Any caveats when chaining two instances?

I plan to run pacoloco & apt-cacher ng on a vps which has reflector scheduled via crond.

And locally I run a second layer of both on my nas inside docker.

The idea is that I will always have the most optimal and a single connection for my local vms & servers to the nas and the nas downstream request the same from my upstream vps in the cloud.

Will there be any problems with this setup? Does that even make sense?