Health care articles from across Nature Portfolio

A synthetic peptide nanoparticle and microfluidic chip enable sterility testing of cell- and gene-based therapeutics in under 18 hours, bridging a long-standing safety gap for biopharmaceutical products that cannot undergo terminal sterilization and have limited shelf life.

Pollution from wildfire smoke is increasing in the United States. Climate change is projected to exacerbate the problem, leading to 70,000 premature deaths each year by 2050. If no extra measures are taken, wildfire smoke could become one of the country’s worst climate disasters.

We show that clinically accredited genomic newborn screening can be delivered with short turnaround times, detects many more conditions than standard newborn screening, and is both clinically impactful and highly acceptable to families.

Mycetoma is a chronic, deep skin infection that is often characterised by grains. This Review discusses what is known about mycetoma grain formation, with a focus on Madurella mycetomatis, and the need for multi-disciplinary approaches to aid their clinical management and treatment.

Chronic kidney disease is a silent epidemic that is disproportionately affecting low- and middle-income countries. The landmark WHO global kidney health resolution signals urgency, but impact depends on action. Point-of-care diagnostics are essential to bridge the gap between recognition and reality, enabling equitable early detection, prevention and strengthening of health systems.

A new population-based study suggests that sodium–glucose cotransporter-2 (SGLT2) inhibitors — originally developed for glycaemic control — reduce the risk of autoimmune rheumatic diseases.

With a growing number of studies applying generative artificial intelligence (GAI) models for health purposes, reporting standards are being developed to guide authors in this space. We describe the currently available reporting guidelines that apply to GAI models and provide an overview of upcoming reporting standards. Investigators must remain up-to-date with the most applicable tools to guide the comprehensive reporting of their research as we integrate GAI in healthcare.

Cholera remains a global health threat across the African continent. Here, the authors discuss the current issues relating to the control of the disease, and make recommendations for its management across Africa.