of gallbladder cholesterol polyps and adenomas using contrast-enhanced ultrasound—morphology and perfusion features
PurposeThis study aimed to evaluate the value of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of gallbladder cholesterol polyps...
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Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014–2024)
BackgroundPersistent high-risk human papillomavirus (HR-HPV) infection may increase the risk of malignancies in males, including penile, rectal,...
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Pulses of ocean acidification at the Triassic–Jurassic boundary
Mass extinctions have repeatedly perturbed the history of life, but their causes are often elusive. Ocean acidification has been implicated during...
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CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism
BackgroundFibrogenesis is a common pathological feature of endometriotic lesions and contributes to the development of endometriosis-associated...
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Causal Association Between Genetically Predicted Ankle Spacing Width and Risk of Age-Related Bone Mineral Density
While observational studies suggest associations between ankle spacing width (ASW, defined as the horizontal distance between the medial malleoli...
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Smart self-reconstruction of electrode materials for fully recyclable protonic ceramic fuel cells
Despite their high-energy conversion efficiency that has earned them the label of next-generation energy utilization devices, protonic ceramic fuel...
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Different management methods for tunnel abscess in tunneled cuffed catheters with catheter-related bloodstream infections and central venous stenosis: two case reports
BackgroundTunneled cuffed catheters (TCCs) are critical vascular access tools for hemodialysis patients, but they are associated with complications...
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Multicomponent Polymerization of Diacetylarenes, Dialkynones, and NH4OAc for In situ Construction of Functional Conjugated Poly(triarylpyridine)s
Exploration of new green polymerization strategies for the construction of conjugated polymers is important but challengeable. In this work, a...
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Interaction behavior between coarse-particle pyrite and fine-particle pyrite in flotation
Pyrite is commonly associated with gold deposits and serves as a gold-bearing mineral. The flotation recovery of gold-bearing pyrite generally...
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GPDet: an anchor-free object detector based on dual center-ness and criss-cross balance for unstructured gastroscopic image data
In gastroscopy image diagnosis, the physiological structure of the stomach and peristalsis causes many interference and blurred regions in the...
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EEG dataset from playing Multiplayer Online Battle Arena games in natural settings
Mobile Multiplayer Online Battle Arena (MOBA) games have emerged as one of the most popular gaming genres, yet the underlying neurophysiological...