Various molecules, such as components of the slit diaphragm and the glomerular basement membrane strictly orchestrate the integrity of the glomerular filtration barrier. Genetic defects in these components have the potential to cause glomerular disease. In this Review, Chiang and Inagi summarize genetic abnormalities that affect the structural and functional integrity of the glomerulus. The authors also discuss some of the therapeutic avenues that are being explored for the treatment of genetic forms of glomerular disease.
- Chih-Kang Chiang
- Reiko Inagi
