Nature Search

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

X-ray crystallographic analysis reveals features of the tandem catalytic domains of histone deacetylase 6 (HDAC6), their inhibition by small molecules and functional insights into the enzyme's role in tubulin deacetylation.

Yasuyuki Miyake
Jeremy J Keusch
Patrick Matthias
Research25 Jul 2016
Nature Chemical Biology

Volume: 12, P: 748-754
Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image

Yuka Sawai
Manabu Miyata
Akitaka Tsujikawa
ResearchOpen Access10 Apr 2020
Scientific Reports

Volume: 10, P: 1-6
PI ^* S _iiyama, a deficiency gene of alpha₁-antitrypsin: Evidence for the occurrence in western Japan

Isao Yuasa
Yuji Sugimoto
Kichiro Okada
Research01 Jun 1993
Japanese journal of human genetics

Volume: 38, P: 185-191
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor dependent anti-tumour function in vitro and in vivo.

Shoichi Iriguchi
Yutaka Yasui
Shin Kaneko
ResearchOpen Access18 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Influenza virus uses transportin 1 for vRNP debundling during cell entry

A member of the importin-β protein family, transportin 1, binds to influenza A virus matrix protein M1 and promotes its removal from the viral ribonucleoproteins (vRNPs), enabling disassembly of vRNP bundles, vRNP interaction with importin-α/β and entry into the nucleus.

Yasuyuki Miyake
Jeremy J. Keusch
Yohei Yamauchi
Research28 Jan 2019
Nature Microbiology

Volume: 4, P: 578-586
Acetylation site specificities of lysine deacetylase inhibitors in human cells

Comprehensive analysis of changes in protein acetylation in response to lysine deacetylase inhibitors uncovers inhibitor specificities.

Christian Schölz
Brian T Weinert
Chunaram Choudhary
Research09 Mar 2015
Nature Biotechnology

Volume: 33, P: 415-423
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

Shigeru Chiba and colleagues report exome sequencing of angioimmunoblastic T cell lymphoma (AITL) and other peripheral T cell lymphomas and identify a recurrent somatic RHOA mutation encoding a p.Gly17Val alteration in 68% of AITL samples.

Mamiko Sakata-Yanagimoto
Terukazu Enami
Shigeru Chiba
Research12 Jan 2014
Nature Genetics

Volume: 46, P: 171-175
Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Taito Miyake
Norihiko Sakai
Takashi Wada
ResearchOpen Access31 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Norihiko Sakai
Miki Nakamura
Takashi Wada
ResearchOpen Access14 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

Ryouichi Horie
Takuro Watanabe
Toshiki Watanabe
Research18 Apr 2002
Oncogene

Volume: 21, P: 2493-2503
Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma

K Miyahara
K Nouso
Hiroki Takayama
ResearchOpen Access17 Sept 2013
British Journal of Cancer

Volume: 109, P: 2072-2078

Search

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image

PI ^* S _iiyama, a deficiency gene of alpha₁-antitrypsin: Evidence for the occurrence in western Japan

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Influenza virus uses transportin 1 for vRNP debundling during cell entry

Acetylation site specificities of lysine deacetylase inhibitors in human cells

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis

Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cells

Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma

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