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Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Continuous shape morphing for small robots can offer advantages, but it is difficult to perform tasks if they are not stiff enough. Xu et al. present here a design combining liquid crystal elastomers and shape memory polymers to lock morphable elements in place.

Accurate separation of radioactive ⁹⁰Sr from groundwater or seawater remains a challenge in environmental radioactivity remediation. Here, the authors mimic the complexation behavior of molecular crown-ether carboxylic acids to construct a supramolecular trap in an anionic crown ether-based metal-organic framework for precisely catching Sr²⁺.

Many sporadic cases of hypertrophic cardiomyopathy have unknown genetic basis. Here, the authors identify a mutation in the gene NAP1L1 to be associated with cases of hypertrophic cardiomyopathy, linking it to cGAS-STING-IFN signaling.

Catalysts synthesized by current methods for CO₂ electroreduction to CO exhibit limited activity and selectivity over broad potentials. Here, the authors report an in situ etching method to create NiN₂ sites with uniform-large vacancies that achieve high activity across a wide potential window.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate targeting HER2 but paradoxically efficient even in breast cancers expressing HER2 at very low levels. Here authors show that invasive breast cancers, even if their HER2 expression is negligible, secrete extracellular proteases, such as cathepsin L, which cleave the specialized linker of T-DXd, releasing the drug in the tumour microenvironment, while in HER2 positive breast cancers, T-DXd engages Fcγ receptors to promote phagocytosis of HER2-expressing cells and triggers payload-induced immunogenic cell death.

The authors synthesize cubic GeSe through the alloying of the metavalent compound Sb₂Te₃ and vacancy engineering, achieving a record ZT of 1.38 at 723 K and an energy conversion efficiency of 6.13% in a single-leg thermoelectric device.

Evaluating the off-target effect is crucial for ensuring the safety of CRISPR–Cas9-based technologies. Duan, Gao and Zhang et al. developed TOPO-seq, a method to capture and evaluate DNA topology-regulated off-target activity of Cas9-based genome-editing tools.

Phylogenetic origin of the Y haplome present in allopolyploid Triticeae species is unclear. Here, the authors report the genome assembly of allohexaploid Elymus nutans, reveal the all likely combinations of St, Y, and H haplomes during the allopolyploid origins, and identify gene responsible for UV-B radiation adaptation.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Wearable thermoelectric devices are promising, though fabricating a breathable, sensitive, and washable devices has been a challenge. This report shows a woven thermoelectric fabric, incorporating rigid and flexible layers, for smart wearable devices.

Yang and colleagues present a small-molecule inhibitor for ADAR1 and show that its use is therapeutically beneficial in the context of prostate cancer.

The realization of efficient perovskite/organic tandem solar cells has been challenging due to large voltage deficits and severe non-radiative recombination. Here, the authors introduce sandwiched hole transport configuration for more balanced carrier transport, achieving efficiency of 26.05%.

Propane dehydrogenation is challenging to perform under mild conditions due to the reaction’s endothermic nature. Now, near-ambient propane dehydrogenation has been shown using copper single-atom catalysts supported on titanium oxide under light illumination and a water vapour environment.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

As a ‘safe’ alternative to harmful monomeric halogenated flame retardants, the use of polymeric flame retardants has surged in recent years. The authors show that polymeric flame retardants break down in the environment into small toxic molecules that can pose environmental hazards.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Spin-polarized light-emitting diodes (spin-LEDs) convert the electronic spin information to photon circular polarization, but they are usually controlled only by external magnetic fields. Here, the authors report the realization of spin-LEDs based on 2D CrI₃/hBN/WSe₂ heterostructures, showing electrical tunability of the electroluminescence helicity.

The authors report a vacancy engineering method to simultaneously optimize carrier concentration and maintain high plasticity, achieving a nearly 10% strain in three-point bending tests and a high ZT of ~0.83 at 343 K in (AgCu)0.998Te0.8Se0.1S0.1.

An isolation strategy is presented to improve the stability of metal nanoparticles by grafting oxide nano-islands between the support and the nanoparticles. This enhances sintering resistance, with the mean size of the nanoparticles maintained at 1.4 nm after 400 h of catalytic dry reforming of methane.

This study proposes an integrated sensing and communication (ISAC) scheme leveraging space-timecoding metasurfaces (STCMs), which enables concurrent wireless communication and sensing on a shared platform.

The transfer of nuclear chromatin to the cytoplasm drives the pro-aging inflammatory phenotype of senescent cells. Here, Miller et al. show that this process is suppressed by p53 and that activation of p53 reverses some features of aging in vivo.

Gestational diabetes milletus (GDM) may have impairments on offspring health. Here, the authors suggest that the increase of EZH2 is an important reason for the disrupted DNA methylome in oocytes exposed to GDM, which may be associated with the transgenerational inheritance of the metabolic disorders.

Recent advancements in biological technologies have enabled the measurement of spatially resolved multi-omics data. Here, the authors present COSMOS and demonstrate its superior performance compared to existing methods for integrating spatially resolved multi-omics data.

O3-type layered oxides are promising intercalative electrode materials for Na-ion batteries. Here, authors analyze the interlayer spacings of a family of oxides and propose an intrinsic structural parameter to serve as a measure of cycling stability.

RNA modifications like m6A are vital for gene expression but challenging to detect at single-base resolution. Here, the authors introduce pum6a, an advanced computational framework, to enable precise single-base m6A detection and uncovering regulatory mechanisms in hypoxic cancer cells.

Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARα-targeted microRNAs. They demonstrate the therapeutic potential of intervening in this process using the PPARα agonist fenofibrate.

Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ATT2, by enabling the fine-tuning of gibberellins, is expected to be a potential new post-Green Revolution gene.

The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

Tumor-derived extracellular vesicles (EVs) critically regulate tumor development and progression. Here the authors show that, in a mouse model of breast cancer, miR-9-5p-loaded EVs promote cholesterol biosynthesis and conversion into the oncometabolite 25-hydroxycholesterol, favoring immune evasion and promoting liver metastasis.

The lack of microenvironment understanding results in unsatisfactory conductivity of solid polymer electrolytes. Here, authors report a data-driven exploration of weak coordination manipulation by plasticizer design for safe and energy-dense batteries.

A mechanism is uncovered that results in fetal hepatocytes having a paracrine role in providing genome protection to haematopoietic stem and progenitor cells.

Vertical transistors based on 2D semiconductors have the potential to reduce the footprint of electronic circuits, but their high-density integration remains challenging. Here, the authors report a vertical lamination approach for realizing high-density MoS₂ vertical sidewall transistors.

Ketone α-alkylation at the more hindered site is challenging. Here, the authors report a highly regioselective nickel-catalysed allylic alkylation of unsymmetrical ketones at the more-hindered α-site with allylic alcohols.