Nature Search

UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing

UDA-seq incorporates a post-indexing step to enhance the throughput of droplet-based single-cell multimodal sequencing, enabling efficient large-scale single-cell analysis.

Yun Li
Zheng Huang
Lan Jiang
ResearchOpen Access20 Jan 2025
Nature Methods

P: 1-14
Single-cell EpiChem jointly measures drug–chromatin binding and multimodal epigenome

EpiChem enables the co-profiling of small molecule–DNA interactions and multiple epigenomic features in single cells.

Chao Dong
Xiaoxuan Meng
Aibin He
ResearchOpen Access18 Jul 2024
Nature Methods

Volume: 21, P: 1624-1633
The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium

Crosstalk between tumor cells and the microenvironment is essential for tumor progression. Here, the authors show Pancreatic ductal adenocarcinoma (PDAC) epithelial cells with high level of Lin28b secrete Wnt5a to upregulate Lin28b expression in cancer-associated fibroblasts, which in turn promote growth of PDAC cells via production of PCSK9.

Zhaoqi Shu
Minghe Fan
Ying Zhao
ResearchOpen Access28 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Fertilizer management for global ammonia emission reduction

A machine learning model for generating crop-specific and spatially explicit NH₃ emission factors globally shows that global NH₃ emissions in 2018 were lower than previous estimates that did not fully consider fertilizer management practices.

Peng Xu
Geng Li
Benjamin Z. Houlton
Research31 Jan 2024
Nature

Volume: 626, P: 792-798
Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Michalina Janiszewska
Doris P. Tabassum
Kornelia Polyak
Amendments and Corrections05 Mar 2024
Nature Cell Biology

Volume: 26, P: 841
De novo genes with an lncRNA origin encode unique human brain developmental functionality

Studying human-specific de novo genes originated from long non-coding RNA, the authors reveal molecular mechanisms that facilitate nuclear export of these young genes, and show experimental evidence for the role of one such gene in brain development.

Ni A. An
Jie Zhang
Chuan-Yun Li
ResearchOpen Access02 Jan 2023
Nature Ecology & Evolution

Volume: 7, P: 264-278
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

Effective combination therapies to improve the efficacy of BET inhibitors are currently under investigation. Here, the authors examine palbociclib and paclitaxel as two promising candidates for combination therapies with BET inhibition in breast cancer and investigate the dynamics of resistance to these combinations through DNA barcoding and mathematical modelling.

Jennifer Y. Ge
Shaokun Shu
Kornelia Polyak
ResearchOpen Access11 May 2020
Nature Communications

Volume: 11, P: 1-17
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils.

Michalina Janiszewska
Doris P. Tabassum
Kornelia Polyak
Research01 Jul 2019
Nature Cell Biology

Volume: 21, P: 879-888
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

BET inhibitors that target bromodomain chromatin readers such as BRD4 are being explored as potential therapeutics in cancer; here triple-negative breast cancer cell lines are shown to respond to BET inhibitors and resistance seems to be associated with transcriptional changes rather than drug efflux and mutations, opening potential avenues to improve clinical responses to BET inhibitors.

Shaokun Shu
Charles Y. Lin
Kornelia Polyak
Research06 Jan 2016
Nature

Volume: 529, P: 413-417

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