Nature Search

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Adaptive immune responses associated with the progression of premalignant lesions to colorectal cancer

Zhishan Chen
Dongwoo Kim
Jungyoon Choi
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes

Here, the authors integrate genomic and transcriptomic data obtained from African-ancestry female participants and identify six genes associated with breast cancer risk which provides biological insights into this common cancer in an underrepresented population.

Jie Ping
Guochong Jia
Wei Zheng
ResearchOpen Access02 May 2024
Nature Communications

Volume: 15, P: 1-8
Rhizosphere soil properties may not determine tobacco growth after land consolidation

Taige Yu
Rong Jia
Huadong Zang
ResearchOpen Access17 Oct 2025
Scientific Reports

Volume: 15, P: 1-8
Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk

The relationship between tissue-specific DNA methylation and cancer risk remains to be elucidated. Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk.

Yaohua Yang
Yaxin Chen
Jirong Long
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers

Transcriptome-wide association studies can uncover genes involved in disease. Here, the authors extend the framework with a transcriptome-wide association study approach which incorporates transcription factor occupancy, adding tissue-specific mechanistic support to associations.

Jingni He
Wanqing Wen
Xingyi Guo
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions

Multi-ancestry fine-mapping of breast cancer susceptibility regions identifies candidate causal variants and prioritizes likely effector genes supported by functional genomic evidence.

Guochong Jia
Zhishan Chen
Wei Zheng
Research03 Jan 2025
Nature Genetics

Volume: 57, P: 80-87
Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility

The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FOXA1 and co-factors.

Wanqing Wen
Zhishan Chen
Xingyi Guo
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-12
Retention of high-pressure solution-processable metastable phase to ambience via differential sublattice rigidity for broadband photodetectors

Li et al. report the sublattice decoupling in Rb₆Re₆S₈I₈ upon compression, in which [Rb₆I₂]⁴⁺ framework can be selectively amorphized while the [Re₆S₈I₆]^4- clusters keep in ordered state, leading to emission-to-photocurrent switching at 15 GPa, which can retain when back to ambient condition.

Zhongyang Li
Jue Gong
Gang Liu
ResearchOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction

Genome-wide association analyses identify risk loci for breast cancer in women of African ancestry. Polygenic risk scores derived from these data improve ancestry-specific risk prediction.

Guochong Jia
Jie Ping
Wei Zheng
Research13 May 2024
Nature Genetics

Volume: 56, P: 819-826
Large-scale foundation model on single-cell transcriptomics

scFoundation, with 100 million parameters covering about 20,000 genes, pretrained on over 50 million single-cell transcriptomics profiles, is a foundation model for diverse tasks of single-cell analysis.

Minsheng Hao
Jing Gong
Le Song
Research06 Jun 2024
Nature Methods

Volume: 21, P: 1481-1491
The pharmacokinetic-nephrotoxicity relationships of CMS and CMS-E2 from the perspective of plasma and kidney drug concentrations in rats

Chenxue Guo
Lin Xi
Jing Zhang
ResearchOpen Access10 May 2025
Scientific Reports

Volume: 15, P: 1-14
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomisation analysis

Xiang Shu
Qin Zhou
Jonine L. Bernstein
Research26 Jul 2022
British Journal of Cancer

Volume: 127, P: 1507-1514
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

Lang Wu
Wei Shi
Wei Zheng
Research18 Jun 2018
Nature Genetics

Volume: 50, P: 968-978
High-throughput fabrication of soft magneto-origami machines

Machines capable of magnetically controllable shape morphing and locomotion have diverse promising applications. Here, authors propose a scalable fabrication strategy that transforms 2D magnetic sheets into 3D soft magneto-active machines with customized geometries by incorporating origami folding.

Shengzhu Yi
Liu Wang
Lelun Jiang
ResearchOpen Access19 Jul 2022
Nature Communications

Volume: 13, P: 1-11
First-principles insights on the electronic and optical properties of ZnO@CNT core@shell nanostructure

Yang Shen
Xiaodong Yang
Shulin Gu
ResearchOpen Access18 Oct 2018
Scientific Reports

Volume: 8, P: 1-9
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

In breast cancer, genome-wide associations studies (GWAS) have highlighted loci associated with disease risk. Here, the authors perform a meta-analysis of GWAS data from Asian populations, discovering 31 potential new risk loci, 10 of which are validated in an independent disease cohort.

Xiang Shu
Jirong Long
Wei Zheng
ResearchOpen Access05 Mar 2020
Nature Communications

Volume: 11, P: 1-9
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

Genome wide association studies have identified multiple loci associated with risk of developing prostate cancer but the functional significance of many of these are unknown. Here, after generating models to predict methylation, the authors identify CpG methylation sites associated with prostate cancer.

