Sequencing articles from across Nature Portfolio

Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring.

A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring.

Evolutionary map of viral proteins used to design vaccine that provides broad immunity — plus, reviewing 25 years of carbon offsetting.

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

MetaGraph compresses vast data archives into a search engine for scientists, opening up new frontiers of biological discovery.

Rapid identification of pathogenic viruses remains a critical challenge. A recent study advances this frontier by demonstrating a fully integrated memristor-based hardware system that accelerates genomic analysis by a factor of 51, while reducing energy consumption to just 0.2% of that required by conventional computational methods.

We developed scEpi²-seq, a single-cell method which jointly profiles DNA methylation and histone modifications from the same DNA molecule. This multi-omic strategy reveals how chromatin context influences the maintenance of DNA methylation and identifies distinct epigenomic signatures across cell types in both cultured and primary tissues.