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Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia/reperfusion injury.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

The authors reveal a complex polarization network in twisted bilayer h-BN, featuring edge polarization topology and sliding ferroelectricity, driven by the interplay of ferroelectric and piezoelectric effects.

Here, the authors identify SPIN1 as a member of the subcortical maternal complex (SCMC). The SCMC component FILIA protects H3K4me3 reprogramming and zygotic genome initiation by preventing nuclear entry of SPIN1.

Rapid temperature flips between hot and cold extremes will become more frequent, more intense, and more rapid globally by the end of the twenty-first century, which is exacerbated in world’s breadbasket regions and low-income countries.

Efficient charge separation plays a crucial role in enhancing artificial photocatalysis. Here, the authors report an alkali etching method to construct an electron transfer layer on BiVO₄:Mo photocatalysts, leading to a charge separation efficiency exceeding 90% at 420 nm.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

A pangenome of wild and cultivated rice accessions captures the entire set of non-redundant genes and diversity in rice, and provides insights into the pathways involved in the evolution of rice.

Bioproduction of steroids involves NADPH-dependent enzymes that mediate electron transfer reactions. Here, the author reveal the electron transfer mechanisms of NADPH-dependent enzymes and demonstrate the complete biosynthesis of steroids through electron transfer engineering.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

The authors achieve piezoelectric coefficient d₃₃ ∼ 807 pC·N⁻¹, along with high k₃₃ ∼ 88 % and T_c ∼ 245 °C in (K,Na)(Nb_1-xSb_x)O₃-Bi_0.5Na_0.5ZrO₃-BiFeO₃ system through structural flexibility and grain orientation strategies.

Organic semiconductors suffer from low optical damage thresholds, limiting their use in applications. Here the authors bypass this limit by utilizing spectrally tailored gain from stimulated emission to amplify molecular vibrations in organic semiconductors for efficient Raman lasers.

Circular RNA aptamers dampen Alzheimer disease phenotypes in mouse models

This study reveals a regulation mechanism of the ALR1 aluminium receptor involving phosphorylation switching by PP2C phosphatases and PBL27 kinase. This mechanism modulates ALR1–BAK1 complex formation, thereby controlling plant aluminium sensing and resistance.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Integrated analysis of metabolome and oxidative stress at single-cell level is challenging. Here, the authors develop SCLIMS, enabling simultaneous profiling of metabolome and oxidative stress levels and discoveries of key metabolites regulating oxidative stress, senescence, and healthy aging.

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

The authors report a vacancy engineering method to simultaneously optimize carrier concentration and maintain high plasticity, achieving a nearly 10% strain in three-point bending tests and a high ZT of ~0.83 at 343 K in (AgCu)0.998Te0.8Se0.1S0.1.

This work achieves a flexible organic ferroelectric crystal with interesting plasticity by implementing fluorination on anion, making it a competitive candidate for flexible and wearable devices.

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce ALS-like phenotypes in rats and highlight CIV deficiency as a potential risk factor and therapeutic target for ALS.

Xiao et al. report that adoptively transferred tumor-specific CD8⁺ interleukin-9-producing cytotoxic T cells promote the recruitment and activation of host effector CD4⁺ T cells to control the outgrowth of tumors with antigen loss.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

Parvimonas micra (P. micra) is an oral opportunistic pathogen frequently present in oral lesions and infections. Here, authors report that P. micra promotes oral squamous cell carcinoma metastasis by regulation HIF-1α-induced glycolysis and autophagy following TmpC protein binding to CKAP4 receptor.

Here, the authors present multi-ancestry genome-wide meta-analyses of uterine fibroids, identifying 11 new gene associations, and demonstrating that heritability is higher in African ancestries.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Attempts to extend the range of reversible intercalation stoichiometries in selenides are promising but challenging. Here, authors report a reversible controlled superstoichiometric intercalation in NbSe₂ with up to two copper-ions per molecule by triggering anionic redox.

The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. Here, the authors report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with internal alkynes via photoredox and cobalt dual catalysis.

Here, the authors fabricate hybrid van der Waals heterostructures based on 2D tessellations of DNA origami thin films, graphene and boron nitride, showing that the DNA films can induce periodic superlattices at the interface and modulate the electronic properties of the samples.

Developing soft conductive gels for epidermal electronics is a challenge: Here, the authors introduced a liquid-to-solid transformation concept to improve biointerface integration.

Reactivating adult cardiomyocyte proliferation is key to heart regeneration post-injury. Here, authors show that medium from human iPSC-derived primitive macrophages (hiPM-cm) induces adult cardiomyocyte proliferation and promotes heart regeneration.

This study reveals that RNA silencing component Argonaute 2 (AGO2) loads small RNAs at endoplasmic reticulum–chloroplast membrane contact sites with the help of RNA helicase 3 (RH3), which also enhances the loading of viral-derived small RNAs. These findings highlight the connections between RNA silencing, viral replication, and plant antiviral resistance.

One effector of wheat disease pathogen is found to prevent the entry of thioredoxin into chloroplast. This disrupts the thioredoxin-mediated monomerization of STAYGREEN, a key regulator of senescence, and thereby suppresses plant defense responses.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

A haplotype-resolved genome of hybrid sugarcane cultivar XTT22 and population analyses of Saccharum accessions highlight the genome evolution of allopolyploids and provide opportunities for sugarcane breeding.

Using single-molecule force spectroscopy, the authors demonstrate that proline isomerization and cysteine-mediated disulfide bonds lead to distinct mechanical states of the titin I-band immunoglobulin-like domains within the physiological force range.

Endovascular thrombectomy (EVT) achieves high recanalization rates in acute stroke, but many patients still experience poor outcomes. Here, the authors show that intravenous edaravone dexborneol (ED) is safe and reduces early hemorrhage but does not significantly improve 90-day functional outcomes in stroke patients after EVT.

Ambient-pressure superconductivity onset above the McMillan limit in bilayer nickelate epitaxial thin films is reported, paving the way for comprehensive investigations of superconductors and for exploring superconductivity at higher transition temperatures in heterostructures.

Near-edge plasma treatment of Hf0.5Zr0.5O2 capacitors results in dielectric permittivity of 921, stored charge density of 349 μC/cm2, and energy density of 584 J/cm3 when the material’s ferroelectricity abruptly disappears after polarization fatigue.