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Aluminum has been considered a promising alloy-type negative electrode for all-solid-state batteries. Here, the authors introduce a comprehensive study of β-LiAl phase-dependent Li⁺ kinetics and microstructural evolution, leading to the demonstration of an optimized high-loading Li-Al-based cell.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

The authors show that hot-pressing markedly improves high-power performance. In the hot-pressing process, the combined effect of applied pressure and sintering aids reduces the sintering temperature, which not only minimizes lead volatilization but also promotes densification.

Planar oxygen-doped carbon quantum rings (OD-CQRs) are prepared through one-pot solid-state reactions. The synthesized OD-CQRs exhibit a fluorescence peak centre at 393 nm, a full-width at half-maximum of 18 nm and a photoluminescence quantum yield of 95%. Electroluminescent light emitting diodes based on OD-CQRs demonstrate high-colour-purity violet emission.

Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1is critical for regulating panicle seed setting rate and pollen tube growth.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Cholesterol-patterned nanoparticles program gel-like stress granule condensates via a solid–liquid–liquid sequence, reveal dual proteasomal disassembly routes, and permit tissue-specific remodeling of chemoplasticity to decouple efficacy from toxicity in vivo.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based therapies.

Yan et al. use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes epigenetic regulation.

DISC1 attenuates Zika virus infection and congenital Zika syndrome by promoting autophagy via AMPK-mTOR signaling and is implicated in ZIKV-induced long-term neurological deficits.

Wound biomarker monitoring faces challenges in both sensitivity and stability. Here, authors present soft wireless bioelectronic device, using self-confined tetrahedral DNA circuits, that enhance detection limits, resists biofouling, and enables stable and real-time monitoring of diabetic wound healing.

Here the authors report that genetic or pharmacological inhibition of phosphoglycerate kinase 1, an enzyme involved in glycolysis, attenuates acute kidney injury in mouse models of acute kidney injury via inhibition of ferroptosis.

The authors present ARPES measurements on the triple-layer cuprate superconductor Bi₂Sr₂Ca₂Cu₃O_10+δ. They find that, although the doping level of the inner CuO₂ plane is extremely low in under-doped samples, the d-wave superconducting gap is enhanced at the antinode and persists well above T_c without a Fermi arc, indicating a “nodal metal”.

The hydrovoltaic effect offers a promising route for ion sensing but is limited by a long response time. Here, the authors leverage rapid ion transport within nanochannels to achieve a high voltage output of 4.0 V with a response time of just 0.17 s.

This investigation pioneers in situ capacitance experimentation in BaTiO₃-based multilayer ceramic capacitors, and reports three radiation response mechanisms: total ionizing dose effect, enhanced low dose rate sensitivity effect, and self-recovery effect.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

Sun et al. reveal that root-knot nematode attack activates a phyB-HY5 cascade that integrates light and GLR3.5-CaM2 signals to boost JA synthesis in tomato, with HY5 moving from leaves to roots to sustain signaling and trigger JA-mediated defense.

Radiative cooling is an emerging technology for cooling with reduced energy consumption. Here the authors present photoluminescent composites that combine subambient cooling with aesthetic colour, hydrophobicity and durability.

This study presents FolTAC-dual, a folate receptor-mediated platform for dual degradation of EGFR/HER2 and PD-L1/VISTA, offering a strategy to overcome drug resistance and enhance antitumor immunity for cancer treatment.

Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

Designing two-dimensional membranes to achieve tailored channels while ensuring stability remains challenging. Here, the authors use multifunctional intercalants to create stable, selective subnanochannels in MoS₂ membranes, demonstrating their potential in wastewater treatment.

Energy density and cyclability are often a trade-off for lithium-ion batteries. The authors develop cobalt- and nickel-free cathodes with both good cycling stability and high energy density through the integration of polyanion units into rocksalt structures.

Organ metabolic crosstalk is vital but challenging to trace. Here, the authors present MSITracer, a computational tool for spatial isotope tracing that reveals inter-organ crosstalk, such as liver–heart fatty acid metabolism and lung-derived glutamine catabolism in tumors.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

Researchers use a chimeric approach to reveal the first near-atomic resolution structures the yellow fever virion, showing key differences between vaccine and virulent strains that affect how antibodies recognise and neutralise the virus.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

Radiosensitising agents can enhance radiotherapy and improve outcomes. Here, the authors report on the design of bioinspired Radiosensitising and biocatalytic nanoparticles to increase radiation tiggered cell death and immunogenic response to combat both primary and metastatic tumours.

Space-charge layers are believed to profoundly influence the interfaces in all-solid-state Li batteries. Here, the authors provide atomic scale insights into this phenomenon, and discover that its impact could be fundamentally different from commonly believed.

All-solid-state batteries with silicon anodes have high capacities but low initial coulombic efficiencies (ICEs) because of first cycle irreversible capacity loss. Here, the authors report a prelithiation strategy to improve ICEs and reversibility.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney failure. This study shows that prolonged glucagon exacerbates lipid accumulation, promoting renal injury in early DKD, rather than lipid oxidation. Targeting glucagon signaling significantly inhibits DKD progression.

This study quantitatively identifies contaminant loss as the dominant limitation for silica microcavity Q factors. Through laser polishing and thermal annealing, a record-high Q of 8.28 × 10⁹ is achieved, enabling fully stabilized soliton microcombs with >60.6 dB repetition-rate phase-noise suppression.

Aqueous batteries have a short lifespan due to Al current collector corrosion and Li loss from side reactions on the anode. Here, the authors propose a prototype of self-prolonging aqueous Li-ion batteries by introducing hydrolyzation-type anodic additives to regulate Al corrosion-passivation.

Desmocollin 2 (DSC2) binds to the EBV glycoprotein H/glycoprotein L complex and allows for virus entry to epithelial cells, which could be blocked by DSC2-specific antibodies. DSC2 allowed for virus entry independent of Ephrin receptor A2.

Efficient electrochemical energy storage in Li-S batteries is hindered by sluggish sulfur redox reactions. Here, the authors propose a polyoxometalate/multilayer graphene composite as a bifunctional electrocatalyst for battery performance improvement.

The authors present a FeCl₃ cathode design that enables all-solid-state lithium-ion batteries with a favourable combination of low cost, improved safety and good performance.

Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.

Chromosome-level genome assemblies of migratory and desert locusts, coupled with epigenomic profiling of migratory locusts, reveal chromatin dynamics underlying polyphenism and X-linked dosage compensation following autosomal gene translocation.

The authors here report an ultrathin ionomer membrane as an artificial solid-electrolyte interphase filter that minimizes parasitic reactions and enables stable dendrite-free lithium plating-stripping cycles in a carbonate-based electrolyte. The protected anodes exhibit outstanding coulombic efficiencies at room and elevated (50 °C) temperatures.

The chemoselective hydrogenation of molecules containing multiple reducible groups using molecular hydrogen presents inherent challenges. Here, the authors synthesize a homoleptic gold nanocluster that demonstrates exceptional catalytic selectivity, activity, and yield for the hydrogenation of 4-nitroacetophenone in water under mild conditions.

This study leverages single-nucleus multiomics to map cellular senescence atlas in aging human skeletal muscle and uncovers potential targets and senotherapeutics for treating age-associated sarcopenia.

High-energy-density lithium metal batteries suffer from limited cycle life. Here the authors develop a homogeneous and mechanically stable solid–electrolyte interphase by using a trioxane-modulated electrolyte, thereby expanding battery cyclability.