Virus structures articles from across Nature Portfolio

The HKU25 clade MERS-related coronaviruses with broad distribution are shown to use ACE2 as a functional receptor, revealing unexpected receptor plasticity and offering new insights into coronavirus evolution, host range and potential zoonotic risk.

Characterization of dipeptidase 1 as a receptor for porcine haemagglutinating encephalomyelitis virus reveals the versatility of embecovirus receptor binding domains and receptor usage.

Researchers use a chimeric approach to reveal the first near-atomic resolution structures the yellow fever virion, showing key differences between vaccine and virulent strains that affect how antibodies recognise and neutralise the virus.

Rodrigues and Queiroz et al. report the discovery of Naiavirus, the largest enveloped virus, isolated from a Brazil biome. With an oval capsid and flexible tail, its giant genome holds many novel genes, underscoring the value of viral isolation studies.

IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

The study reveals how a satellite phage-encoded protein directs the assembly of coat proteins into small capsids.

This study provides insights into how to determine how mimiviruses package and protect their genomes.

This study reveals that a cross-neutralizing antibody targets a conserved site on betacoronavirus spike proteins and confers protection against SARS-CoV-2 infection.

Cell entry mechanisms of the non-enveloped viruses bluetongue and rhesus rotavirus are delineated using structural and molecular biology.

This study provides ultrastructural evidence that the HIV-1 capsid can enter the nucleus of an infected T cell line through the nuclear pore complex and fragments in the nucleoplasm to release the viral genome.