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Showing 1–8 of 8 results
Advanced filters: Author: Junting Ai Clear advanced filters

  • This study reports a donor DNA-free approach for gene knock-up based on CRISPR. It induced designed promoter swap or replacement for target genes by triggering genomic inversion or duplication so as to elevate gene expression and generate new traits.

    • Yu Lu
    • Jiyao Wang
    • Linjian Jiang
    Research
    Nature Plants
    Volume: 7, P: 1445-1452

  • Pre-B cells undergo a transition checkpoint needed for developmental progression. Mandal and colleagues show that the CXCL12–CXCR4 signaling axis orchestrates late B cell lymphopoiesis by suppressing Myc and cyclin D genes and promoting Rag-mediated recombination of immunoglobulin light-chain genes.

    • Malay Mandal
    • Michael K. Okoreeh
    • Marcus R. Clark
    Research
    Nature Immunology
    Volume: 20, P: 1393-1403

  • Savage and colleagues identify a population of CD4+ T cells within the endogenous repertoire that exhibit hallmarks of overt self-reactivity, spontaneously adopt a follicular helper T cell phenotype and are enriched in non-lymphoid organs following sustained Treg cell depletion.

    • Victoria Lee
    • Donald M. Rodriguez
    • Peter A. Savage
    Research
    Nature Immunology
    Volume: 24, P: 487-500

  • Germinal centers are typically divided into dark and light zones. Clark and colleagues identify ‘gray zone’ cyclin B1+ B cell clusters as sites of ongoing cell proliferation, and these cells are distinct from dark zone B cells that undergo AID-dependent somatic hypermutation. This separation of function safeguards B cells undergoing DNA replication against potential mutagenic events that could result in neoplastic transformation.

    • Domenick E. Kennedy
    • Michael K. Okoreeh
    • Marcus R. Clark
    Research
    Nature Immunology
    Volume: 21, P: 660-670

  • It remains difficult to distinguish cognate APC–T cell interactions in human tissue sections. Clark and colleagues have developed an imaging–machine-learning pipeline that uses deep convolutional and tuned neural networks to identify the combination of distance and cell-shape features that can discriminate between bystander human APC–T cell interactions and cognate interactions in situ.

    • Vladimir M. Liarski
    • Adam Sibley
    • Marcus R. Clark
    Research
    Nature Immunology
    Volume: 20, P: 503-513

  • The COVID-19 pandemic has highlighted the importance of materials and coatings for antiviral surfaces. Here, a comprehensive review is performed for natural and synthetic antiviral and virucidal materials, including a discussion of their underpinning mechanisms.

    • Paulina D. Rakowska
    • Mariavitalia Tiddia
    • Ian S. Gilmore
    ReviewsOpen Access
    Communications Materials
    Volume: 2, P: 1-19