Nature Search

Ligand-based design of [¹⁸F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

[¹⁸F]OXD-2314 is a brain penetrant positron emission tomography radiotracer with high affinity for tau aggregates in Alzheimer’s disease (AD) and non-AD tauopathies based on in vitro and in vivo studies, and is suitable for first-in-human use.

Anton Lindberg
Emily Murrell
Neil Vasdev
ResearchOpen Access14 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge

Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital pathology.

Wouter Bulten
Kimmo Kartasalo
Jeonghyuk Park
ResearchOpen Access13 Jan 2022
Nature Medicine

Volume: 28, P: 154-163
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists

Wouter Bulten
Maschenka Balkenhol
Geert Litjens
ResearchOpen Access05 Aug 2020
Modern Pathology

Volume: 34, P: 660-671
Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs

Paola M.C. Lembo
Eric Grazzini
Sultan Ahmad
Research19 Feb 2002
Nature Neuroscience

Volume: 5, P: 201-209
An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading

Yuri Tolkach
Vlado Ovtcharov
Reinhard Buettner
ResearchOpen Access15 Aug 2023
npj Precision Oncology

Volume: 7, P: 1-9
Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues

Denis Filisetti
Georg Ostermann
Claudine Oudet
Research22 Jun 1999
European Journal of Human Genetics

Volume: 7, P: 615-619
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase

Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses in aged AHKO mice, possibly due to blunted lipolytic activity in adipose tissue with pronounced lipodystrophy.

Laura Pajed
Ulrike Taschler
Gabriele Schoiswohl
ResearchOpen Access10 Mar 2021
Communications Biology

Volume: 4, P: 1-13
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Cultured human embryonic stem cells often acquire chromosomal abnormalities that could be detrimental in certain applications. Närvä et al. report the highest-resolution genetic analysis of these cells to date and identify genes whose expression is altered by culture-induced genetic changes.

Elisa Närvä
Reija Autio
Riitta Lahesmaa
Research28 Mar 2010
Nature Biotechnology

Volume: 28, P: 371-377
Effects of changing farming practices in African agriculture

Todd S. Rosenstock
Peter Steward
Katherine Tully
ResearchOpen Access03 Sept 2024
Scientific Data

Volume: 11, P: 1-8
Artificial intelligence and the future of the internal audit function

Fekadu Agmas Wassie
László Péter Lakatos
ReviewsOpen Access11 Mar 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Field induced crossover in critical behaviour and direct measurement of the magnetocaloric properties of La_0.4Pr_0.3Ca_0.1Sr_0.2MnO₃

Sagar Ghorai
Ridha Skini
Peter Svedlindh
ResearchOpen Access10 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

Kristoffer Ström
David Morales-Alamo
Ola Hansson
ResearchOpen Access14 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models

Carlos Martínez-Pérez
Carol Ward
Simon P Langdon
ResearchOpen Access31 Mar 2016
British Journal of Cancer

Volume: 114, P: 905-916
Micromechanics of ultra-toughened electrospun PMMA/PEO fibres as revealed by in-situ tensile testing in an electron microscope

Richard L. Andersson
Valter Ström
Richard T. Olsson
ResearchOpen Access11 Sept 2014
Scientific Reports

Volume: 4, P: 1-8
The importance of study design in the application of artificial intelligence methods in medicine

Martin Eklund
Kimmo Kartasalo
Peter Ström
CorrespondenceOpen Access18 Oct 2019
npj Digital Medicine

Volume: 2, P: 1-2

Search

Ligand-based design of [¹⁸F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge

Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists

Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs

An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading

Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues

Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Effects of changing farming practices in African agriculture

Artificial intelligence and the future of the internal audit function

Field induced crossover in critical behaviour and direct measurement of the magnetocaloric properties of La_0.4Pr_0.3Ca_0.1Sr_0.2MnO₃

N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models

Micromechanics of ultra-toughened electrospun PMMA/PEO fibres as revealed by in-situ tensile testing in an electron microscope

The importance of study design in the application of artificial intelligence methods in medicine

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