Nature Search

Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

P: 1-21
Author Correction: Lake ice quality in a warming world

Joshua Culpepper
Ellinor Jakobsson
Sapna Sharma
Amendments and Corrections30 Sept 2024
Nature Reviews Earth & Environment

Volume: 5, P: 906
Long-term ice phenology records spanning up to 578 years for 78 lakes around the Northern Hemisphere

Sapna Sharma
Alessandro Filazzola
John J. Magnuson
ResearchOpen Access16 Jun 2022
Scientific Data

Volume: 9, P: 1-15
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Alice Williamson
Dougall M. Norris
Claudia Langenberg
Research08 Jun 2023
Nature Genetics

Volume: 55, P: 973-983
Widespread loss of lake ice around the Northern Hemisphere in a warming world

Up to 35,000 lakes in the Northern Hemisphere may be at risk of intermittent winter ice cover at 2 °C warming, reveals an observation-based study. This would affect 394 million people reliant on lake ice for ecosystem services.

Sapna Sharma
Kevin Blagrave
R. Iestyn Woolway
Research28 Jan 2019
Nature Climate Change

Volume: 9, P: 227-231
Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Blood circulating proteins reflect biological processes, thus providing insight into complex traits. Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.

Shaza B. Zaghlool
Sapna Sharma
Karsten Suhre
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-13
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

A candidate vaccine against SARS-CoV-2 that uses the yellow fever 17D live-virus vector is highly efficacious and displays a favourable safety profile in Syrian hamster, mouse and cynomolgus macaque models.

Lorena Sanchez-Felipe
Thomas Vercruysse
Kai Dallmeier
Research01 Dec 2020
Nature

Volume: 590, P: 320-325
Neoadjuvant relatlimab and nivolumab in resectable melanoma

Patients with resectable clinical stage III or oligometastatic stage IV melanoma were given neoadjuvant relatlimab and nivolumab combination immunotherapy, which induced a high pathologic complete response rate, indicating the efficacy and safety of this regimen.

Rodabe N. Amaria
Michael Postow
Hussein A. Tawbi
ResearchOpen Access26 Oct 2022
Nature

Volume: 611, P: 155-160
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Andrew A. Brown
Juan J. Fernandez-Tajes
Ana Viñuela
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 399-408
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Currently licensed COVID-19 vaccines are based on antigen sequences of early SARS-CoV-2 isolates, despite the prevalence of variants of concerns escaping vaccine-mediated protection. Using their updated yellow fever 17D vectored candidate, here, authors assess neutralising antibody responses against variants of concern, and demonstrate protection and reduced transmission in a hamster model.

Sapna Sharma
Thomas Vercruysse
Kai Dallmeier
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-11
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.

Robbert Boudewijns
Hendrik Jan Thibaut
Kai Dallmeier
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Impact of delay in early swallow screening on pneumonia, length of stay in hospital, disability and mortality in acute stroke patients

Thang S Han
Michael EJ Lean
Pankaj Sharma
Research27 Mar 2018
European Journal of Clinical Nutrition

Volume: 72, P: 1548-1554
B cells and tertiary lymphoid structures promote immunotherapy response

Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.

Beth A. Helmink
Sangeetha M. Reddy
Jennifer A. Wargo
Research15 Jan 2020
Nature

Volume: 577, P: 549-555
Identification and biophysical characterization of potential phytochemical inhibitors of carboxyl/choline esterase from Helicoverpa armigera for advancing integrated pest management strategies

Harry Kaur
Simranjeet Singh
Nadeem A. Khan
ResearchOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: Neoadjuvant relatlimab and nivolumab in resectable melanoma

Rodabe N. Amaria
Michael Postow
Hussein A. Tawbi
Amendments and CorrectionsOpen Access09 Mar 2023
Nature

Volume: 615, P: E23
Towards critical white ice conditions in lakes under global warming

Under continued global warming, lakes will increasingly be covered by white ice, in particular towards the end of the ice cover season when fatal winter drownings occur most often and light limits the growth and reproduction of primary producers.

Gesa A. Weyhenmeyer
Ulrike Obertegger
Roman Zdorovennov
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-8
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

In a multicenter research program coordinated by the International Mouse Phenotyping Consortium, Spielmann et al. analyze the cardiac function and structure in ~4,000 monogenic mutant mice and identify 705 mouse genes involved in cardiac function, 75% of which have not been previously linked to cardiac heritable disease in humans. Using the UK Biobank human data, the authors validate the link between cardiovascular disease and some of the newly identified genes to illustrate the resource value and potential of their mutant mouse collection.

Nadine Spielmann
Gregor Miller
Martin Hrabe de Angelis
ResearchOpen Access17 Feb 2022
Nature Cardiovascular Research

Volume: 1, P: 157-173
Phenological shifts in lake stratification under climate change

Stratification has a considerable influence on lake ecology, but there is little understanding of past or future changes in its seasonality. Here, the authors use modelling and empirical data to determine that between 1901–2099, climate change causes stratification to start earlier and end later.

