Fig. 1
From: Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study
The flowchart of the study. x represents gene expression (exposure). y represents breast cancer risk (outcome). g represents genetic variants (instrumental variable). βgx is the effect size of the association between genetic variants and target gene expression (the exposure). βgy is the effect size of the association between genetic variants and breast cancer risk (outcome). βxy is the effect size of the association between target gene expression and breast cancer risk, estimated with βgx/ βgy using SMR. SNP single-nucleotide polymorphism, MR Mendelian randomization, GWAS genome wide association study, SMR summary-based MR, eQTL expression quantitative trait loci