Nature Search

Real-time dynamic polygenic prediction for streaming data

Real-time PRS-CS (rtPRS-CS) is a polygenic prediction method that can incorporate streaming data for updating single-nucleotide polymorphism weights in real time, thereby maximizing the prediction accuracy of polygenic risk scores over time across various traits.

Justin D. Tubbs
Yu Chen
Tian Ge
Research29 Oct 2025
Nature Genetics

P: 1-9
Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort

Henri M. Garrison-Desany
Cecilia A. Hinojosa
Christy A. Denckla
ResearchOpen Access24 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-12
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans

The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.

Laura K. Case
Jaquette Liljencrantz
Alexander T. Chesler
ResearchOpen Access28 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data

Mendelian randomization methods are prone to produce false positive results when assumptions are violated. Here, the authors propose a statistical model that offers good power to detect causation between traits while controlling the false positive rate.

Zipeng Liu
Yiming Qin
Pak Chung Sham
ResearchOpen Access28 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis

Tracy L. Warren
Justin D. Tubbs
Alex S. Nord
ResearchOpen Access15 Mar 2024
Molecular Psychiatry

Volume: 29, P: 2389-2398
Permeability scaling relationships of volcanic tuff from core to field scale measurements

Dolan D. Lucero
S. Michelle Bourret
Cleat Zeiler
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Correction: Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population

Mingrui Li
Yanli Li
Yin Yao
Amendments and Corrections04 Jan 2021
Molecular Psychiatry

Volume: 26, P: 4486
Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population

Mingrui Li
Yanli Li
Yin Yao
Research05 Dec 2020
Molecular Psychiatry

Volume: 26, P: 4475-4485
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction

Fanglin Guan
Tong Ni
Hongsheng Gui
Reviews30 Jun 2021
Molecular Psychiatry

Volume: 27, P: 113-126

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