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Showing 1–2 of 2 results
Advanced filters: Author: Zhan-Bo Jia Clear advanced filters

  • Organic semiconductors suffer from low optical damage thresholds, limiting their use in applications. Here the authors bypass this limit by utilizing spectrally tailored gain from stimulated emission to amplify molecular vibrations in organic semiconductors for efficient Raman lasers.

    • Yi Jiang
    • He Lin
    • Wen-Yong Lai
    Research
    Nature Materials
    P: 1-9

  • We report a kind of functional dendrisomes constructed by amphiphilic dendrimers, which enable to enhance cellular uptake by breast cancer stem cells (CSCs), to differentiate breast CSCs by carrying all-trans retinoic acid (ATRA), and to increase anticancer efficacy by carrying ATRA and docetaxel in vitro and in breast cancer-bearing mice. The study further reveals endocytosis mechanism, and uncovers differentiation mechanism by analyzing relevant signal molecules, transcription factors, and cell cycle associated signaling pathway. Hence, the present study offers a novel type of functional dendrisomes for differentiation therapy of breast CSCs, and has a significant clinical implication.

    • Li-Min Mu
    • Lei Liu
    • Wan-Liang Lu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 11, P: 1-16