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Scientific Reports (16)
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Showing 1–50 of 59 results

Advanced filters: Author: Huiyuan Zhang Clear advanced filters

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Kimitoshi Kimura
Ayshwarya Subramanian
Vijay K. Kuchroo
Research09 Apr 2025
Nature

P: 1-14
Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

The protective role of MAIT cells in the HFRS disease and the ER stress related mechanisms behind MAIT cell pyroptosis during HTNV infection.

Yusi Zhang
He Liu
Yun Zhang
ResearchOpen Access01 Apr 2025
Communications Biology

Volume: 8, P: 1-13
LLM-based intelligent Q&A system for railway locomotive maintenance standardization

Ao Chen
Ye Tian
Huiyuan Zhang
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-21
Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States

Post-acute sequelae of SARS-CoV-2 infection (PASC) have been shown to vary by race/ethnicity, but evidence is limited for children and adolescents. Here, the authors investigate variations in PASC by race/ethnicity in those aged under 21 years using electronic health record data from the United States.

Dazheng Zhang
Bingyu Zhang
Yong Chen
ResearchOpen Access21 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

Several studies have shown that Fusobacterium nucleatum aggravates colorectal cancer (CRC) development and chemoresistance. Here the authors show that F. nucleatum is enriched preferentially in patients with KRAS p.G12D mutant CRC and that it promotes colorectal tumorigenesis in preclinical models by binding DHX15 on tumor cells.

Huiyuan Zhu
Man Li
Huanlong Qin
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-15
TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells

Zhenyu Wang
Huiyuan Zhang
Hong Zhang
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
En route to a circular nitrogen economy

Recovering ammonia from industrial wastewater via nitrate-to-ammonia reduction for a more sustainable nitrogen cycle faces challenges due to complex wastewater matrices and suboptimal reactor design. Now, research presents a membrane-free electrolysis system that enables efficient and stable ammonia recovery from actual wastewater.

Lei Shi
Huiyuan Zhu
News & Views28 Aug 2024
Nature Sustainability

Volume: 7, P: 1221-1222
Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China

Initial results of serological surveillance in China provide valuable data for estimation of the cumulative prevalence of SARS-CoV-2 infection in the general population.

Xin Xu
Jian Sun
Fan Fan Hou
Research05 Jun 2020
Nature Medicine

Volume: 26, P: 1193-1195
Author Correction: Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China

Xin Xu
Jian Sun
Fan Fan Hou
Amendments and Corrections18 Aug 2020
Nature Medicine

Volume: 26, P: 1494
Cutaneous wound healing functions of novel milk-derived antimicrobial peptides, hLFT-68 and hLFT-309 from human lactotransferrin, and bLGB-111 from bovine β-lactoglobulin

Xixian Li
Wanning Zhang
Yan Jin
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Mesenchymal stem cells (MSC) are used for immunosuppressive therapy and a uniform source or heterogeneity characterisation is needed. Here the authors use multi-omics to compare human MSC from different sources and ages of donors and show differences in gene expression and immunosuppressive function.

Yuchen Gao
Ying Chi
Xiaomin Zhang
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Publisher Correction: Synthesis of core/shell nanocrystals with ordered intermetallic single-atom alloy layers for nitrate electroreduction to ammonia

Qiang Gao
Bingqing Yao
Huiyuan Zhu
Amendments and Corrections22 Mar 2023
Nature Synthesis

Volume: 2, P: 458
A network analysis of the heterogeneity and associated risk and protective factors of depression and anxiety among college students

Chunjuan Niu
Yaye Jiang
Yan Peng
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
A coordinate-to-semantic attention network for multi-label ancient Chinese architecture image classification

Sulan Zhang
Fei Wang
Jianghui Cai
ResearchOpen Access15 Feb 2025
npj Heritage Science

Volume: 13, P: 1-13
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.

Sibo Zhao
Jia Li
Xiao-Nan Li
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Volcanic fertilization of Late Triassic lacustrine algal blooms

In Late Triassic lake ecosystems, volcanic ash deposition boosted primary productivity, enhanced organic carbon sequestration, and triggered water-column anoxia, reshaping carbon cycling dynamics, according to geochemical, micropaleontological and sedimentological data from the Yanchang Formation, North China.

