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Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

The underlying formation mechanism and evolution of the ferroelectric phase in hafnium dioxide-based crystals is under debate. Here, the authors characterize the phase transitions and reveal the accompanying atomic movements in a co-doped crystal.

In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

The authors achieve piezoelectric coefficient d₃₃ ∼ 807 pC·N⁻¹, along with high k₃₃ ∼ 88 % and T_c ∼ 245 °C in (K,Na)(Nb_1-xSb_x)O₃-Bi_0.5Na_0.5ZrO₃-BiFeO₃ system through structural flexibility and grain orientation strategies.

By an alteration of dipoles and a phase transition, the authors find a giant electromechanical strain triggered by the electric current in thin antipolar Ag2Se semiconductor. The strain has inherent flexibility and conductivity.

The authors propose a design strategy for lead-free relaxors, characterized by a heterogeneous structure that is constructed through a multi-scale process, resulting in high energy storage performance.

This study reports that incorporating non-polar nanodomains into antiferroelectrics greatly enhanced the energy density and efficiency.

The authors realize a high piezoelectric charge coefficient in a self-poled ferroelectric film, addressing the persistent challenge of piezoelectric property degradation during industrial packaging and shaping the landscape of commercial ferroelectrics for micro-electro-mechanical systems.

Obesity arises from an imbalance between adipogenesis and adipocyte thermogenesis. IL-27 suppresses adipogenesis, prevents weight gain, and improves glucose and lipid metabolic homeostasis in high-fat diet obese mice.

This study uses available models to show intensified Atlantic multidecadal variability under global warming. Warmer and fresher waters, along with slowed overturning circulation, reduce the mixed layer, intensifying sea surface temperature variability, suggesting increased global climate extremes.

The authors utilize a high-entropy design strategy to enhance the high-temperature energy storage capabilities of BaTiO₃-based ceramic capacitors, realizing energy storage performance from −50 °C to 260 °C and maintaining functionality after one million charge-discharge cycles at 200 °C.

Macromolecules with antimicrobial properties are promising materials for combating multi-drug-resistant microbes. Now, it has been shown that amphiphilic cationic polycarbonates that are biodegradable can self-assemble into micellar nanoparticles that can kill gram-positive bacteria, MRSA and fungi efficiently, even at low concentrations. Moreover, no significant toxicity is observed during in vivo studies in mice.

Grain alignment and polarization engineering were simultaneously utilized to enhance the energy storage performance of Na_1/2Bi_1/2TiO₃-based multilayer ceramic capacitors, leading to an energy density of 15.7 J·cm⁻³ and energy efficiency over 95%.

The authors improve the energy storage performance and high temperature stability of lead-free tetragonal tungsten bronze dielectric ceramics through high entropy strategy and band gap engineering.

Macrophages are considered a good candidate for cancer cytotherapy because of their phagocytotic capacity, enabling them to deliver cargo to tissues. Here authors engineer macrophages that are targeted to glypican-3-expressing tumour cells and equipped with drug-loaded exosomes and show therapeutic efficiency in a mouse model of hepatocellular cancer.

In a prespecified interim analysis of the phase 3 trial GEMSTONE-304, anti-PD-L1 with chemotherapy versus chemotherapy alone led to significantly prolonged progression-free survival and overall survival of patients with unresectable, locally advanced, recurrent or metastatic esophageal squamous cell carcinoma.

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

Here, the authors report results from a randomized, placebo-controlled phase 3 trial of the tetravalent SARS-CoV-2 protein vaccine SCTV01E, demonstrating a favorable efficacy profile during a time when predominant viral variants were changing from BA.5 and BF.7 to XBB.

For relaxor ferroelectrics, correlating their properties and local structures is challenging. Here, the authors correlate the atomic-scale structure and the large dynamic electromechanical property in Bi_0.5Na_0.5TiO₃-based relaxor ferroelectrics.

