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This study utilizes Stereo-seq to comprehensively map the geospatial architecture of breast cancer, revealing venular niches that promote immune infiltration and better clinical outcomes, offering new insights into tumor microenvironment regulation.

In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Powdery mildew disease seriously threatens wheat production by reducing grain yield and quality. Here, the authors clone the Znf-BED-bearing NLR protein encoding powdery mildew resistance gene Pm6Sl derived from wild wheat species Aegilops longissima and show its application in breeding resistance cultivars.

Up to now, all iron-based high-T_c superconductors contain a square iron lattice. Here, Wang et al. report the observation of superconductivity in an iron honeycomb lattice accompanied with pressure-driven spin-crossover, in-plane lattice collapse and insulator-metal transition.

Powdery mildew is a fungal leaf disease that reduces yield and grain quality in susceptible wheat varieties. Here, the authors report the cloning of the wild emmer wheat originated powdery mildew resistance gene Pm36 as a membrane associated tandem kinase and its possible resistance mechanism.

Invariant natural killer T (iNKT) cells are important contributors to anti-tumour immunity, but they often become dysfunctional in cancers. Here authors show that inhibited iNKT intra-tumour motility and iNKT cell exclusion from tumours by macrophages both contribute to their diminished function in cancer, and by therapeutic interference with the respective motility and iNKT-macrophage interaction pathways, their function can be restored.

All-solid-state electrolytes for lithium batteries generally suffer from low ionic conductivity. Here, authors manipulate the lattice of antiperovskite-type Li₂OHCl by potassium ion substitution, which alters the lattice structure and improves the lithium ion transport properties.

The authors find that slow plant growth at low temperatures during winter reduces dilution of the transcription factor NTL8, which allows slow accumulation of NTL8 and thus the gradual increase in transcription of VIN3—a gene involved in memory of cold exposure.

Comprehensive poly(A)-inclusive RNA isoform sequencing throughout the human oocyte and preimplantation embryo development reveals poly(A)-tail-mediated maternal mRNA remodeling that is essential for human embryo development.

Carbon monoxide clathrate hydrate has been widely studied and although the structure-II gas hydrate is predicted to be thermodynamically favourable, it is the structure-I hydrate that has been observed. Here, the authors synthesize the structure-II carbon monoxide hydrate and probe its structure and formation.

Apolipoprotein E (APOE) is a lipoprotein particle component and is genetically linked to human longevity and Alzheimer’s disease; however, the mechanisms that link APOE and aging are incompletely understood. Here, Zhao et al. show that APOE drives cellular senescence in aged human mesenchymal progenitor cells by destabilizing heterochromatin.

High-density, intrinsically stretchable transistors with high driving ability and integrated circuits with high operation speed and large-scale integration were enabled by a combination of innovations in materials, fabrication process design, device engineering and circuit design.

A stretchable ultrasonic array conforming to the skin allows for the three-dimensional imaging of tissue modulus at depths of up to 4 cm.

Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

Multi-frame super-resolution microscopy is hampered by long acquisition times and phototoxicity, which hinder its use for live-cell imaging. Here, authors propose a deep-learning-based single-frame super-resolution approach to image cellular dynamics with high spatiotemporal resolution.

While photoredox catalysis presents exciting avenues for molecular transformations, balancing optimal photochemical and materials properties can be challenging. Here, the authors prepare carbon-coated In₂O₃ nanoparticles as recoverable photocatalysts for arylboronic acid oxidative hydroxylation.

Implementation of a genomics-informed prebreeding strategy in a global winter wheat collection enhances the use of genebank accessions and uncovers the value of genetic resources for wheat improvement.

Pressure can either make materials more disordered, like amorphization, or more thermodynamic stable, yet the switching between the two metastable phases has not been described. Wang et al. study it in vanadium oxide nanosheets and highlight the role played by spin and charge during the transition.

Degradation and low conductivity of transition metal oxide anodes cause capacity fading in lithium ion batteries. Here the authors make freestanding 3D copper oxide/carbon nitride core-shell nanoarrays which accommodate volume change, provide electro-active zones and facilitate rapid charge transport.

A three-dimensional field-effect transistor array produced via compressive buckling enables accurate and minimally invasive intra- and intercellular recordings in cells and cellular networks.

Lithium metal batteries suffer from the dendrite growth upon electrochemical cycling. Here the authors introduce a lithiophilic-lithiophobic gradient interfacial ZnO/CNT layer, which facilitates the formation of a stable solid electrolyte interphase, and suppresses the growth of lithium dendrite.

Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations.

Analysis of genotyping-by-sequencing data for more than 20,000 barley accessions from a German genebank provides a framework for genomics-assisted genebank management and analysis of large germplasm collections for important crops.

Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.

Draft genome, 994 re-sequenced lines and GWAS for yield-traits provide a resource of genetics and genomics tools for pearl millet researchers and breeders.

Analysis of a large bread-wheat genomic data set through a quantitative genetic framework designed to study the genetic basis of heterosis shows that hybrids outperform midparents in grain yield by 10%. Genome-wide prediction and association mapping indicate that epistasis plays a significant role in heterosis of grain yield in wheat.

Training a deep neural network can be costly but training time is reduced when a pre-trained network can be adapted to different use cases. Ideally, only a small number of parameters needs to be changed in this process of fine-tuning, which can then be more easily distributed. In this Analysis, different methods of fine-tuning with only a small number of parameters are compared on a large set of natural language processing tasks.