Quanyou Liu
Qian Pang
Thomas J. Algeo
ResearchOpen Access13 Mar 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Harnessing strong metal–support interactions via a reverse route

Strong metal–support interactions (SMSI) are effective in tuning the structures and catalytic performances of catalysts but limited by the poor exposure of active sites. Here, the authors develop a strategy to engineer SMSI via a reverse route, which is in favor of metal site exposure while embracing the SMSI.

Peiwen Wu
Shuai Tan
Huiyuan Zhu
ResearchOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1-10
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

The transcription factor STAT3 regulates production of inflammatory cytokines by modulating NF-κB signalling. Here the authors show that STAT3 is a transcriptional repressor of the E2 ubiquitin-conjugating enzyme Ubc13, modulating NF-κB by regulating Ubc13 abundance.

Huiyuan Zhang
Hongbo Hu
Stephanie S. Watowich
Research15 Dec 2014
Nature Communications

Volume: 5, P: 1-10
Synthesis of core/shell nanocrystals with ordered intermetallic single-atom alloy layers for nitrate electroreduction to ammonia

Well-defined single-atom alloy (SAA) nanocrystals possess isolated atom centres and tunable electronic properties but are challenging to synthesize. Here, a direct solution-phase synthesis of Cu/CuAu core/shell nanocubes with tunable SAA layers is reported. The Cu/CuAu nanomaterial is highly active for the electrocatalytic conversion of nitrate into ammonia.

Qiang Gao
Bingqing Yao
Huiyuan Zhu
Research09 Mar 2023
Nature Synthesis

Volume: 2, P: 624-634
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas

Sibo Zhao
Jia Li
Xiao-Nan Li
Amendments and CorrectionsOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1
Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates

Using a multi-omics approach, Wang et al. explored sex-specific and region-specific patterns of intestinal aging in non-human primates, identifying regulators with conserved functions in Caenorhabditis elegans intestinal aging, in colitis in mice and in patient colorectal cancer samples.

Xinyuan Wang
Yaru Luo
Lunzhi Dai
ResearchOpen Access06 Feb 2024
Nature Aging

Volume: 4, P: 414-433
Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut

Xina Xiao
Meng Hu
Lunzhi Dai
ResearchOpen Access08 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

SOCS proteins suppress cytokine signaling by inhibiting activation of STAT signal transducers. Dong and colleagues show that the SOCS protein CIS is induced by IL-4 to control T_H2 and T_H9 helper T cell differentiation.

Xuexian O Yang
Huiyuan Zhang
Chen Dong
Research02 Jun 2013
Nature Immunology

Volume: 14, P: 732-740
MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3

Peripherally derived regulatory T cells (pT_reg) exhibit immunosuppressive capacity. Here, the authors show that microRNA-31 acting through inhibiting its direct target Gprc5a negatively regulates pT_reggeneration and promotes the development of experimental autoimmune encephalomyelitis.

Lingyun Zhang
Fang Ke
Honglin Wang
ResearchOpen Access13 Jul 2015
Nature Communications

Volume: 6, P: 1-12
The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68

Liang Zhao
Yang Zhao
Fazheng Ren
ResearchOpen Access07 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
The third form electric organ discharge of electric eels

Jun Xu
Xiang Cui
Huiyuan Zhang
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Breaking adsorption-energy scaling limitations of electrocatalytic nitrate reduction on intermetallic CuPd nanocubes by machine-learned insights

Machine learning is a powerful tool for screening electrocatalytic materials. Here, the authors reported a seamless integration of machine-learned physical insights with the controlled synthesis of structurally ordered intermetallic nanocrystals and well-defined catalytic sites for efficient nitrate reduction to ammonia.

Qiang Gao
Hemanth Somarajan Pillai
Huiyuan Zhu
ResearchOpen Access29 Apr 2022
Nature Communications

Volume: 13, P: 1-12
NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

Psoriasis is accompanied by NF-κB activation and hyperplasia. Here the authors show that NF-κB transcriptionally activates miR-31, which downregulates a negative cell cycle regulator protein phosphatase 6, and that this is critical for NF-κB to drive keratinocyte hyperproliferation.

Sha Yan
Zhenyao Xu
Honglin Wang
ResearchOpen Access03 Jul 2015
Nature Communications

Volume: 6, P: 1-15
Criteria for Applying the Lucas-Washburn Law

Kewen Li
Danfeng Zhang
Yanan Yang
ResearchOpen Access14 Sept 2015
Scientific Reports

Volume: 5, P: 1-7
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-mutant LUAD.

