Nature Search

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

The m6A reader IGF2BP3 is upregulated in various cancer, including glioblastoma. Here the authors report that IGF2BP3 facilitates NETosis and glioma survival as well as resistance to oncolytic herpes simplex virotherapy.

Weiwei Dai
Ruotong Tian
Minfeng Shu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma

Zhonggang Shi
Jianyi Zhao
Yingying Lin
ResearchOpen Access26 Aug 2025
Bone Research

Volume: 13, P: 1-13
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.

Yuanpei Li
Xiaoniu He
Han You
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-23
Clinical and biomarker analyses of sintilimab versus chemotherapy as second-line therapy for advanced or metastatic esophageal squamous cell carcinoma: a randomized, open-label phase 2 study (ORIENT-2)

Patients with advanced esophageal cancer have poor prognosis and limited treatment options. This randomized, phase II trial compares the efficacy and safety of the anti-PD-1 antibody sintilimab versus chemotherapy in Chinese patients with esophageal squamous cell carcinoma after first-line therapy

Jianming Xu
Yi Li
Christoph Mancao
ResearchOpen Access14 Feb 2022
Nature Communications

Volume: 13, P: 1-12
Anchored multiplex PCR for targeted next-generation sequencing

Scalable and rapid target enrichment method for next-generation sequencing of clinical-grade, formalin-fixed paraffin-embedded cancer samples.

Zongli Zheng
Matthew Liebers
Long Phi Le
Research10 Nov 2014
Nature Medicine

Volume: 20, P: 1479-1484
Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain

Juxiang Chen
Yan Huang
Yi Xie
Research25 Apr 2003
Journal of Human Genetics

Volume: 48, P: 217-221
Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial

Jiujie Cui
Shukui Qin
Liwei Wang
ResearchOpen Access19 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

Ting Tian
Yu Zhou
Hesheng Luo
ResearchOpen Access01 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
SPP1 promoter polymorphisms and glioma risk in a Chinese Han population

Juxiang Chen
Qihan Wu
Daru Lu
Research27 May 2010
Journal of Human Genetics

Volume: 55, P: 456-461

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Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions

Clinical and biomarker analyses of sintilimab versus chemotherapy as second-line therapy for advanced or metastatic esophageal squamous cell carcinoma: a randomized, open-label phase 2 study (ORIENT-2)

Anchored multiplex PCR for targeted next-generation sequencing

Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain

Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

SPP1 promoter polymorphisms and glioma risk in a Chinese Han population

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