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Genomic landscape of multiple myeloma and its precursor conditions

The genomic features of precursor conditions of multiple myeloma provide multiple biological insights into disease origins and evolution, together with opportunities to identify those at highest risk of progression.

Jean-Baptiste Alberge
Ankit K. Dutta
Irene M. Ghobrial
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1493-1503
SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors

Lightbody et al. present SWIFT-seq, a single-cell RNA sequencing approach to profile circulating tumor cells from patients with multiple myeloma and its precursor conditions and leverage it to derive clinical and biological insights into the disease.

Elizabeth D. Lightbody
Romanos Sklavenitis-Pistofidis
Irene M. Ghobrial
Research08 Aug 2025
Nature Cancer

Volume: 6, P: 1595-1611
Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

The impact of tumor intrinsic and immune alterations on disease progression in patients with Waldenstrom’s Macroglobulinemia (WM) remains to be characterized. Here, the authors perform single-cell RNA-sequencing and identify distinct tumor subtypes, tumour microenvironment features and potential therapeutic vulnerabilities in patients with WM.

Romanos Sklavenitis-Pistofidis
Yoshinobu Konishi
Irene M. Ghobrial
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-19

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Genomic landscape of multiple myeloma and its precursor conditions

SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors

Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

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