Electrostatic capacitors can enable ultrafast energy storage and release, but advances in energy density and efficiency need to be made. Here, by doping equimolar Zr, Hf and Sn into Bi₄Ti₃O₁₂ thin films, a high-entropy stabilized Bi₂Ti₂O₇ pyrochlore phase forms with an energy density of 182 J cm⁻³ and 78% efficiency.

Zhang, Hou, Ma et al. present PROFIT-seq, a sequencing strategy that involves adaptive sampling of transcriptome libraries to enrich genes of interest and allows unbiased quantification of the whole transcriptome.

The nanoparticle-polymer interface plays a key role in nanoparticle-polymer composites but understanding the structures and properties of the interfacial region remains challenging. Here, the authors directly observe the presence of two interfacial polymer layers around a nanoparticle in polar polymers with different polar molecular conformations from the bulk polymer leading to an enhancement in polarity-related properties of polymer nanocomposites

Piezoelectric biomaterials are limited by the challenges in domain orientation alignment and a weak piezoelectric effect. Here, Zhang et. al. present an active self-assembly strategy via nanoconfinement and in-situ poling, to obtain large-scale, high performance piezoelectric β-glycine nanocrystalline films.

Combining a perovskite ferroelectric with moderate piezoelectric properties and a nonpiezoelectric pervoskite relaxor can create a highly piezoelectric material. Here, the authors help explain this unusual result by quantifying how polar nanoregions in the material contribute to its piezoelectric response.

The tumour lymph node microenvironment is an important contributor to the immune suppressiveness of tumours. Here authors target the tumours and the lymph node simultaneously via a pH and photothermal therapy targeted nanoparticle, and show mobilisation of anti-tumour cytotoxic T cells and NK cells and synergistic therapeutic effect with immune checkpoint blockade.

The energy density of dielectric ceramic capacitors is limited by low breakdown fields. Here, by considering the anisotropy of electrostriction in perovskites, it is shown that <111>-textured Na_0.5Bi_0.5TiO₃–Sr_0.7Bi_0.2TiO₃ ceramics can sustain higher electrical fields and achieve an energy density of 21.5 J cm⁻³.

We successfully rebuild an approximate void-free additive manufacturing microstructure in Ti-6Al-4V titanium alloy by the development of a void-free additive manufacturing processing technique through an understanding of the asynchronism of phase transformation and grain growth.

Some patients present with multiple lung tumours but it is unclear whether these are metastases or individual lesions. Here, the authors use genomics techniques to demonstrate in six patients that multiple tumours have individual genetic profiles and represent separate tumours.

Human genome sequences have so far been reported for individuals with ancestry in three distinct geographical regions: a Yoruba African, two individuals of northwest European origin, and a person from China. Here, using a combination of methods, a highly annotated, whole-genome sequence is provided for a Korean male.

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.

Antibiotic resistance is a major threat across the whole healthcare spectrum. Here, the authors report on the development of biodegradable guanidinium functionalized polycarbonates and demonstrate antimicrobial activity against drug resistant infections.

In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors.

The role of long non-coding RNA (lncRNA) in AKT-driven tumor development is unclear. Here, the authors identify VAL (Vimentin associated lncRNA) to be directly induced by AKT/STAT3 signaling and report a lncRNA-mediated mechanism for active AKT-driven EMT-independent lung adenocarcinoma metastasis.

Under global warming, increased variability in El Niño sea surface temperature was projected to be detectable by about 2070. Here the authors show that the increased variability of a type of more impactful El Niño events is likely detectable by 2030.

Converting natural wood to room temperature phosphorescent (RTP) materials is a complex process often requiring toxic reagents. Here the authors convert natural wood to a RTP material using external chloride ions from a MgCl2 solution, obtaining a promising luminescent additive material for 3D printing.

Invasion of the gut by oral bacteria in liver cirrhosis.

Only a few relaxors can be grown into crystals, which show high piezoelectricity, but their operable temperature range is limited by the low phase transition temperature. Here, the authors develop an approach to fabricate textured relaxor ceramics with elevated phase transition temperatures.

The Review discusses the state-of-the-art polymer nanocomposites from three key aspects: dipole activity, breakdown resistance and heat tolerance for capacitive energy storage applications.