R. Iestyn Woolway
Sapna Sharma
Eleanor Jennings
ResearchOpen Access19 Apr 2021
Nature Communications

Volume: 12, P: 1-11
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Clinical benefit or intestinal toxicity resulting from combined immune checkpoint blockade in patients with melanoma associates with prevalent commensal bacteria and can be decoupled by IL-1R inhibition.

Miles C. Andrews
Connie P. M. Duong
Jennifer A. Wargo
Research08 Jul 2021
Nature Medicine

Volume: 27, P: 1432-1441
Author Correction: Towards critical white ice conditions in lakes under global warming

Gesa A. Weyhenmeyer
Ulrike Obertegger
Roman Zdorovennov
Amendments and CorrectionsOpen Access06 Jun 2023
Nature Communications

Volume: 14, P: 1
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

Jan Rozman
Birgit Rathkolb
Martin Hrabe de Angelis
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-16
Purification and biological analysis of antimicrobial compound produced by an endophytic Streptomyces sp.

Sapna Devi
Manish Sharma
Rajesh Kumari Manhas
ResearchOpen Access14 Sept 2023
Scientific Reports

Volume: 13, P: 1-14
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026
Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Rodabe N. Amaria
Sangeetha M. Reddy
Jennifer A. Wargo
Amendments and Corrections25 Oct 2018
Nature Medicine

Volume: 24, P: 1941
Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Rodabe N. Amaria
Sangeetha M. Reddy
Jennifer A. Wargo
Amendments and Corrections25 Oct 2018
Nature Medicine

Volume: 24, P: 1942
Direct observations of ice seasonality reveal changes in climate over the past 320–570 years

Sapna Sharma
John J. Magnuson
Yasuyuki Aono
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

Nadine Spielmann
Gregor Miller
Martin Hrabe de Angelis
Amendments and CorrectionsOpen Access20 Apr 2022
Nature Cardiovascular Research

Volume: 1, P: 529-531
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
Global lake responses to climate change

Climate change affects lakes worldwide and is predicted to continue to alter lake ice cover, surface temperature, evaporation rates, water levels and mixing regimes. This Review discusses recent and expected lake responses to climate change and looks towards future research opportunities in lake monitoring and modelling.

R. Iestyn Woolway
Benjamin M. Kraemer
Sapna Sharma
Reviews14 Jul 2020
Nature Reviews Earth & Environment

Volume: 1, P: 388-403
Lake ice quality in a warming world

Lake ice has witnessed considerable changes in its phenology, but less is known about ice quality — the ratio of black ice to white ice. This Review assesses the changes in lake ice quality and its ecosystem services, noting diminished ice quality in observations and projections.

Joshua Culpepper
Ellinor Jakobsson
Sapna Sharma
Reviews19 Sept 2024
Nature Reviews Earth & Environment

Volume: 5, P: 671-685
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Neoadjuvant combination treatment with nivolumab and ipilimumab in patients with high-risk melanoma results in higher response rates than nivolumab monotherapy and warrants future optimization of dosing regimens to preserve efficacy while limiting toxicity.

Rodabe N. Amaria
Sangeetha M. Reddy
Jennifer A. Wargo
Research08 Oct 2018
Nature Medicine

Volume: 24, P: 1649-1654
Author Correction: Long-term ice phenology records spanning up to 578 years for 78 lakes around the Northern Hemisphere

Sapna Sharma
Alessandro Filazzola
John J. Magnuson
Amendments and CorrectionsOpen Access18 Jul 2022
Scientific Data

Volume: 9, P: 1
A global database of lake surface temperatures collected by in situ and satellite methods from 1985–2009

Sapna Sharma
Derek K Gray
Kara H Woo
ResearchOpen Access17 Mar 2015
Scientific Data

Volume: 2, P: 1-19
Delivering hypertension care in private-sector clinics of urban slum areas of India: the Mumbai Hypertension Project

Asha Hegde
Haresh Patel
Shibu Vijayan
ResearchOpen Access24 Sept 2022
Journal of Human Hypertension

Volume: 37, P: 767-774
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

Susanne Jäger
Simone Wahl
Karina Meidtner
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-12
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

Alexandre Reuben
Christine N. Spencer
Jennifer A. Wargo
ResearchOpen Access07 Apr 2017
npj Genomic Medicine

Volume: 2, P: 1-11
DOCU-CLIM: A global documentary climate dataset for climate reconstructions

Angela-Maria Burgdorf
Stefan Brönnimann
Inmaculada Vega
ResearchOpen Access23 Jun 2023
Scientific Data

Volume: 10, P: 1-14
A database of chlorophyll and water chemistry in freshwater lakes

Alessandro Filazzola
Octavia Mahdiyan
Sapna Sharma
ResearchOpen Access22 Sept 2020
Scientific Data

Volume: 7, P: 1-10

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