Nature Search

An essential contractile ring protein controls cell division in Plasmodium falciparum

Schizogony is essential for blood stage infection of Plasmodium parasites and produces several daughter cells. Here, Rudlaff et al. identify PfCINCH and interacting proteins as essential components of the basal complex required to establish daughter cell boundaries.

Rachel M. Rudlaff
Stephan Kraemer
Jeffrey D. Dvorin
ResearchOpen Access16 May 2019
Nature Communications

Volume: 10, P: 1-13
Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Markus Ganter
Jonathan M. Goldberg
Manoj T. Duraisingh
Amendments and Corrections06 Mar 2017
Nature Microbiology

Volume: 2, P: 1
A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum

The authors discover a pseudophosphatase that is an essential component of the basal complex, a contractile ring required for cell division of the malaria parasite. Using a combination of genetics, biochemistry, and cell biology techniques, they demonstrate that the pseudophosphatase, PfPPP8, is critical for integrity and contraction of the basal complex.

Alexander A. Morano
Rachel M. Rudlaff
Jeffrey D. Dvorin
ResearchOpen Access03 Jul 2023
Nature Communications

Volume: 14, P: 1-17
An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites

Blood-stage malaria parasites replicate through a specialised type of cell division known as schizogony. Here, Absalon et al. identify a parasite protein that is essential during schizogony for cytokinesis and formation of the inner membrane complex, the structural scaffold of daughter parasites.

Sabrina Absalon
Jonathan A. Robbins
Jeffrey D. Dvorin
ResearchOpen Access28 Apr 2016
Nature Communications

Volume: 7, P: 1-11
CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection

A genome-wide CRISPR-based screen of Toxoplasma gondii during mouse infection reveals previously uncharacterized factors contributing to parasite virulence.

Christopher J. Giuliano
Kenneth J. Wei
Sebastian Lourido
Research08 Jul 2024
Nature Microbiology

Volume: 9, P: 2323-2343
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

Junqueira et al. show that human γδ T cells control erythrocytic Plasmodium falciparum infection by multiple mechanisms: antibody-dependent phagocytosis, cytotoxic-granule-mediated erythrocyte lysis and direct parasite killing.

Caroline Junqueira
Rafael B. Polidoro
Judy Lieberman
Research11 Jan 2021
Nature Immunology

Volume: 22, P: 347-357
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

Antibodies against Plasmodium falciparum glutamic-acid-rich protein (PfGARP), an antigen expressed on the surface of infected red blood cells, kill P. falciparum parasites by inducing programmed cell death and reduce the risk of severe malaria.

Dipak K. Raj
Alok Das Mohapatra
Jonathan D. Kurtis
Research22 Apr 2020
Nature

Volume: 582, P: 104-108
PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages

Functional characterization of PfFBXO1, utilizing cell biology, genetics, and biochemistry, demonstrates essential roles for this protein in formation of the inner membrane complex in asexual merozoites and sexual-stage gametocytes.

Sreelakshmi K. Sreenivasamurthy
Carlos Gustavo Baptista
Jeffrey D. Dvorin
ResearchOpen Access07 Feb 2025
Communications Biology

Volume: 8, P: 1-19
PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.

Sudhir Kumar
Manish Kumar
Pushkar Sharma
ResearchOpen Access05 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Plasmodium falciparum kinase PfCRK4 is a key regulator of DNA replication in schizonts, required both during the intraerythrocytic blood stage of malaria infection and for transmission.

Markus Ganter
Jonathan M. Goldberg
Manoj T. Duraisingh
Research17 Feb 2017
Nature Microbiology

Volume: 2, P: 1-9

Search

An essential contractile ring protein controls cell division in Plasmodium falciparum

Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum

An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites

CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection

γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

Search

Quick links

Search

Filter By:

Search

Quick links