VIP is a flexible human variant interpretation pipeline for rare disease using state-of-the-art pathogenicity prediction (CAPICE) and template-based interactive reporting to facilitate decision support.

VIP documentation is available at this link https://molgenis.github.io/vip/.

• GNU-based Linux ( e.g. Ubuntu, Windows Subsystem for Linux) with x86_64 architecture
• Bash ≥ 3.2
• Java ≥ 11
• Apptainer (setuid installation)
• 8GB RAM (an estimate, see also the documentation)
• 280GB disk space

curl -sSL https://download.molgeniscloud.org/downloads/vip/install.sh | bash

HPC systems running EasyBuild can install VIP by adapting the /apps paths in the easyconfig files to your local environment.

usage: vip.sh -w <arg> -i <arg> -o <arg>
  -w, --workflow <arg>  workflow to execute. allowed values: cram, fastq, gvcf, vcf
  -i, --input    <arg>  path to sample sheet .tsv
  -o, --output   <arg>  output folder
  -c, --config   <arg>  path to additional nextflow .cfg (optional)
  -p, --profile  <arg>  nextflow configuration profile (optional)
  -r, --resume          resume execution using cached results (default: false)
  -s, --stub            quickly prototype workflow logic using process script stubs
  -h, --help            print this message and exit

To create the documentation pages:

pip install mkdocs mkdocs-mermaid2-plugin
mkdocs serve

VIP is an aggregate work of many works, each covered by their own licence(s). For the purposes of determining what you can do with specific works in VIP, this policy should be read together with the licence(s) of the relevant tools. For the avoidance of doubt, where any other licence grants rights, this policy does not modify or reduce those rights under those licences.