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Showing 1–2 of 2 results
Advanced filters: Author: Shannon D Chilewski Clear advanced filters

  • Steven McCarroll and colleagues examine common gene deletions in individuals that have undergone bone marrow transplantation. They find that risk of acute graft-versus-host disease is greater when the donor and recipient are mismatched for a homozygous deletion of UGT2B17.

    • Steven A McCarroll
    • James E Bradner
    • David Altshuler
    Research
    Nature Genetics
    Volume: 41, P: 1341-1344

  • Mark Daly, Ramnik Xavier and colleagues report that a 20-kb deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn's disease. They also show that manipulation of IRGM levels in cells modulated the efficiency of autophagic responses to internalized bacteria, suggesting a mechanism by which the deletion variant might influence disease risk.

    • Steven A McCarroll
    • Alan Huett
    • Ramnik J Xavier
    Research
    Nature Genetics
    Volume: 40, P: 1107-1112