Mauricio S. Caetano
Maya Hassane
Seyed Javad Moghaddam
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-11
A dynamic nomogram for predict individual risk of malignant brain edema after endovascular thrombectomy in acute ischemic stroke

Huiyuan Wang
Chenghua Xu
Yu Geng
ResearchOpen Access25 Apr 2024
Scientific Reports

Volume: 14, P: 1-11
Childhood and adolescent essential thrombocythemia and prefibrotic primary myelofibrosis: insights into diagnosis, outcomes, and treatment from a large Chinese cohort

Rongfeng Fu
Huan Dong
Lei Zhang
Research08 Oct 2024
Leukemia

Volume: 39, P: 155-165
5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions

Qingyi Wang
Huiyuan Zhang
Yuchun Gu
ResearchOpen Access22 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation

Yuyang Rao
Wenting Liu
Jiabao Lin
ResearchOpen Access13 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
Fast inflows as the adjacent fuel of supermassive black hole accretion disks in quasars

Observations of highly redshifted broad absorption lines of helium and hydrogen atoms provide unambiguous evidence of fast infalling gas that is merging into an accretion disk around a black hole.

Hongyan Zhou
Xiheng Shi
Zhihao Zhong
Research04 Sept 2019
Nature

Volume: 573, P: 83-86
Induction and transcriptional regulation of the co-inhibitory gene module in T cells

A module of co-inhibitory T cell receptors, driven by the cytokine IL-27, is identified in mice that is regulated by the transcription factors PRDM1 and c-MAF.

Norio Chihara
Asaf Madi
Vijay K. Kuchroo
Research13 Jun 2018
Nature

Volume: 558, P: 454-459
CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas

Lin Qi
Yuchen Du
Xiao-Nan Li
Research04 Jun 2024
British Journal of Cancer

Volume: 131, P: 258-270
The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response

Zhiwen Gu
Xueying Chen
Hongbo Hu
ResearchOpen Access12 Nov 2020
Cellular & Molecular Immunology

Volume: 18, P: 1981-1994
Cytokines help suggest aplastic anemia with pulmonary bacterial or co-fungal infection

Jinping Zhang
Zefeng Yang
Zengzheng Li
ResearchOpen Access01 Nov 2022
Scientific Reports

Volume: 12, P: 1-8
Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

Mingyao Wang
Zhe Zhang
Chen Wang
ResearchOpen Access13 May 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

Yunfei Chen
Yanmei Xu
Lei Zhang
ResearchOpen Access23 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Vesicle miR-195 derived from Endothelial Cells Inhibits Expression of Serotonin Transporter in Vessel Smooth Muscle Cells

Junzhong Gu
Huiyuan Zhang
Yuchun Gu
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

Jinyuan Luoqian
Wenyong Yang
Peng Lei
Research08 Jun 2022
Cellular & Molecular Immunology

Volume: 19, P: 913-924
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis

Huiyuan Wang
Chenyi Zhong
Jie Wu
ResearchOpen Access30 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-11
Mast cells inhibit colorectal cancer development by inducing ER stress through secreting Cystatin C

Feifei Song
Youhua Zhang
Jiyu Li
Research19 Nov 2022
Oncogene

Volume: 42, P: 209-223
Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis

Zhenghu Chen
Long Wang
Jed G. Nuchtern
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis

Yongfeng Wang
Long Wang
Jianhua Yang
ResearchOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
The Adhesion of Lactobacillus salivarius REN to a Human Intestinal Epithelial Cell Line Requires S-layer Proteins

Ran Wang
Lun Jiang
Fazheng Ren
ResearchOpen Access10 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies

This study confirms the preservation of EZH2 overexpression in 22 patient-derived orthotopic xenograft models of pediatric brain tumors. The authors demonstrate the activity of an FDA-approved EZH2 inhibitor, tazemetostat, alone and in combination with radiation in a subset of the models, and identifies EZH2-negative cells as potential cause of therapy resistance.

Lin Qi
Holly Lindsay
Xiao-Nan Li
Research20 Nov 2021
Laboratory Investigation

Volume: 102, P: 185-193

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