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Artificial intelligence-based studies for breast cancer magnetic resonance imaging (MRI) predominantly rely on single sequences and have limited validation. Here, the authors develop a mixture-of-modality-experts model (MOME) that integrates multiparametric breast cancer MRI information within a unified structure, which shows reliable performance in a large cohort.

This study evaluates bias in AI-generated medical text, revealing disparities across race, sex and age. An optimization method is proposed to enhance fairness without compromising performance, offering a step toward more equitable AI in healthcare.

Layers of transition metal dichalcogenides (TMDs) are generally formed by covalently bonded atoms, enabling mechanical exfoliation only in the out-of-plane direction. Here, the authors show the fabrication of fractional 2/3-layers of WTe₂ and other TMDs by applying local scanning tunneling microscopy tip pulses and controllably removing the topmost chalcogen atoms.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Understanding the electrical double layer at solid-liquid interfaces is crucial for various technologies. Here, the authors present an optical method for direct visualization and quantification of the zeta potential at 2D material interfaces.

Local structure control is challenging in high entropy alloy (HEA) catalysts. Here, the authors report finely tailoring the local clustering in HEA catalysts through rational composition design and sequential pulse annealing, achieving enhanced activity and stability for ethanol electrooxidation.

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

The authors realize the enhancement of energy storage performance of NaNbO3-based multilayer ceramic capacitors guided by phase-field simulation through the design of directional slush-like structures.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

Study reveals coeval rapid uplift and normal faulting along the Central Anatolian Plateau’s southern margin. U-Th dating of fault-related calcites deciphers active deformation above the Cyprus Subduction, linking deep mantle and surface processes.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

Pulmonary artery-vein segmentation is essential for disease diagnosis but has not been used with non-contrast CT. Here the authors developed HiPaS, a deep learning method which enables this with no inferiority to CTPA performance and a large-scale anatomical study using HiPaS reveals pulmonary vessel differences associated with sex, age, and disease.

Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia/reperfusion injury.

The use of Raman spectroscopy in biochemical applications has been hindered by several limitations. Here, the authors present a fiber-array Raman engine, termed FIRE. This tool features a dynamic single-channel photon-counting detector and is used for full Raman spectral imaging in biological samples and whole organisms.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Hydrogen production coupled with electrochemical oxidation of organic nucleophiles is often limited by catalyst’s reconstruction at the anode. Here, the authors developed the stable Ni(II) active sites in Prussian Blue analogue for fast, selective ethylene glycol electrooxidation and constructed an effective coupled electrochemical hydrogen production flow cell.

Cerebellar cognitive affective syndrome features non-motor dysfunctions such as anxiety. Here, authors show that the cerebellum projects to zona incerta through excitatory and inhibitory transmissions to modulate anxiety in a plasticity-dependent manner.

Yang et al. developed a new method, BEPH, a foundation model trained on TCGA WSI images. BEPH improves cancer recognition, classification, and survival prediction across subtypes, potentially reducing reliance on expert annotations.

HPS is a rare autosomal recessive disorder that cause dysfunctions of the lungs, intestine, kidneys, and heart. Here, the authors report the structure of the BLOC complex, BLOC-3 and provides a framework to understand how BLOC-3 cooperates with Rab GTPases (RAB32/38 and RAB9A) to regulate the biogenesis of lysosome-related organelles.

Accurate detection of nostril airflow is vital for real-time respiratory monitoring, however, existing methods can only detect a single stimulus of nostril airflow. This report describes a crosslinked eutectogel for simultaneous and independent sensing of pressure and temperature for the nostril airflow.

Colored functional layers are transformed into imperceptible functional meshes. In doing so, various see-through devices are no longer susceptible to the color or opacity of the functional materials and have enhanced transparency.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Reactive capture—integrating CO₂ capture and electrochemical valorization—improves energy efficiency by eliminating gas-phase CO₂ desorption. Here, authors design a redox-active polymeric network to boost the direct conversion of captured CO₂ to multicarbon products with CO₂-free gas product stream.

