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Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Chenfei Lu
Tao Kang
Xiuxing Wang
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-21
Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing atlas of both species to define these features and to find reduced evolutionary diversification of immune cells in cartilaginous fishes.

Hong-Yan Wang
Jian-Yang Chen
Changwei Shao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-17
UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing

UDA-seq incorporates a post-indexing step to enhance the throughput of droplet-based single-cell multimodal sequencing, enabling efficient large-scale single-cell analysis.

Yun Li
Zheng Huang
Lan Jiang
ResearchOpen Access20 Jan 2025
Nature Methods

P: 1-14
Feasibility and case studies on converting small hydropower stations to pumped storage

Yangqing Dan
Qingyue Chen
Jia Yang
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-19
A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation

Shao et al. report that FUS interacts with the transcriptional coactivator TAZ, maintaining liquid-like properties of TAZ biomolecular condensates and enhancing TAZ transcriptional activity.

Yangqing Shao
Xin Shu
Huasong Lu
Research03 Jan 2024
Nature Cell Biology

Volume: 26, P: 86-99
Impact of SARS-CoV-2 infection on respiratory and gut microbiome stability: a metagenomic investigation in long-term-hospitalized COVID-19 patients

Zhengtu Li
Jing Chen
Feng Ye
ResearchOpen Access13 Nov 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-11
The gut microbiome in atherosclerotic cardiovascular disease

The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease.

Zhuye Jie
Huihua Xia
Karsten Kristiansen
ResearchOpen Access10 Oct 2017
Nature Communications

Volume: 8, P: 1-12
Rho kinase inhibitor Y-27632 downregulates IL-1β expression in mice with experimental autoimmune myocarditis

Yanjun Li
Ge Gao
Yuxing Wang
ResearchOpen Access29 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
A metagenome-wide association study of gut microbiota in type 2 diabetes

The authors have developed a new method, metagenome-wide association study (MGWAS), to compare the combined genetic content of the faecal microbiota of healthy people versus patients with type 2 diabetes; they identify multiple microbial species and metabolic pathways that are associated with either cohort and show that some of these may be used as biomarkers.

Junjie Qin
Yingrui Li
Jun Wang
Research26 Sept 2012
Nature

Volume: 490, P: 55-60
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

Fu, et al. report that PARP1-dependent poly(ADP-ribsoyl)ation of the P-TEFb subunit CycT1 suppresses its phase separation, which prevents its interaction partner CDK9 from hyperphosphorylating RNA polymerase II and thereby blocks transcription.

Huanyi Fu
Rongdiao Liu
Qiang Zhou
Research07 Apr 2022
Nature Cell Biology

Volume: 24, P: 513-525
Laparoscopic versus open surgery for liver resection: a multicenter cohort study

Yesheng Li
Longrong Wang
Lu Wang
ResearchOpen Access02 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages

Daqi Li
Xiefeng Wang
Xiuxing Wang
Research09 Apr 2024
Cell Death & Differentiation

Volume: 31, P: 738-752
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Danyang Chong
Yayun Gu
Chaojun Li
ResearchOpen Access11 Oct 2022
Cell Discovery

Volume: 8, P: 1-19
Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity

Jiandong Yuan
Wenlang Liu
Zheng Zheng
ResearchOpen Access19 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

Hang Xie
Xiu-Feng Wan
Yanhong Zhu
ResearchOpen Access16 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Construction of porous cationic frameworks by crosslinking polyhedral oligomeric silsesquioxane units with N-heterocyclic linkers

Guojian Chen
Yu Zhou
Jun Wang
ResearchOpen Access11 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
CircATRNL1 promotes epithelial–mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro

Dandan Wang
Yajuan Luo
Qing Yang
ResearchOpen Access29 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-13

Search

Combined targeting of glioblastoma stem cells of different cellular states disrupts malignant progression

Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing

Feasibility and case studies on converting small hydropower stations to pumped storage

A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation

Impact of SARS-CoV-2 infection on respiratory and gut microbiome stability: a metagenomic investigation in long-term-hospitalized COVID-19 patients

The gut microbiome in atherosclerotic cardiovascular disease

Rho kinase inhibitor Y-27632 downregulates IL-1β expression in mice with experimental autoimmune myocarditis

A metagenome-wide association study of gut microbiota in type 2 diabetes

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

Laparoscopic versus open surgery for liver resection: a multicenter cohort study

IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity

H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

Construction of porous cationic frameworks by crosslinking polyhedral oligomeric silsesquioxane units with N-heterocyclic linkers

CircATRNL1 promotes epithelial–mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro

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