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Showing 1–8 of 8 results
Advanced filters: Author: Hugoline G. de Haan Clear advanced filters

  • A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

    • Ji Chen
    • Cassandra N. Spracklen
    • Cornelia van Duijn
    Research
    Nature Genetics
    Volume: 53, P: 840-860

  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Melinda Mills, Nicola Barban, Harold Snieder, Marcel den Hoed and colleagues perform a meta-analysis of data from over 300,000 individuals for age at first birth and number of children ever born. They identify 12 significant loci that associate with these traits, providing insights into the genetic basis of human reproductive behavior.

    • Nicola Barban
    • Rick Jansen
    • Melinda C Mills
    Research
    Nature Genetics
    Volume: 48, P: 1462-1472

  • An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.

    • Peter K. Joshi
    • Tonu Esko
    • James F. Wilson
    Research
    Nature
    Volume: 523, P: 459-462

  • Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

    • Momoko Horikoshi
    • Robin N. Beaumont
    • Rachel M. Freathy
    Research
    Nature
    Volume: 538, P: 248-252

  • White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

    • Muralidharan Sargurupremraj
    • Hideaki Suzuki
    • Stéphanie Debette
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18