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Showing 1–5 of 5 results
Advanced filters: Author: Satoshi Kakugawa Clear advanced filters

  • The biochemical activity of Notum as a carboxylesterase that removes an essential lipid moiety from Wnt proteins is uncovered; the interaction of Notum with glypicans is required to ensure localization at the cell surface, and Notum may provide a new target for therapeutic development in diseases with defective Wnt signalling.

    • Satoshi Kakugawa
    • Paul F. Langton
    • Jean-Paul Vincent
    Research
    Nature
    Volume: 519, P: 187-192

  • CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

    • Satoshi Kojo
    • Hirokazu Tanaka
    • Ichiro Taniuchi
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • On 11 June 2009 the World Health Organization declared that the infections caused by a new strain of influenza A virus closely related to swine viruses had reached pandemic levels. Here, one of the first US isolates of the new swine-origin H1N1 influenza virus (S-OIV) is characterized, as well as several other S-OIV isolates, both in vitro and in vivo.

    • Yasushi Itoh
    • Kyoko Shinya
    • Yoshihiro Kawaoka
    Research
    Nature
    Volume: 460, P: 1021-1025