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Traditional lithographic techniques could damage organic semiconductor crystals due to high-energy beams or solvents. Here, authors employ a chemical-free nanoimprint crystallography method for fabrication of independent complex 2D patterns that exhibit good lasing performance and reproducibility.

Layers of transition metal dichalcogenides (TMDs) are generally formed by covalently bonded atoms, enabling mechanical exfoliation only in the out-of-plane direction. Here, the authors show the fabrication of fractional 2/3-layers of WTe₂ and other TMDs by applying local scanning tunneling microscopy tip pulses and controllably removing the topmost chalcogen atoms.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

The use of Raman spectroscopy in biochemical applications has been hindered by several limitations. Here, the authors present a fiber-array Raman engine, termed FIRE. This tool features a dynamic single-channel photon-counting detector and is used for full Raman spectral imaging in biological samples and whole organisms.

Understanding the electrical double layer at solid-liquid interfaces is crucial for various technologies. Here, the authors present an optical method for direct visualization and quantification of the zeta potential at 2D material interfaces.

Glycosylated asparagine residues that mediate the function of the B7H3 protein are unclear. Here the authors identify the important N-glycosylation sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially targeting monoclonal antibody manifesting enhanced antitumor immunity.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV₃Sb₅ that indicates broken symmetries and intrinsic chirality.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.

Abnormal T cell proliferation often triggers autoimmune disorders. Here the authors show that T cell-specific deficiency of the enzyme N-acetyltransferase 10 ameliorates experimental autoimmune encephalitis potentially by RACK1-mediated regulation of T cell metabolism and expansion.

Reactive capture—integrating CO₂ capture and electrochemical valorization—improves energy efficiency by eliminating gas-phase CO₂ desorption. Here, authors design a redox-active polymeric network to boost the direct conversion of captured CO₂ to multicarbon products with CO₂-free gas product stream.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Focal cortical dysplasia type II causes epileptic seizures and is associated with various types of neuronal abnormalities. This study uses patient tissue transcriptomics and animal models to reveal that vascular malformations are a key part of the pathology by creating ischemic-hypoxic microenvironments.

Existing method struggles with CHH methylation detection from the reads generated by the latest ONT technology. Here, the authors developed a deep learning model that can significantly improve CHH detection accuracy in plants.

Hydrogen production coupled with electrochemical oxidation of organic nucleophiles is often limited by catalyst’s reconstruction at the anode. Here, the authors developed the stable Ni(II) active sites in Prussian Blue analogue for fast, selective ethylene glycol electrooxidation and constructed an effective coupled electrochemical hydrogen production flow cell.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models

C(sp³)–Cl bonds are present in numerous biologically active molecules and can also be used as a site for diversification by substitution or cross-coupling reactions. Here, the authors report a remote internal site-selective C(sp³)–H bond chlorination of alkenes through sequential alkene isomerization and hydrochlorination, enabling the synthesis of both benzylic and tertiary chlorides with excellent site-selectivity.

Evaluating the off-target effect is crucial for ensuring the safety of CRISPR–Cas9-based technologies. Duan, Gao and Zhang et al. developed TOPO-seq, a method to capture and evaluate DNA topology-regulated off-target activity of Cas9-based genome-editing tools.

Colored functional layers are transformed into imperceptible functional meshes. In doing so, various see-through devices are no longer susceptible to the color or opacity of the functional materials and have enhanced transparency.

Pulmonary artery-vein segmentation is essential for disease diagnosis but has not been used with non-contrast CT. Here the authors developed HiPaS, a deep learning method which enables this with no inferiority to CTPA performance and a large-scale anatomical study using HiPaS reveals pulmonary vessel differences associated with sex, age, and disease.

Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondrial function, reduce mitophagy, and reduce ataxia.

LYTAC strategies often face challenges in solid tumor penetration and synthesis. Here, the authors introduce Pep-TACs, a modular TFRC-based covalent peptide degradation platform that effectively degrades membrane protein PD-L1. This approach significantly suppresses both anti-PD-1-responsive and -resistant tumor growth, particularly in brain tumors.

A Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized for the piezocatalytic uranium extraction from seawater, helping to realize efficient uranium extraction by wave energy

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

The molecular phenotypic features of epithelial ovarian cancer (EOC) remain elusive. Here, the authors perform mass spectrometry-based proteomic profiling for 269 EOC patients and reveal molecularly distinct features and potential therapeutic targets among the histological subtypes of EOC.

The authors demonstrate that warming will reduce connectivity for ocean species, potentially limiting their capacity to adapt to warming through habitat shifts. The results show particularly strong losses of connectivity in deeper ocean strata, affecting 95% of abyssopelagic species.

Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ATT2, by enabling the fine-tuning of gibberellins, is expected to be a potential new post-Green Revolution gene.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

This study presents an electrochemical approach to construct C–S bonds through the reaction of SO₃²⁻ with electrophilic intermediates generated from the electrochemical oxidation of biomass derivatives, including methanol. This method achieves high Faradaic efficiencies and industrial-scale production rates of organosulfur compounds, such as hydroxymethanesulfonate, sulfoacetate and methanesulfonate.

Here, the authors report a Ni(cluster)/TiO₂ catalyst with strong interactions between Ni and −OH strong to promote CO₂ activation with CO adsorption to avoid the activity-selectivity trade-off of the reverse water gas shift reaction.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

Adverse cardiac remodelling is a key process leading to heart failure. Here, the authors show that expression of foetal gene Pontin (Ruvbl1) is protective against pathological remodelling and cardiomyopathy via modulation of the Hippo pathway.

Secondary phases or multi-step phase formation lead to poorly crystallized and defective kesterite films. Now Zhou et al. convert precursors into kesterite in a single step, using low partial pressure of selenium, and achieve solar cells with 13.8% certified efficiency.

The expression levels of NEK4 have been associated with bipolar disorder in GWAS. Here, the authors examine the physiological effects of overexpressing NEK4 in the hippocampus of mice, showing that it leads to aberrations in circadian traits.