Nature Search

Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma – a multicenter phase 2 trial (EPOC1802)

Bando et al. perform a phase II trial of atezolizumab monotherapy following platinum-based definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma and report a complete response rate of 42%.

Hideaki Bando
Shogo Kumagai
Takashi Kojima
ResearchOpen Access19 Feb 2025
Nature Cancer

Volume: 6, P: 445-459
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Checkpoint blockade is effective in only a subset of patients; therefore, biomarkers that can predict efficacy would be clinically highly valuable. Nishkawa and colleagues develop a biomarker based on PD-1 positivity of effector and regulatory T cells in the tumor microenvironment that accurately predicts the effectiveness of checkpoint blockade in patients.

Shogo Kumagai
Yosuke Togashi
Hiroyoshi Nishikawa
Research31 Aug 2020
Nature Immunology

Volume: 21, P: 1346-1358
Depletion of central memory CD8⁺ T cells might impede the antitumor therapeutic effect of Mogamulizumab

Elimination of regulatory T cells via the anti-CCR4 monoclonal antibody, mogamulizumab, is expected to augment anti-tumour immune response. Authors show here that although regulatory T cell targeting is successful, clinical improvement remains minimal in patients with solid tumours due to concomitant and unintended depletion of central memory CD8⁺ T cells.

Yuka Maeda
Hisashi Wada
Hiroyoshi Nishikawa
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-13
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Quantum transport evidence of Weyl fermions in an epitaxial ferromagnetic oxide

Despite various predictions, the evidence of Weyl fermions in oxide materials remains elusive. Here, the authors show evidence of Weyl fermions in quantum transport measurements in an epitaxial ferromagnetic oxide SrRuO₃.

Kosuke Takiguchi
Yuki K. Wakabayashi
Hideki Yamamoto
ResearchOpen Access09 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis

A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

Kazuo Kitagawa
Hisatomi Arima
Seigo Nakada
Research04 Mar 2022
Hypertension Research

Volume: 45, P: 591-601
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens

Yukie Kashima
Yosuke Togashi
Toshihiko Doi
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-11
Dominance of the residential sector in Chinese black carbon emissions as identified from downwind atmospheric observations during the COVID-19 pandemic

Yugo Kanaya
Kazuyo Yamaji
Zbigniew Klimont
ResearchOpen Access16 Dec 2021
Scientific Reports

Volume: 11, P: 1-10
Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Yuma Sakamoto
Takuaki Yamamoto
Shiro Ikegawa
ResearchOpen Access08 Nov 2017
Scientific Reports

Volume: 7, P: 1-12

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