Search

A Cu-Au-Ag medium-entropy alloy with Damascus-style hierarchical layers provides balanced strength–ductility combination, enabling greener and more mechanically reliable metallic materials for advanced electronic packaging.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

There is a growing demand for wearable electronics for sensing, but it is challenging to integrate in-situ logic computing methods. Here the authors report multi-layered printed fibers to integrate logic circuits for wearable sensors.

Helicity-overriding behaviour in supramolecular copolymers is reported by manipulating the energy landscape of chiral co-monomers, where one chiral monomer can override the intrinsic helical preference of another, even when present in the minority. This finding offers insights into asymmetry amplification in multicomponent supramolecular systems.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

The mode of action of the biological Dnd antiphage defence system to cleave foreign DNA was not known. Now the activities of Dnd protein complexes are revealed, and a mechanism to discriminate between self-DNA and invading DNA is proposed.

A genomic constraint map for the human genome constructed using data from 76,156 human genomes from the Genome Aggregation Database shows that non-coding constrained regions are enriched for regulatory elements and variants associated with complex diseases and traits.

A noble-metal-free triazatriangulenium photosensitizer captures CO₂ as carbamic acid to boost local concentration to increase reduction efficiency. It achieves 51% quantum yield for CO, and forms amides with 85% atom efficiency even in the absence of solvent.

Using JWST, more than 40 individual stars have been detected in a distant galaxy, dating back to when the Universe was only half of its current age. The stars appear to be red (super)giants that are magnified by factors of hundreds.

Here the authors combine 19 F NMR and femtosecond transient absorption to characterise the structural origin of the multiphasic quenching dynamics in various species of BLUF domains, highlighting the importance of the heterogeneous active-site H-bond network.

Using Zr-doped HfO2 and ultra-thin indium tin oxide, Li et al. develop flexible field-effect transistors with a memory window of 2.78 V and bending reliability to enable high-performance back-end-of-line compatible wearable devices.

Using a polymer stamp with a period arrangement of micro-posts on its surface and a high surface tension liquid, two-dimensional material films can be patterned and transferred on a large-scale with high yield.

An integrated experimental-computational approach evaluates the impact of de novo missense mutations on protein–protein interactions. This interactome-based framework can be used to identify and prioritize disease-associated missense mutations.

Neddylation inhibition has been reported as a therapy for cancer. Here, the authors show that neddylation inhibition increases glutamine metabolism by stabilizing glutamine transporter ASCT2, therefore targeting ASCT2 improves the anti-cancer effect of neddylation inhibitors.

Base editing technology has great potential in treating pathogenic single-nucleotide variations. Using a dual-AAV base editing system, Wu et al. restored visual functions in a mouse model of retinitis pigmentosa.

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Exercise has beneficial effects on cognition. Here, authors utilize an exercise model to show ACVR1C to be an essential bidirectional regulator of memory and synaptic plasticity in adult, aging and 5xFAD mice beyond the context of exercise.

Sun, Fu, Zheng, Hong, Liu et al. generate a single-nucleus transcriptomic atlas of the primate cochlear aging, identifying an age-related decline in Slc35f1 and showing that silencing Slc35f1 in mice induces hair cell degeneration and auditory deficits.

Developing non-noble-metal heterogeneous catalysts with high efficiency in HCOOH dehydrogenation is significant for the acquisition of hydrogen, but remains a great challenge. Here, the authors modulate oxygen coverage of Ti₃C₂T_x MXenes to boost the catalytic activity toward HCOOH dehydrogenation.

Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.

Hepatocellular carcinoma can arise from hepatitis as a consequence of persistent inflammation. Here, Yang et al.show that the protein G-protein-coupled receptor adaptor β-arrestin1 promotes hepatocellular carcinogenesis through pro-inflammatory Akt signalling.

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

A strategy for inferring phase for rare variant pairs is applied to exome sequencing data for 125,748 individuals from the Genome Aggregation Database (gnomAD). This resource will aid interpretation of rare co-occurring variants in the context of recessive disease.

Here the authors show a beta alumina nanowires/gel polymer composite electrolyte design. The dense and homogeneous solid-liquid hybrid sodium-ion transportation channels promote uniform sodium deposition and stripping and significantly improve the performance of a Na metal battery.

Ferromagnetism with a Curie temperature above room temperature in 2D materials is highly desirable for practical spintronics applications. Here, the authors demonstrate such phenomenon in monolayer MoS₂ via in situ iron-doping and measured local magnetic field strength up to 0.5 ± 0.1 mT.

Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.

In this Tutorial, the authors provide guidelines for quality control of whole-exome and whole-genome sequencing data for population-scale association analyses. They explain how to filter samples and variants, and compare commonly used software programs for quality control of sequencing data.

Chen, Alhassen et al. show that schizophrenia-like behavioral deficits induced by excessive prenatal methionine administration are due to in-uterus aberrations rather than through early life mother-infant interaction in mice. This study identifies the brain metabolites and transcriptomic signatures, which potentially serve as early biomarkers for schizophrenia-like behaviors.

Aquatic ecological network stability of the plankton community declined substantially in the mid-1990s in response to climate warming and nutrient enrichment, according to a sedimentary DNA analysis in Lake Chagan, China coupled with planktonic network models.