Search

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

The hetero-Diels–Alder reaction is a powerful strategy for constructing six-membered heterocycles, yet natural enzymatic hetero-Diels–Alder reactions are limited to a single heteroatom. Now a bifunctional enzyme, Abx₍₋₎F, is found to catalyse the dehydration and a dual-oxa Diels–Alder reaction to form the oxygen-bridged tricyclic acetal of (−)-anthrabenzoxocinones.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

Membranes supporting selective ion transport provide the opportunity to generate electricity from water sources with different salt concentrations. Now researchers report a strategy to align nanochannels in covalent organic framework membranes for unprecedented performance in osmotic energy harvesting.

Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonization and outgrowth of medulloblastoma cells in the leptomeninges.

The treatment of poorly differentiated thyroid cancer and anaplastic thyroid cancer remains challenging. Here, the authors perform multi-omic analysis of thyroid samples and identify proteomic clusters associated with distinct tumour microenvironment features.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Here, the authors identify SPIN1 as a member of the subcortical maternal complex (SCMC). The SCMC component FILIA protects H3K4me3 reprogramming and zygotic genome initiation by preventing nuclear entry of SPIN1.

Programmed cell death is a crucial process in biology and medicine. Here, authors identify that calcium overload enhances TLK2 activity, causing nuclear envelope rupture and neuronal death via a complex with LC8 and myosin IIA.

An interfacial catalytic polymerization strategy is able to turn nature-derived compounds into high-quality membranes for reverse osmosis, challenging traditional approaches for membrane production that use toxic amine-based monomers.

Double-stranded RNA (dsRNA) is key in immunity and cellular regulation. Here, using the PISA workflow, the authors find 218 proteins with altered solubility upon dsRNA binding. ZNF385A knockout activates interferon-β transcription and increases endogenous dsRNA levels, enhancing the bioactivity of 5-Aza-2’-deoxycytidine and NK cell-mediated cytotoxicity.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

Multi-omic analysis of the adult human prostate identifies spatially resolved cell populations with potential links to prostate carcinogenesis.

In this randomized controlled trial, the authors investigate the benefits of over-the-counter hearing aids on depression symptoms in older adults with mild–moderate hearing loss.

Phylogenetic origin of the Y haplome present in allopolyploid Triticeae species is unclear. Here, the authors report the genome assembly of allohexaploid Elymus nutans, reveal the all likely combinations of St, Y, and H haplomes during the allopolyploid origins, and identify gene responsible for UV-B radiation adaptation.

The patterning of perovskites faces stringent and complex fabrication processes. Here, authors realize erasable patterns based on mix-halide perovskite films via a direct photo-patterning technique, yielding multi-level pattern encoding technology.

Hyperbolic shear polaritons (HShPs) are strongly confined light-matter excitations that have been previously observed in low-symmetry 3D materials with limited tunability. Here, the authors report the observation and manipulation of HShPs in twisted bilayers α-MoO₃ by tuning the sample structure or using a graphene electrostatic gate.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Integrating remote sensing and eco-evolutionary theory, this study explains 80–84% of photosynthetic efficiency variation across ecosystems by incorporating plant traits such as chlorophyll and leaf longevity with climate data, highlighting the importance of these traits for global carbon modelling.

This study identifies a new chromatin state, transcription resistive, which is different from activation and silencing. This novel state is marked by H3K36me and needs interplay between SDG8 and other H3K36me methyltransferases.

Jiang et al. propose a kirigami-based, mechanically reconfigurable metasurface that utilizes simple uniform stretching to achieve unexpected and dynamic beam steering functions. This unique approach modifies the geometric phase and lattice constant synchronously based on the rotation of anisotropic meta-atoms, exhibiting extended degree of freedom and wave-tuning ranges.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

The realization of efficient perovskite/organic tandem solar cells has been challenging due to large voltage deficits and severe non-radiative recombination. Here, the authors introduce sandwiched hole transport configuration for more balanced carrier transport, achieving efficiency of 26.05%.

Phenotypic and genomic analyses of 215 Rosa accessions reveal the genomic foundations of phylogeny, domestication and evolutionary history of Rosa, providing insights and resources for harnessing wild germplasm in modern rose breeding.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

The immune regulatory mechanism for metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Here, the authors identify a c-kit⁺ cDC1 subset, which can be depleted by Desulfovibrio_sp.-induced H₂S via autophagic cell death and contributing to uncontrolled inflammation for MASH progression.

Studying nature to reveal the mechanisms of special wetting phenomena in biological systems can effectively inspire the design and fabrication of functional interfacial materials with superwettability. In this Review, the historical development, new phenomena and emerging applications of superwettability systems are discussed.

Jiang et al. identify Pax as a key regulator of Drosophila midgut homeostasis. Pax coordinates the Hippo and Notch pathways to control the proliferation and differentiation of intestinal stem cells (ISCs), ensuring homeostasis of midgut.

Small modular reactors are compact nuclear reactors that can be combined to create large-scale power plants. Here, authors demonstrate the practical feasibility of a multi-modular design in the HTR-PM nuclear plant, showing effective coordinated control of multiple reactor modules driving a common steam turbine for power generation.

Artificial nanochannels suffer from weak gating effects owing to their large nanopores failing to completely block ion transport in the off-states. Here, the authors present hydrogen bonded organic framework membranes with proton gating controlled by ambient humidity, using proton transport pathway switch instead of traditional ion blockage or activation effects.

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather pathological information for timely interventions. Here, the authors introduce a biodegradable and restorative neural interface for wireless real-time tracking.

As a ‘safe’ alternative to harmful monomeric halogenated flame retardants, the use of polymeric flame retardants has surged in recent years. The authors show that polymeric flame retardants break down in the environment into small toxic molecules that can pose environmental hazards.

Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.

Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

Little is known about nitrogen loss processes in deep-sea cold seeps. Here, the authors report that cold seeps are potential hotspots of nitrogen loss, revealing high rates and a diverse range of nitrogen loss genes across multiple microbial phyla.

Whole-genome sequencing coupled with whole-exome sequencing validation in Han Chinese patients reveals a diverse genetic basis for venous thromboembolism, and identifies GP6, TET2, and JAK2 as novel risk factors in East Asian populations.

Authors develop a siRNA delivery system, named Ionizable Polymeric Micelles (IPMs) which employs a FAPi modification, enabling IPMs to target activated hepatic stellate cells, silencing target genes and treating liver fibrosis.

This work shows a strategy to engineer the orientation of covalent organic framework membranes to an axis-aligned configuration that enables record performance for osmotic energy harvesting.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

Biomass valorization is a way to promote the ‘waste-to-wealth’ concept, which is a prerequisite condition for a future sustainable lifestyle. Here, the authors demonstrate a methodology to prepare chitin-derived supramolecular nanowires-stabilized single-atom site platinum catalysts.