Nature Search

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Jiangdong Huo
Audrey Le Bas
James H. Naismith
Amendments and Corrections15 Oct 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1094
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Jiandong Huo
Audrey Le Bas
James H. Naismith
Amendments and Corrections03 Feb 2021
Nature Structural & Molecular Biology

Volume: 28, P: 326
Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

Structures of pimeloyl-CoA synthetase (BioW) provide insights into its catalytic mechanism and how it selects the correct length of dicarboxylic acid substrate, guiding engineering to make the enzyme capable of producing alternative CoA products.

Menglu Wang
Lucile Moynié
Dominic J Campopiano
Research17 Apr 2017
Nature Chemical Biology

Volume: 13, P: 660-667
The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

Bacteria produce small iron-binding molecules called siderophores, which are recognised by outer-membrane transporters. Here, the authors show that a Pseudomonas transporter recognises the siderophore enterobactin using extracellular loops distant from the pore, and propose that there is a second binding site deeper inside the structure.

Lucile Moynié
Stefan Milenkovic
James H. Naismith
ResearchOpen Access14 Aug 2019
Nature Communications

Volume: 10, P: 1-14
Author Correction: Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Lachlan P. Deimel
Lucile Moynié
Quentin J. Sattentau
Amendments and CorrectionsOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-2
Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Penicillin and other β-lactam drugs form protein adducts that can facilitate allergic and other drug-directed responses. Here, Deimel et al. describe the pharmacokinetic, immunologic and structural determinants of anti-penicillin antibodies.

Lachlan P. Deimel
Lucile Moynié
Quentin J. Sattentau
ResearchOpen Access10 Aug 2024
Nature Communications

Volume: 15, P: 1-12
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spike protein and show that an engineered homotrimeric Nb prevents disease progression in a Syrian hamster model of COVID-19 when administered intranasally.

Jiandong Huo
Halina Mikolajek
Raymond J. Owens
ResearchOpen Access22 Sept 2021
Nature Communications

Volume: 12, P: 1-18
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Two nanobodies that bind SARS-CoV-2 spike RBD are shown to block interaction with receptor ACE2 and thus neutralize the virus, and have an additive effect with antibody CR3022.

Jiandong Huo
Audrey Le Bas
James H. Naismith
Research13 Jul 2020
Nature Structural & Molecular Biology

Volume: 27, P: 846-854
Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

In the outer membrane, trimeric porins control the cellular uptake of small molecules, including nutrients and antibacterial agents. In this Review, Pagès and colleagues discuss advances in our understanding of the roles of general porins in small-molecule translocation in Enterobacteriaceae and consider the crucial contribution of porins in antibiotic resistance.

Julia Vergalli
Igor V. Bodrenko
Jean-Marie Pagès
Reviews02 Dec 2019
Nature Reviews Microbiology

Volume: 18, P: 164-176

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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters

The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

Author Correction: Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

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