Glycosylated asparagine residues that mediate the function of the B7H3 protein are unclear. Here the authors identify the important N-glycosylation sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially targeting monoclonal antibody manifesting enhanced antitumor immunity.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

This study presents iKraph, a large-scale biomedical knowledge graph built using an award-winning natural language processing pipeline with expert-level accuracy. Using probabilistic semantic reasoning, iKraph enables automated knowledge discovery with excellent performance.

Unlocking the potential of traditional nanomaterials like spinel oxides is crucial for improving the catalytic oxygen evolution reaction. Here, the authors report an inorganic–organic hybrid spinel oxide that enhances both catalytic activity and structural stability through a coordination method.

CNS injuries cause persistent deficits. Here, the authors show that regenerated axons in an optic tract injury model form functional synapses, restoring the pupillary light reflex, and highlight neuronal types and presynaptic activity in recovery.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

Secondary phases or multi-step phase formation lead to poorly crystallized and defective kesterite films. Now Zhou et al. convert precursors into kesterite in a single step, using low partial pressure of selenium, and achieve solar cells with 13.8% certified efficiency.

This work reveals an unusual T⁴ temperature dependence of the electronic thermal conductivity at ultralow temperatures and a strong violation of the Wiedemann-Franz law in the topological compensated semimetals TaAs₂, NbAs₂, and NdSb.

Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, the authors develop scNiche, a computational framework to identify and characterise cell niches from spatial omics data at single-cell resolution.

Biomolecular condensates play essential roles in regulating physiological events in biological systems, and while multiphasic condensates have been studied, condensates derived from a single component of short peptides were not reported. Here, the authors present the symmetrical core-shell structural biomolecular condensates formed with a programmable tetrapeptide library via phase separation, and show that tryptophan is key for core-shell structure formation.

Evaluating the off-target effect is crucial for ensuring the safety of CRISPR–Cas9-based technologies. Duan, Gao and Zhang et al. developed TOPO-seq, a method to capture and evaluate DNA topology-regulated off-target activity of Cas9-based genome-editing tools.

This study explores N–heterocyclic carbene copper complexes toward selective electrocatalytic reduction of acetylene to ethylene. The electron–rich copper sites were found to facilitate acetylene adsorption and ethylene desorption and achieved high activity and selectivity for ethylene production.

The compact Cas12f enzyme exhibits obvious delivery advantage for gene editing, but its activity remains suboptimal. Here, the authors have designed and optimized circular guide RNA (cgRNA) for Cas12f, which significantly improves the efficiency of gene activation and adenine base editing.

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

Microbial interactions of the honey bee gut microbiome are incompletely understood. Here, the authors report a reciprocal interaction between two core bacterial genera: Bifidobacterium aids in demethylation of the pectin backbone enabling its breakdown by Gilliamella; in return, Gilliamella shares digestion products.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

The authors obtain the TiCoSb-based single-crystals with a dimension exceeding 1 cm, leading to an extraordinary enhancement in electron mobility and consequently, an average power factor of 37 W cm⁻¹ K⁻² in the Nb-doped TiCoSb single-crystal.

INSM1 is a key regulator of neuroendocrine differentiation and a biomarker for tumorigenesis. Here, the authors reveal the dynamic conformations of its five zinc fingers and show how INSM1 cooperates with TEAD1 and CTCF to regulate transcription by targeting specific genomic loci.

Iminium-catalysed cycloaddition is a prominent example of organocatalytic reactivity, yet a biological counterpart has not been identified. Now, the authors report biochemical, structural and computational evidence for iminium catalysis by the natural Diels–Alderase SdnG.

Succinylation of PD-L1 by carnitine palmitoyltransferase 1A (CPT1A) in melanoma leads to its degradation and enhanced T cell-dependent killing in vitro. Increasing CPT1A levels synergizes with anti-CTLA-4 treatment to suppress tumor growth in a mouse melanoma model.

The luminescence efficiency of lanthanide-doped nanoparticles is limited by surface-related energy losses. Here the authors show how coordination of small organic molecules can increase the material brightness over a broad temperature range.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

Early-onset lung cancer in young adults remains poorly studied. Here, the authors analyse the clinicopathological, molecular, and immune features of early-onset non-small cell lung cancers in a cohort of 421 patients across ten medical centres in China, identifying potential therapeutic strategies for this subgroup.