Lang Wu
Yaohua Yang
Stella Koutros
ResearchOpen Access06 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Anti-inflammatory and barrier repair mechanisms of active components in Daemonorops draco Bl. for UVB-induced skin damage

Xingyi Wu
Ying Zhang
Li Li
ResearchOpen Access17 May 2025
Scientific Reports

Volume: 15, P: 1-15
Pakistan is failing in maternal and neonatal tetanus elimination

Suliman Khan
Xingyi Guo
Usman Ayub Awan
Correspondence07 Feb 2024
Nature Medicine

Volume: 30, P: 615
Effect of jaw width in jaw tracking mode on the radiotherapy dose of partial arc VMAT in patients undergoing left breast-conserving surgery

Hai-liang Guo
Yan Huan
Huai-wen Zhang
ResearchOpen Access09 May 2025
Scientific Reports

Volume: 15, P: 1-12
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Wanqing Wen
Norihiro Kato
Xiao-Ou Shu
ResearchOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Materials for solar-powered water evaporation

Materials engineering enables the control of water–material interactions in solar vapour generators, which aim to efficiently utilize solar energy for the cost-effective production of clean water. This Review discusses material-design principles for solar evaporators, spanning from macrostructures to molecular configurations.

Fei Zhao
Youhong Guo
Guihua Yu
Reviews10 Mar 2020
Nature Reviews Materials

Volume: 5, P: 388-401
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

Gastrointestinal stromal tumours (GIST) are believed to arise in interstitial cells of Cajal (ICC). These authors show that the transcription factor ETV1 is required for ICC development and promotes the development of GIST. KIT, which is often activated by mutations in GIST, cooperates with ETV1 in the transformation of ICCs, in part by promoting ETV1 stabilization. Thus, a normal developmental lineage factor is switched into a tumour-promoting factor by a cooperating oncogene.

Ping Chi
Yu Chen
Charles L. Sawyers
Research03 Oct 2010
Nature

Volume: 467, P: 849-853
Research on “theory of force-center” based on failure characteristics of different roadway sections and its application

Su Hengyu
Luo Chang
Jia Yichao
ResearchOpen Access07 Mar 2025
Scientific Reports

Volume: 15, P: 1-26
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Amendments and Corrections13 Feb 2023
Nature Genetics

Volume: 55, P: 519-520
Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis

Yuxia Zhou
Guifang Wang
Bing Guo
ResearchOpen Access20 May 2025
Cell Death & Disease

Volume: 16, P: 1-16
A proteome-wide association study identifies putative causal proteins for breast cancer risk

Tianying Zhao
Shuai Xu
Jirong Long
ResearchOpen Access28 Oct 2024
British Journal of Cancer

Volume: 131, P: 1796-1804
Topology optimization design of three-dimensional multi-material and multi-body structure based on irregular cellular hybrid cellular automata method

Xiaolei Deng
Hongxi Chen
Ting Fu
ResearchOpen Access04 Apr 2022
Scientific Reports

Volume: 12, P: 1-20
Construction of a high-density genetic map based on large-scale marker development in Coix lacryma-jobi L. using specific-locus amplified fragment sequencing (slaf-seq)

Chenglong Yang
Xiuwen Ban
Jianchun Guo
ResearchOpen Access26 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
Flexible yet impermeable composites with wrinkle structured BNNSs assembling for high-performance thermal management

Guilei Guo
Yijie Liu
Bin Sun
ResearchOpen Access31 May 2024
npj Flexible Electronics

Volume: 8, P: 1-9
Integrating genomics and proteomics data to identify candidate plasma biomarkers for lung cancer risk among European descendants

Yaohua Yang
Shuai Xu
Qiuyin Cai
Research07 Sept 2023
British Journal of Cancer

Volume: 129, P: 1510-1515
Long intergenic non-coding RNA expression signature in human breast cancer

Yanfeng Zhang
Erin K. Wagner
Jirong Long
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
De novo assembly and analysis of the Artemisia argyi transcriptome and identification of genes involved in terpenoid biosynthesis

Miaomiao Liu
Jinhang Zhu
Meiqi Zhou
ResearchOpen Access11 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial

Jing Zhao
Ayush Giri
Qi Dai
ResearchOpen Access23 Sept 2019
British Journal of Cancer

Volume: 121, P: 796-804
HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer

Yue Xue
Wenwen Lian
Qingqing Wang
ResearchOpen Access06 Nov 2019
British Journal of Cancer

Volume: 121, P: 1039-1049
Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Fei Li
Diping Song
Daniel S. W. Ting
ResearchOpen Access22 Sept 2020
npj Digital Medicine

Volume: 3, P: 1-8

Search

Filter By:

Search

Quick links