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Mass testing of mutant enzymes involved in photosynthesis

Rubisco is the enzyme responsible for carbon fixation in plants, algae and many bacteria. A screen of a comprehensive library of rubisco variants (each with a different single-amino-acid mutation), expressed in engineered bacteria, identifies several mutations that improve the enzyme’s affinity for carbon dioxide.
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This is a summary of: Prywes, N. et al. A map of the rubisco biochemical landscape. Nature https://doi.org/10.1038/s41586-024-08455-0 (2025).

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doi: https://doi.org/10.1038/d41586-025-00104-4

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